Bionic peritoneum for open treatment and repair of abdominal cavity and preparation method thereof

Abstract

The invention relates to a bionic peritoneum for open treatment and repair of the abdominal cavity and a preparation method thereof, comprising hydrogel, polylactic acid-glycolic acid microspheres mounted on the hydrogel, and polylactic acid microspheres covered on the hydrogel and polylactic acid -Nanofibrous membrane on glycolic acid microspheres, by loading polylactic acid-glycolic acid microspheres on the hydrogel, the microspheres are the source of growth factors required for wound repair, and covered with a nanofiber membrane to form a double-layer membrane structure, constructing "artificial bionic peritoneum" applied to open wounds in the abdominal cavity; bionic peritoneum can not only protect the intestines, but also serve as a carrier for controlled-release microspheres, organically combine wound protection and drug release functions, and participate in wound repair; bionic peritoneum may be through the following mechanisms Promote healing, differentiate and participate in the formation of new tissue, or paracrine cytokines to promote the formation of new tissue; the synergistic effect of artificial peritoneum and microspheres, while directly participating in the regeneration of defective tissue, can mobilize the body's own regeneration and repair mechanism, and finally Realize rapid repair of open wounds in the abdominal cavity.

Description

technical field [0001] The invention relates to the technical field of open treatment and repair of the abdominal cavity, in particular to a bionic peritoneum for open treatment and repair of the abdominal cavity and a preparation method thereof. Background technique [0002] The repair of open wounds in the abdominal cavity is one of the important issues of wound repair. Trauma, infection and major abdominal surgery may lead to relative and absolute defects of the abdominal wall, which in turn may cause intestinal exposure and intestinal rupture, resulting in extremely high mortality and disability rates , Severe intra-abdominal infection is a common complication of abdominal trauma, gastrointestinal perforation, and severe pancreatitis. According to research at home and abroad, the treatment of abdominal infection is divided into the following stages: in the 1930s, surgical treatment reduced the mortality rate of patients with abdominal infection from 90% to about 50%; us...

AI Technical Summary

Problems solved by technology

In the early years, various patches were mainly used, such as polyester cloth, polypropylene mesh, absorbable mesh, decellularized human skin or pig skin, but the common feature of these patches is that the intestinal wall is gradually worn away, resulting in rupture of the intestinal tube

Although the addition of epidermal growth factor or the use of vacuum negative pressure suction technology can promote the growth of granulation tissue between intestinal tubes to a certain extent, it cannot restore normal intestinal microcirculatory blood flow, and eventually still leads to intestinal rupture and delayed wound healing.

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