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A kind of preparation method of chitosan/graphene oxide/hydroxyapatite/polyacrylamide composite material

A technology of hydroxyapatite and polyacrylamide, which is used in medical science, prosthesis and other directions, can solve the problems of lack of energy dissipation mechanism, low mechanical strength, low ductility, etc., to overcome poor mechanical properties and mechanical properties. The effect of enhancing and enhancing the mechanical properties of compression

Active Publication Date: 2015-12-30
星途(常州)碳材料有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general hydrogel lacks an effective energy dissipation mechanism due to the widely distributed long chains forming random cross-linking points through traditional covalent cross-linking, so it presents brittleness, low ductility, and low mechanical strength. Very limited, so it is necessary to further improve the mechanical properties of the gel material

Method used

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  • A kind of preparation method of chitosan/graphene oxide/hydroxyapatite/polyacrylamide composite material
  • A kind of preparation method of chitosan/graphene oxide/hydroxyapatite/polyacrylamide composite material
  • A kind of preparation method of chitosan/graphene oxide/hydroxyapatite/polyacrylamide composite material

Examples

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Embodiment 1

[0025] Example 1: Preparation method of chitosan / graphene oxide / hydroxyapatite / polyacrylamide composite material

[0026] (1) Prepare hydroxyapatite (HA) aqueous solution: Dissolve 0.1g of 12μm hydroxyapatite (HA) powder in 5mL of secondary water, and shake and stir to make it fully dissolved, that is, a concentration of 0.02g / mL is obtained Milky white HA solution;

[0027] (2) Preparation of chitosan (CS) aqueous solution: Dissolve 0.05g of chitosan (CS) powder in 5mL of secondary water, then add 0.2mL of acetic acid, and finally shake and stir to make it fully and quickly dissolved, that is, the concentration is 0.01 g / mL milky yellow CS solution;

[0028] (3) Preparation of graphene oxide (GO) aqueous solution: Dissolve 0.01g of graphene oxide (GO) powder in 5mL of secondary water, then shake and stir to make it fully and quickly dissolved, that is, a black and translucent GO with a concentration of 0.002g / mL is obtained Solution

[0029] (4) Preparation of cross-linking agent ...

Embodiment 2

[0043] Example 2: Preparation method of chitosan / graphene oxide / hydroxyapatite / polyacrylamide composite material

[0044] (1) Prepare hydroxyapatite (HA) aqueous solution: Dissolve 0.2g of 12μm hydroxyapatite (HA) powder in 10mL of secondary water, and shake and stir to make it fully dissolved, that is, a concentration of 0.02g / mL is obtained. Milky white HA solution;

[0045] (2) Preparation of graphene oxide (GO) aqueous solution: Dissolve 0.02g of graphene oxide (GO) powder in 10mL of secondary water, then shake and stir to make it fully dissolved, then a black and translucent GO solution with a concentration of 0.002g / mL is obtained ;

[0046] (3) Preparation of chitosan (CS) aqueous solution: Dissolve 0.1g of chitosan (CS) powder in 10mL of secondary water, then add 0.2mL of acetic acid, and finally shake and stir to make it fully and quickly dissolved, that is, the concentration is 0.01 g / mL milky yellow CS solution;

[0047] (4) Preparation of cross-linking agent aqueous sol...

Embodiment 3

[0064] Example 3: Preparation method of chitosan / graphene oxide / hydroxyapatite / polyacrylamide composite material

[0065] (1) Prepare hydroxyapatite (HA) aqueous solution: Dissolve 0.4g hydroxyapatite (HA) powder of 12μm in 10mL of secondary water, and shake and stir to make it fully dissolved, that is, a concentration of 0.04g / mL is obtained Milky white HA solution;

[0066] (2) Preparation of graphene oxide (GO) aqueous solution: Dissolve 0.02g of graphene oxide (GO) powder in 10mL of secondary water, then shake and stir to make it fully dissolved, then a black and translucent GO solution with a concentration of 0.002g / mL is obtained ;

[0067] (3) Preparation of chitosan (CS) aqueous solution: Dissolve 0.1g of chitosan (CS) powder in 10mL of secondary water, then add 0.2mL of acetic acid, and finally shake and stir to make it fully and quickly dissolved, that is, the concentration is 0.01 g / mL milky yellow CS solution;

[0068] (4) Preparation of cross-linking agent aqueous solu...

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Abstract

The invention discloses a preparation method of a chitosan / graphene oxide / hydroxyapatite / polyacrylamide composite material, belonging to the field of polymer materials. In this method, hydroxyapatite (HA), chitosan (CS) and graphene oxide (GO) are formulated into a solution, and then doped into a polyacrylamide (PAM) network structure. This method is not only easy to operate and cost-saving in the preparation process, but also the obtained composite material overcomes the characteristics of polyacrylamide (PAM) scaffolds that are easy to bend and has poor mechanical properties, and retains the low cytotoxicity and drug-loading properties of graphene oxide (GO). Strong ability and good biocompatibility of chitosan (CS) / hydroxyapatite (HA). Therefore, the composite material can be used as a bone repair material and is expected to be applied in bone tissue engineering.

Description

technical field [0001] The invention relates to a preparation method of a chitosan / graphene oxide / hydroxyapatite / polyacrylamide composite material, belonging to the technical field of polymer materials. Background technique [0002] Due to its good biocompatibility, polyacrylamide (PAM) hydrogel has aroused widespread interest in the biological application community, and the biological application community uses it in the fields of tissue engineering scaffold materials, cartilage tissue replacement materials, drug carriers, etc. ( J.P. Gong, AdvancedMateriaLs , 2003, 15, 1155-1158). In particular, hydrogel scaffolds with certain strength have been applied to the research and development of products such as bone, cartilage and muscle. The strength of the hydrogel has a certain relationship with the degree of cross-linking of the gel and its use conditions. However, the general hydrogel lacks an effective energy dissipation mechanism due to the widely distributed long chains...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/02A61L27/12A61L27/52
Inventor 王艳芹武晓刚于维伦岑海鹏郭媛张永刚陈维毅
Owner 星途(常州)碳材料有限责任公司
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