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How to use betulinic acid

A technology of betulinic acid and betulinic acid is applied in the preparation field of diarrhea of ​​weaned piglets to achieve the effects of ensuring quality, improving villus height and relieving villus atrophy

Active Publication Date: 2016-12-07
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subsequent studies have found that betulinic acid has a variety of strong biological activities such as immune regulation, anti-oxidative stress, and anti-inflammation, while the application of betulinic acid in piglet diarrhea has rarely been reported.

Method used

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  • How to use betulinic acid
  • How to use betulinic acid
  • How to use betulinic acid

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] 30 healthy male KM mice, 4-5w, SPF grade, body weight (20±2) g, license number: (Xiang) 2009-0004, the feed is M02 mouse common breeding feed, mice and feed were purchased from Hunan Slack Jingda Laboratory Animal Company. The mice were placed in a breeding room at (22-25)°C and the relative humidity was 50% to 70%. After feeding for 1 week, they were randomly divided into 3 groups, namely the blank control group (group A), the cyclophosphamide group (group B), and the control group (group B). , intestinal mucosal injury model), betulinic acid and cyclophosphamide combined group (group C, betulinic acid was given at 0.5 mg / kgb w). Group C suspends betulinic acid in 1% soluble starch, and administers it by intragastric administration. Groups A and B are only administered 1% soluble starch, both given at 20ml / kg bw, 1 / d, For 14 consecutive days, the clinical manifestations and body weight changes were observed. One hour after the last administration, the mice in groups ...

example 2

[0057] In the feeding experiment, 90 weaned piglets at the age of 28 days and weighing (8.4±0.72) kg in the same nursery house were randomly divided into 3 experimental groups, and each experimental group had 3 repetitions. Group A is the blank control group (basic diet, without adding any drugs), group B is the betulinic acid group (basic diet+0.1% betulinic acid); group C is the antibiotic group (basic diet+50ppm oxytetracycline+50ppm aureomycin), the test period was 21d. One week before the test, the pig house was thoroughly cleaned and disinfected, and each group was dewormed once before the test, and the closed management mode was adopted to manage the pen. Concentrate feeding three times in the morning, middle and evening. It is advisable to have a small amount of feed left in the trough, and gradually increase it every day. Use automatic drinking fountains to drink water freely, clean up feces in time, and keep the pens well ventilated. Keep the ground dry and check f...

example 3

[0065] In the feeding experiment, 90 Du×Da×Chang triple cross weaned piglets at the age of 21 and weighing (5.73±0.41) kg in the same nursery house were selected and randomly divided into 3 experimental groups, with 3 repetitions in each experimental group. Group A is the blank control group (basic diet, without adding any drugs), group B is the betulinic acid group (basic diet+0.2% betulinic acid); group C is the antibiotic group (basic diet+50ppm oxytetracycline+50ppm aureomycin), the test period was 28 days. One week before the test, the pig house was thoroughly cleaned and disinfected, and each group was dewormed once before the test, and the closed management mode was adopted to manage the pen. Concentrate feeding three times in the morning, middle and evening. It is advisable to have a small amount of feed left in the trough, and gradually increase it every day. Use automatic drinking fountains to drink water freely, clean up feces in time, and keep the pens well ventil...

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Abstract

The invention belongs to the technical field of livestock breeding, and specifically discloses the use of betulinic acid in preparing preparations for preventing and treating diarrhea in livestock, especially weaned piglets. Adding betulinic acid to the feed of weaned piglets at a dose of 0.1-0.5% can significantly reduce the diarrhea rate of weaned piglets, improve the shape of the intestinal mucosa, protect the intestinal mucosal barrier, effectively improve the overall disease prevention and resistance of piglets, and increase daily weight gain.

Description

technical field [0001] The invention belongs to the technical field of livestock breeding, and in particular relates to the use of betulinic acid in preparing preparations for preventing and treating diarrhea in livestock, especially weaned piglets. Background technique [0002] In the current highly intensive farming, piglet diarrhea is a common and very harmful disease. The disease directly leads to a decline in the survival rate of piglets, slow growth, stagnation of development and becoming a dead pig, or even death, which affects the growth rate and feed conversion rate of the entire feeding period, and finally brings significant economic losses to the breeding industry. According to statistics, the death of piglets caused by diarrhea accounts for 39.8% of the total number of piglet deaths in my country every year. The average morbidity rate of piglet diarrhea is 46.5%, the mortality rate is 15%, and the direct economic loss caused is as high as 1 billion yuan. There ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K20/10A23K50/30A23K50/60
Inventor 易金娥邬静
Owner HUNAN AGRICULTURAL UNIV
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