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Injectable nano-hydroxyapatite/chitosan composite hydrogel as well as preparation method and application thereof

A technology of composite hydrogel and hydroxyphosphate, which is applied in the fields of medical science and prostheses, can solve the problems of insufficient mechanical properties of chitosan hydrogel, uneven distribution of inorganic phases of composite materials, and difficult nano-enhanced effects, etc. Achieve the effect of enhancing interfacial bonding force and dispersion, improving agglomeration and high mechanical properties

Active Publication Date: 2015-02-04
广州睿康医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, at home and abroad, the two are only compounded by physical blending. This method can solve the problem of insufficient mechanical properties of chitosan hydrogel to a certain extent, but nano-hydroxyapatite is prone to agglomeration due to its small particle size. phenomenon, resulting in uneven distribution of the inorganic phase in the composite material, so it is difficult to achieve the nano-reinforcement effect of nano-hydroxyapatite on chitosan materials by simple solution blending method

Method used

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  • Injectable nano-hydroxyapatite/chitosan composite hydrogel as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0025] A kind of injectable nano-hydroxyphosphate / chitosan composite hydrogel of the present embodiment is obtained by the following preparation method:

[0026] (1) Dissolve 1.37ml of silane coupling agent 3-aminopropyltriethoxysilane in a mixed solvent of 137ml of ethanol and water (volume ratio ethanol:water=9:1), hydrolyze for 0.5h at room temperature, and then 2g of hydroxyapatite with an average particle size of 100nm was added to the above solution, stirred and reacted for 0.5h under microwave-assisted conditions, and the product obtained by centrifugation was dried at 25°C for 24h, then heated to 120°C and dried for 2h, then washed with ethanol, vacuum After drying, hydroxyapatite (HA-APTES) containing amino groups on the surface is obtained;

[0027] (2) Dissolve 0.62ml of glutaraldehyde (GD) solution (aqueous solution with a volume fraction of 50%) in 62ml of deionized water, then add the above product (HA-APTES) to the glutaraldehyde aqueous solution, under microwav...

Embodiment 2

[0032] A kind of injectable nano-hydroxyphosphate / chitosan composite hydrogel of the present embodiment is obtained by the following preparation method:

[0033] (1) Dissolve 2.28ml of silane coupling agent 3-aminopropyltriethoxysilane in a mixed solvent of 228ml of ethanol and water (volume ratio ethanol:water=9:1), hydrolyze for 0.5h at room temperature, and then 2g of hydroxyapatite with an average particle size of 150nm was added to the above solution and mixed evenly, stirred by microwave for 1h, centrifuged and dried at 40°C for 24h, then heated to 100°C for 4h, washed with ethanol, and dried in vacuum Finally, hydroxyapatite (HA-APTES) containing amino groups on the surface is obtained;

[0034] (2) Dissolve 1.03ml of glutaraldehyde (GD) (aqueous solution with a volume fraction of 50%) in 103ml of deionized water, then add the above product (HA-APTES) into the glutaraldehyde aqueous solution, and microwave-assisted stirring reaction for 1h , and then centrifuged, washe...

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Abstract

The invention belongs to the technical field of a biomaterial, and discloses injectable nano-hydroxyapatite / chitosan composite hydrogel as well as a preparation method and application thereof. The preparation method comprises steps of reacting hydroxyapatite and an aminosilane coupling agent to obtain hydroxyapatite with an amino group on the surface, then reacting with glutaraldehyde to obtain hydroxyapatite with an aldehyde group on the surface, conducting a chemical reaction with chitosan to obtain chitosan modified hydroxyapatite, finally dispersing in a chitosan water solution and gelatinizing to obtain the injectable nano-hydroxyapatite / chitosan composite hydrogel. The finished product prepared by the invention has the characteristics of uniform structure, good stability and high mechanical property, and is applicable to repairing and replacing of bone tissues.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to an injectable nano-hydroxyphosphate / chitosan composite hydrogel and a preparation method and application thereof. Background technique [0002] The nano-hydroxyapatite / chitosan composite hydrogel combines the osseointegration ability of hydroxyapatite with the absorbability and degradability and easy processing of chitosan, so that this composite system has both osseointegration ability and Due to its biodegradability, it has received extensive attention from researchers. At present, at home and abroad, the two are only compounded by physical blending. This method can solve the problem of insufficient mechanical properties of chitosan hydrogel to a certain extent, but nano-hydroxyapatite is prone to agglomeration due to its small particle size. phenomenon, resulting in uneven distribution of inorganic phase in the composite material, so it is difficult to realiz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/52
Inventor 屠美曾戎查振刚杨慎宇吴昊
Owner 广州睿康医疗科技有限公司