Raw material composition for preparing starch matrix hollow capsule and starch matrix hollow capsule

A raw material composition and a technology for hollow capsules, which are applied in the field of starch matrix hollow capsules, can solve the problems of difficulty in removing water, high strength, and no product, and achieve the advantages of increasing hydrophilic performance, overcoming hydrogen bonding force, and good disintegration performance. Effect

Inactive Publication Date: 2015-01-28
江苏崇尚生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, in the production process of preparing hollow capsules with it as the main raw material, the glue water material is relatively large, and it is difficult to remove water, and the glue paste is long and difficult to form. Large, the disintegration time of hollow capsules prepared with it as the main raw material is relatively long, therefore, the current domestic market share is not high
The price of starch is very low, and it is very attractive to prepare hollow capsules with it. Many domestic manufacturers have also applied for patents for starch hollow capsules. However, because starch molecules are easy to form strong hydrogen bonds, the starch film is brittle and fragile. It is difficult to make hollow capsules with high strength and resistance to filling
In recent years, some American and Japanese patents have prepared hollow capsule shells with higher strength by adding high-strength gels to the starch matrix, but at the same time, it has also caused the hollow capsule shells to be difficult to disintegrate, and it is difficult to obtain rapid disintegration in the body. product
Therefore, although there are many patents, there is no product that can be pushed to the market so far.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 94.5wt% of hydroxypropyl cornstarch (substitution degree DS is 0.05, hydroxypropyl cornstarch is prepared by cornstarch and propylene oxide through the conventional reaction method of starch industry), 5wt% of hydroxypropyl-β- Cyclodextrin (substitution degree DS is 3.64) is mixed with 0.5wt% konjac gum to prepare a raw material composition for preparing starch-based hollow capsules.

[0021] The above-mentioned raw material composition for preparing starch-based hollow capsules is mixed with water that is 6 times the weight of the raw material composition, and after gelatinization and gelatinization at a temperature of 80° C. for 90 minutes, the conventional method for preparing capsules is used. The starch-based hollow capsules with good flexibility and good disintegration properties were prepared by the process.

[0022] The prepared starch-based hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia...

Embodiment 2

[0024] 94.5wt% of hydroxypropyl tapioca starch (substitution degree DS is 0.2, hydroxypropyl tapioca starch is prepared from tapioca starch and propylene oxide through the conventional reaction method of starch industry), 1wt% of hydroxypropyl-β- Cyclodextrin (substitution degree DS is 4) is mixed with 4.5wt% carrageenan to prepare a raw material composition for preparing starch-based hollow capsules.

[0025] Mix the above-mentioned raw material composition for preparing starch-based hollow capsules with water that is 3 times the weight of the raw material composition, heat at 99°C for 15 minutes to gelatinize and gelatinize, and then prepare capsules using conventional methods. Starch-based hollow capsules with good flexibility and good disintegration properties were prepared by the process.

[0026] The prepared starch-based hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010, using Tianda Tianfa...

Embodiment 3

[0028] With 80wt% of hydroxypropyl potato starch (the degree of substitution DS is 0.21, hydroxypropyl potato starch is prepared by potato starch and propylene oxide through the conventional reaction mode of starch industry), 1wt% of hydroxypropyl-β-ring Dextrin (substitution degree DS is 5.33) is mixed with 19wt% guar gum to prepare a raw material composition for preparing starch-based hollow capsules.

[0029] Mix the above-mentioned raw material composition for preparing starch-based hollow capsules with water that is 6 times the weight of the raw material composition, heat at 85°C for 40 minutes to gelatinize and gelatinize, and then adopt the conventional process for preparing capsules The starch-based hollow capsules with good flexibility and good disintegration properties were prepared.

[0030] The prepared starch-based hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010, using Tianda Tianfa...

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Abstract

The invention relates to manufacture of a hollow capsule for food and medicine, in particular to a raw material composition for preparing a starch matrix hollow capsule, and the starch matrix hollow capsule prepared from the raw material composition and easy for rapid disintegration. The raw material composition for preparing starch matrix hollow capsule of the invention is the prepared by mixing hydroxypropyl starch, hydroxypropyl-beta-cyclodextrin and a gelling agent. The raw material composition is mixed with water, heated, gelatinized and gelatinized, so as to prepare the starch matrix hollow capsule. The invention introduces a proper amount of hydroxypropyl-beta-cyclodextrin with excellent water solubility into the raw material composition, so that the prepared starch matrix hollow capsule has good disintegration performance and does not affect the capsule strength.

Description

technical field [0001] The invention relates to the manufacture of hollow capsules used in the fields of food, medicine and the like, in particular to a raw material composition for preparing starch-based hollow capsules, and a starch-based hollow capsule that is easily and rapidly disintegrated prepared from the raw material composition. Background technique [0002] The use of animal-derived gelatin to make hollow capsules has a history of at least nearly 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L3/08C08L5/16C08L5/00C08L5/06
Inventor 闫丰文袁国卿闫芳丁赤民
Owner 江苏崇尚生物科技有限公司
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