Method for extracting magnolol from officinal magnolia barks

A magnolol and magnolol technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of small extraction amount, large energy consumption, expensive equipment, etc., and achieve high magnolol content, Avoid damage, facilitate the effect of treatment

Inactive Publication Date: 2014-12-24
GUILIN SANBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alkaline extraction and acid precipitation method is mainly used to extract magnolia bark by dipping method and immersion flow method, which has long extraction time and low extraction efficiency. "; adopt the ethanol reflux extraction method, although its extraction efficiency is high, it will consume a large amount of energy and increase the production cost, such as the application number is 200910069565.4, the name is "a method for changing the viscosity of magnolia bark extract"; supercritical CO 2 Magnolia officinalis extracted by extraction method has high extraction efficiency and good extraction purity, but the equipment is expensive and the extraction amount is small, so it is rarely used in actual production

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  • Method for extracting magnolol from officinal magnolia barks

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Effect test

Embodiment 1

[0020] A method for extracting magnolol from magnolia bark, specifically comprising the steps of:

[0021] 1) Raw material processing: 100kg Magnolia officinalis is pulverized;

[0022] 2) High-pressure micro-jet superfine pulverization treatment: Add 800 kg of pure water to the pulverized magnolia bark, process it with a high-speed shear emulsifier for 20 minutes at a speed of 10,000 r / min, and then use high-pressure micro-jet superfine pulverization equipment at 25°C for processing , the treatment pressure is 120MPa, the number of treatments is 2 times, and a paste liquid is obtained;

[0023] 3) Ultrasonic extraction: Add 0.01mol / L KOH solution equivalent to 40% by weight of the paste liquid to the paste liquid obtained in step 1), ultrasonically treat for 40min, the action temperature is 50°C, the power is 350W, and then use pure water Wash until the pH is neutral, filter to obtain Magnolia officinalis extract;

[0024] 4) Collect the extract obtained after ultrasonic ex...

Embodiment 2

[0027] A method for extracting magnolol from magnolia bark, specifically comprising the steps of:

[0028] 1) Raw material processing: magnolia bark pulverized;

[0029] 2) High-pressure micro-jet micro-grinding treatment: Add 1,000 kg of pure water to the crushed magnolia bark, process it with a high-speed shear emulsifier for 15 minutes at a speed of 8,000 r / min, and then use high-pressure micro-jet ultra-fine pulverization equipment to process at 25°C , the treatment pressure is 80MPa, and the number of treatments is 3 times to obtain a paste liquid;

[0030] 3) Ultrasonic extraction: Add 0.25mol / L NaOH solution equivalent to 30% weight of the paste liquid to the paste liquid obtained in step 1), ultrasonically treat it for 20min, the action temperature is 55°C, and the power is 200W, then use pure water Wash until the pH is neutral, filter to obtain Magnolia officinalis extract;

[0031] 4) Collect the extract obtained after ultrasonic extraction, add petroleum ether acc...

Embodiment 3

[0034] 1) Raw material processing: magnolia bark pulverized;

[0035] 2) High-pressure micro-jet micro-grinding treatment: Add 900 kg of pure water to the crushed magnolia bark, process it with a high-speed shear emulsifier for 10 minutes at a speed of 12000 r / min, and then use high-pressure micro-jet ultra-fine pulverization equipment to process at 25 ° C , the treatment pressure is 100MPa, and the number of treatments is 4 times to obtain a paste liquid;

[0036] 3) Ultrasonic extraction: Add 0.50 mol / L NaOH solution equivalent to 20% by weight of the paste liquid to the paste liquid obtained in step 1), ultrasonically treat for 30 minutes, the action temperature is 60 ° C, the power is 250 W, and then use pure water Wash until the pH is neutral, filter to obtain Magnolia officinalis extract;

[0037] 4) Collect the extract obtained after ultrasonic extraction, add petroleum ether according to the weight ratio of 1:3, heat to a slight boil, keep warm for 10min, heat filter,...

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Abstract

The invention discloses a method for extracting magnolol from officinal magnolia barks. The method comprises the following steps of raw material processing, high-pressure microjet superfine smashing processing, supersonic extraction, extraction, crystallization and drying to obtain the magnolol, and has the advantages of being high in content, high in extraction rate, simple in process, suitable for production, low in production cost and the like.

Description

technical field [0001] The invention relates to an extraction method in the field of biotechnology, in particular to a method for extracting magnolol from magnolia bark. Background technique [0002] Magnolia officinalis, also known as Zipu, Ziyoupu, Wenpu, etc. in the botanical range, is a plant of the Magnoliaceae and Magnolia genus, and the common species is Magnolia officinalis Rehd.et Wils. (Mognolia officinalis Rehd.et Wils.Var.biloba Rehd.et Wils.) Two kinds, mainly produced in Sichuan, Hubei and other places, Chinese medicinal materials specifically refer to the dry bark, root bark and branch bark of this plant. From April to June, the root bark and branch bark are stripped and dried directly in the shade. The dried bark is boiled in boiling water and then piled up in a damp place. When the inner surface is "sweaty" until the inner surface is purple-brown or brown, steam it until it is soft, take it out, and roll it into a tube. ,dry. Shredded, ginger is used. Its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/21C07C37/70
CPCC07C37/004
Inventor 卢照凯钟德品周晓青陆美珍梁小珍谢冬养
Owner GUILIN SANBAO PHARMA
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