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Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME

Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME

Probe card assembly and kit, and methods of using same

A probe card assembly includes a probe card, a space transformer having resilient contact structures (probe elements) mounted directly thereto (i.e., without the need for additional connecting wires or the like) and extending from terminals on a surface thereof, and an interposer disposed between the space transformer and the probe card. The space transformer and interposer are "stacked up" so that the orientation of the space transformer, hence the orientation of the tips of the probe elements, can be adjusted without changing the orientation of the probe card. Suitable mechanisms for adjusting the orientation of the space transformer, and for determining what adjustments to make, are disclosed. The interposer has resilient contact structures extending from both the top and bottom surfaces thereof, and ensures that electrical connections are maintained between the space transformer and the probe card throughout the space transformer's range of adjustment, by virtue of the interposer's inherent compliance. Multiple die sites on a semiconductor wafer are readily probed using the disclosed techniques, and the probe elements can be arranged to optimize probing of an entire wafer. Composite interconnection elements having a relatively soft core overcoated by a relatively hard shell, as the resilient contact structures are described.
Owner:FORMFACTOR INC

Probe card assembly

In a probe card assembly, a series of probe elements can be arrayed on a silicon space transformer. The silicon space transformer can be fabricated with an array of primary contacts in a very tight pitch, comparable to the pitch of a semiconductor device. One preferred primary contact is a resilient spring contact. Conductive elements in the space transformer are routed to second contacts at a more relaxed pitch. In one preferred embodiment, the second contacts are suitable for directly attaching a ribbon cable, which in turn can be connected to provide selective connection to each primary contact. The silicon space transformer is mounted in a fixture that provides for resilient connection to a wafer or device to be tested. This fixture can be adjusted to planarize the primary contacts with the plane of a support probe card board.
Owner:FORMFACTOR INC

Methods of removably mounting electronic components to a circuit board, and sockets formed by the methods

Surface-mount, solder-down sockets are described which permit electronic components such as semiconductor packages to be releasably mounted to a circuit board. Generally, the socket includes resilient contact structures extending from a top surface of a support substrate, and solder-ball (or other suitable) contact structures disposed on a bottom surface of the support substrate. Composite interconnection elements are described for use as the resilient contact structures disposed atop the support substrate. In use, the support substrate is soldered down onto the circuit board, the contact structures on the bottom surface of the support substrate contacting corresponding contact areas on the circuit board. In any suitable manner, selected ones of the resilient contact structures atop the support substrate are connected, via the support substrate, to corresponding ones of the contact structures on the bottom surface of the support substrate.
Owner:FORMFACTOR INC

High Speed Bypass Cable Assembly

A cable bypass assembly is disclosed for use in providing a high speed transmission line for connecting a board mounted connector of an electronic device to a chip on the device board. The bypass cable assembly has a structure that permits it, where it is terminated to the board mounted connector and the chip member, or closely proximate thereto to replicate closely the geometry of the cable. The connector terminals are arranged in alignment with the cable signal conductors and shield extensions are provided so that shielding can be provided up to and over the termination between the cable signal conductors and the board connector terminal tails. Likewise, a similar termination structure is provided at the opposite end of the cable where a pair of terminals are supported by a second connector body and enclosed in a shield collar. The shield collar has an extension that engages the second end of the cable.
Owner:MOLEX INC

Operation ready transportable data center in a shipping container

A movable data center is disclosed that comprises a portable container in which an operable computer system is assembled. A data link, power supply link and cooling system are provided through ports on the exterior of the container. The computer system is assembled to a rack that is secured to the container with a shock absorbing mechanism.
Owner:ORACLE INT CORP

Fringe Field Switching Mode Liquid Crystal Display Device

Provided is a Fringe Field Switching (FFS) mode Liquid Crystal Display (LCD) In the FFS mode LCD, a lower substrate, an upper substrate and a liquid crystal layer interposed between the substrates are included, each pixel region is defined by gate lines and data lines formed to cross each other on the lower substrate, and switching devices are disposed at intersections of the gate lines and the data lines. The FFS mode LCD includes a transparent pixel electrode, and a transparent common electrode disposed apart from the transparent pixel electrode by an insulating layer interposed between the transparent pixel electrode and the transparent common electrode, in the pixel region to adjust transmittance by applying an electric field to the liquid crystal layer, the transparent common electrode has a plurality of bars having a predetermined width in a direction substantially parallel to the data lines, the transparent common electrode has a first bar formed to cover the data lines and a second bar formed adjacent to the first bar in a central area of the pixel region, a distance between the first bar and the second bar is larger than a distance between bars formed in the pixel region, and one end of the transparent pixel electrode is disposed between the first bar and the adjacent secondbar.
Owner:HYDIS TECH

Multi-component telepresence system and method

The present invention provides systems and methods for performing robotically-assisted surgical procedures on a patient. In particular, a three-component surgical system is provided that includes a non-sterile drive and control component, a sterilizable end effector or surgical tool and an intermediate connector component that includes mechanical elements for coupling the surgical tool with the drive and control component and for transferring motion and electrical signals therebetween. The drive and control component is shielded from the sterile surgical site, the surgical tool is sterilizable and disposable and the intermediate connector is sterilizable and reusable. In this manner, the intermediate connector can be sterilized after a surgical procedure without damaging the motors or electrical connections within the drive and control component of the robotic system.
Owner:INTUITIVE SURGICAL OPERATIONS INC

Method and apparatus for administering micro-ingredient feed additives to animal feed rations

A method and apparatus are provided for administering micro-ingredient feed additives to animal feed rations. The apparatus may be referred to as a system which includes a number of discrete components which cooperate together to ultimately deliver micro-ingredients to a desired location, such as a feed mixer containing a feed ration. Structure is provided for storing, measuring, dispensing, and pneumatically conveying the micro-ingredients. Measuring of the micro-ingredients may be achieved by loss in weight, gain in weight, or volumetric metering methods. Pneumatic transport may be achieved either by a single transport line, or a plurality of transport lines. The system is operated by a control unit which controls components of the system to achieve delivery of specified amounts and types of micro-ingredients to the feed ration.
Owner:ANIMAL HEALTH INT

Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Owner:HALOZYME +6

Electric field proximity detector for floating and grounded targets

An electric field proximity detector capable of detecting partially conductive or conductive objects regardless of their impedance to circuit ground. The detector has a sensor with a transmitting electrode, a receiving electrode, and at least one circuit ground electrode preferably arranged in a bulls-eye configuration with the ground electrode between the transmitter and receiver electrodes. With appropriate sizing, upon the approach of an object, a signal received by the receiving electrode decreases, at least until the object is within a threshold distance of the sensor. The size and positioning of the ground electrode further reduces the effects of stray capacitance.
Owner:APPLE INC

Needle tip guard for percutaneous entry needles

A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.
Owner:B BRAUN MELSUNGEN AG

Needle tip guard for percutaneous entry needles

A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.
Owner:B BRAUN MELSUNGEN AG

Probe card assembly and kit, and methods of making same

A probe card assembly includes a probe card, a space transformer having resilient contact structures (probe elements) mounted directly to (i.e., without the need for additional connecting wires or the like) and extending from terminals on a surface thereof, and an interposer disposed between the space transformer and the probe card. The space transformer and interposer are “stacked up” so that the orientation of the space transformer, hence the orientation of the tips of the probe elements, can be adjusted without changing the orientation of the probe card. Suitable mechanisms for adjusting the orientation of the space transformer, and for determining what adjustments to make, are disclosed. The interposer has resilient contact structures extending from both the top and bottom surfaces thereof, and ensures that electrical connections are maintained between the space transformer and the probe card throughout the space transformer's range of adjustment, by virtue of the interposer's inherent compliance. Multiple die sites on a semiconductor wafer are readily probed using the disclosed techniques, and the probe elements can be arranged to optimize probing of an entire wafer. Composite interconnection elements having a relatively soft core overcoated by a relatively hard shell, as the resilient contact structures are described.
Owner:FORMFACTOR INC

Shielded planar capacitor

ActiveUS6903918B1Mitigate eddy current lossMinimize eddy current lossSemiconductor/solid-state device detailsFixed capacitor dielectricIsolation layerParasitic capacitance
A shielded planar capacitor structure (202) is discussed, formed within a Faraday cage (210) in an integrated circuit device (200). The capacitor structure (202) reduces parasitic capacitances within the integrated circuit device (200). The capacitor (202) comprises a capacitor stack (102) formed between a first and second metal layers (230,232) of the integrated circuit. The capacitor stack (102) has a first conductive layer formed from a third metal layer (106) disposed between the first and second metal layers (230,232) of the integrated circuit, a dielectric isolation layer (110) disposed upon the first conductive layer (106); and a second conductive layer (112) disposed upon the dielectric isolation layer (110) and overlying the first conductive layer (106). The structure (202) further has a first and second isolation layers (104,114) disposed upon opposite sides of the capacitor stack (102). The Faraday cage (210) is formed between the first and second metal layers (230,232) of the integrated circuit (200), comprising a first and second shield layers (402,414) each having a plurality of mutually electrically conductive spaced apart traces (404). The first and second isolation layers (404,414) and the capacitor stack (102,434) are sandwiched between the first and second shield layers (402,414). Conductive elements (432) are distributed around the periphery of the capacitor stack (102,434) and the first and second isolation layers (404,412). The conductive traces (424) of the first shield layer (402) are connected to the conductive traces (424) of the second shield layer (414) through the conductive elements (432).
Owner:TEXAS INSTR INC

Mobile phone capable of reducing an electromagnetic specific absorption rate in human bodies

A mobile phone capable of reducing an electromagnetic SAR in human bodies includes a base and a cover disposed on the base. The base includes an antenna for transmitting and receiving electromagnetic waves. The cover includes a screen and buttons. Electromagnetic absorbing materials having electric or magnetic loss are applied on the cover to mitigate electromagnetic waves radiating from the antenna into the user. Moreover, a meandered planar inverted-F antenna is attached to the back of the circuit board near the bottom of the base, which can generate a lower near field at the user's side than those in other directions, thereby reducing the electromagnetic specific absorption rate of the mobile phone in human bodies.
Owner:NAT TAIWAN UNIV OF SCI & TECH

Displacement sensor

ActiveUS20110316562A1Improve signal reliabilityTransducer be relatively robustResistance/reactance/impedenceMedical devicesWrong drugDrug delivery
A linear capacitance displacement transducer (1) comprising first (2) and second (3) fixed capacitor plate and a dielectric structure (5) moveable longitudinally within a space (4) between the first (2) and second (3) capacitor plates, the dielectric structure (5) being operatively coupled to a moveable element (8). The capacitor plates and the dielectric material may be cylindrical and disposed coaxially and concentrically. The transducer (1) enables a displacement sensor that is capable of monitoring liquid levels in a syringe type drug reservoir (101) with sufficient sensitivity as to allow detection of erroneous drug delivery. The sensor is inexpensive to manufacture and provides reliable performance through robust design.
Owner:INSULET NETHERLANDS BV

Touch screen input apparatus

A touch screen input apparatus includes a first electrode layer, a second electrode layer, and a controller. The first electrode layer is configured to perform sensing in a first direction, and provided with first electrode patterns which are formed on the top surface of a substrate. The second electrode layer is configured to perform sensing in a second direction, provided under the first electrode layer, and provided with second electrode patterns which are formed on the top surface of a substrate such that the second electrode patterns overlap the first electrode patterns through a surface on which the first electrode patterns are not formed, and which are spaced apart from each other by predetermined intervals. The control unit is configured to control the electrode patterns other than electrodes which are used to measure capacitance in a ground state.
Owner:POINTCHIPS CO LTD

Needle device

The present invention is directed to a shieldable blood collection set and a needle assembly for use therewith. The needle assembly includes a needle cannula having a puncture tip at a distal end, a hub which supports the needle cannula, and a shield. The hub and the shield are axially movable with respect to each other between a first sampling position, where the puncture tip is exposed from the shield, and a second shielded position where the shield covers the puncture tip. A gauze pad is connected to the shield through a tether. After a venipuncture procedure, the gauze is maintained over the needle puncture tip at the puncture site, and the needle is withdrawn from the patient by pulling on the hub. This movement causes the tether to tightly extend between the gauze and the shield, which causes the needle puncture tip to be withdrawn into the shield.
Owner:BECTON DICKINSON & CO

Memory cell architecture for reduced routing congestion

An improved memory cell architecture is provided herein for reducing, or altogether eliminating, chip-level routing congestion in System-on-Chip environments. Though only a few embodiments are provided herein, features common to the described embodiments include: the formation of bitlines in a lower-level metallization layer of the memory array, and the use of word lines and ground supply lines, both formed in inter-level metallization layer(s) of the memory array, for effective shielding of the bitlines against routing signals in the chip-level routing layer.
Owner:AVAGO TECH INT SALES PTE LTD

Novel infrared and radar integrated stealth fabric and preparation method thereof

The invention discloses a novel infrared and radar integrated stealth fabric and a preparation method thereof. The stealth fabric comprises an infrared camouflage surface layer and an antistatic bottom layer in turn from outside to inside; the infrared camouflage surface layer comprises an infrared stealth layer, a fabric layer and a radar wave absorption attenuation layer in turn from outside toinside; the infrared stealth layer is compounded by using a coating coated by an infrared stealth coating and a magnetron sputtering ITO (indium tin oxide) film arranged on the surface of the coating; the radar wave absorption attenuation layer comprises a sponge body; and a wave absorption material is adsorbed on the sponge body. The stealth fabric can realize radar stealth function and infraredstealth function at the same time, has good integral wave absorption effect and low surface density of materials, and has good effects on the aspects of breaking strength, bursting strength and the like. Moreover, excessive complex processes are not adopted for manufacturing the stealth fabric, and the stealth fabric can be produced by using a conventional fabric production method, so the stealthfabric is convenient for production and easy for implementation.
Owner:WUYI UNIV

Retractable boat top with arched canopy

A retractable boat top device is disclosed having an arched canopy assembly operatively deployed in mounted attachment upon a conventional radar arch or like elevated structure on the deck of a boat. The arched canopy assembly includes a stationery roof section formed having a curved planar surface transversely mounted within the radar arch, a pair of telescoping extension arms mounted on opposite sides of the roof section, and an arched roller assembled to hold a flexible canopy material thereon and operatively connected between the outer ends of the extension arms so that the flexible canopy material may be extended and retracted relative to the stationery roof section in an arched configuration substantially in the same plane as the roof section. The arched roller includes a curved roller bar supported coaxially within the bore of a flexible hose member that supports the canopy material in a rolled-up state and further includes torsion spring members mounted along opposite sides of the roller bar to maintain tension upon the canopy material during roll-out and retraction.
Owner:LIPPERT COMPONENTS MFG INC

Method of making a contact structure with a distinctly formed tip structure

A probe card assembly includes a probe card, a space transformer having resilient contact structures (probe elements) mounted directly to (i.e., without the need for additional connecting wires or the like) and extending from terminals on a surface thereof, and an interposer disposed between the space transformer and the probe card. The space transformer and interposer are “stacked up” so that the orientation of the space transformer, hence the orientation of the tips of the probe elements, can be adjusted without changing the orientation of the probe card. Suitable mechanisms for adjusting the orientation of the space transformer, and for determining what adjustments to make, are disclosed. The interposer has resilient contact structures extending from both the top and bottom surfaces thereof, and ensures that electrical connections are maintained between the space transformer and the probe card throughout the space transformer's range of adjustment, by virtue of the interposer's inherent compliance. Multiple die sites on a semiconductor wafer are readily probed using the disclosed techniques, and the probe elements can be arranged to optimize probing of an entire wafer. Composite interconnection elements having a relatively soft core overcoated by a relatively hard shell, as the resilient contact structures are described.
Owner:FORMFACTOR INC

Architecture for guiding the air flow in a disk storage device

A disk drive assembly enclosed in a housing, having a head disk assembly including a spindle, disks axially attached to the spindle, a driving motor for rotating the spindle, a read / write head, and a carriage assembly including a positioning arm, slider mechanism and a actuator / suspension mechanism. The slider mechanism is slidably attached to the positioning arm and the actuator suspension mechanism is attached to the positioning arm. The read / write head for reading or writing information to the disks is attached to the head positioning assembly at the slider mechanism. A fairing is attached to the positioning arm. The head positioning assembly is enclosed within the skimmer structure. The skimmer structure has a plurality of slots for receiving the disks of the disk pack. As the disks of the disk pack pass through the slots of the skimmer structure air is stripped away from the disks.
Owner:HITACHI GLOBAL STORAGE TECH NETHERLANDS BV

Three-wheeled vehicle with a fender assembly and lighting system therefor

A three-wheeled vehicle is designed for road use and has an internal combustion engine that drives a single rear wheel and a pair of steerable front wheels. The front wheels are partially covered by a fender assembly that includes a fender body and a fender support. The fender support moves in correspondence with the front wheels independent of the main frame. The fender also includes a lamp that is flush with the fender body.
Owner:BOMBARDIER RECREATIONAL PROD INC

Display panel having noise shielding structure

A circuit board area is formed on a front glass substrate of a liquid crystal display (LCD) panel, and driver ICs are mounted in the circuit board section. The driver ICs are electrically connected to an external display control device via a flexible printed circuit board (FPC). A metal foil is attached to one side of the FPC for shielding unnecessary radiating noises. The metal foil has connecting flap portions and the flap portions are fixed to an outer case of a backlight unit with a metal foil tape. The metal foil tape is also bonded to an external frame of an LCD device. As a result, the metal foil is electrically connected with the external frame and the radiating noises are effectively reduced.
Owner:DENSO CORP
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