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Preparation method of lutein effervescent tablets

A technology for effervescent tablets and lutein, which can be used in food preparation, pharmaceutical formulations, antidote and other directions, and can solve the problems of reduced biological activity and limited application.

Inactive Publication Date: 2015-02-11
天津新济复兴药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the existence of ten conjugated double bonds in the chemical structure of lutein, light and heat can easily lead to denaturation and reduce its biological activity, thus limiting its application in the pharmaceutical and food industries
Due to these properties of lutein, there are great limitations in their production, processing and application

Method used

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  • Preparation method of lutein effervescent tablets
  • Preparation method of lutein effervescent tablets
  • Preparation method of lutein effervescent tablets

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Example 1: its formula consists of (1000 tablets)

[0020]

[0021] Preparation:

[0022] First crush the material through a 100-mesh sieve, mix lutein, mannitol, and citric acid, add starch slurry to make a soft material, granulate with a 16-mesh sieve, dry at 60°C for 4-5 hours, and still use a 16-mesh Sieve for granulation and set aside; take another sodium bicarbonate plus zeaxanthin, PEG6000 and an appropriate amount of starch slurry to make a soft material, granulate with a 16-mesh sieve, dry at 60°C for 4-5 hours, and still use a 16-mesh sieve for granulation. After mixing the granules, press into tablets.

example 2

[0023] Example 2: its formula consists of (1000 tablets)

[0024]

[0025] Preparation:

[0026] First crush the material through a 100-mesh sieve, mix lutein, tartaric acid, sodium bicarbonate, and cross-linked carboxymethyl starch sodium, and then add 5% zeaxanthin-containing PVP-K30 absolute ethanol solution to make a soft material. Granulate with a 16-mesh sieve, dry at 80°C for 2 hours, sieve the granules with a 16-mesh sieve, add flavoring agent, lemon essence, and talcum powder, mix well, and press into tablets.

example 3

[0027] Example 3: its formula consists of (1000 tablets)

[0028]

[0029]

[0030] Preparation:

[0031] First crush the material through a 100-mesh sieve, mix lutein, sucrose, citric acid, sodium bicarbonate, and sodium carbonate, and then add 5% PVP-K30 absolute ethanol solution containing zeaxanthin to make a soft material. Granulate with a 16-mesh sieve, dry at 80°C for 2 hours, granulate with a 16-mesh sieve, add flavoring agent and magnesium lauryl sulfate, mix well, and press into tablets.

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PUM

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Abstract

The invention discloses lutein effervescent tablets for prevention and treatment of retinal macular degeneration and a preparation method thereof. Through scientific proportion of water-soluble lutein and zeaxanthine and through prescription screening, the weight percentage of the lutein with an antioxidant effect is determined to be 0.2-20%, and the weight percentage of auxiliary materials is determined to be 80-99.8%. Each sheet of the antioxidant lutein effervescent tablets preferably contains 2-20 mg of the lutein with the antioxidant effect. The ratio of the lutein with the antioxidant effect to zeaxanthine is 2:1. The novel effervescent preparation which is easy to store and carry, rapid in disintegration, convenient to take, fast in acting and high in bioavailability is obtained.

Description

technical field [0001] The invention belongs to the technical fields of medicine, food, beverage and the like, in particular, the invention relates to a preparation method of lutein effervescent tablet. Background technique [0002] Lutein is a carotenoid, a natural pigment, with bright color, strong tinting power, good anti-oxidation, safe and non-toxic, and rich in nutritional value. It is a natural substance that widely exists in vegetables, flowers, fruits and some algae plants, and is widely used in many fields such as food, health care products, cosmetics, medicine, tobacco and animal and poultry feed. The U.S. Food and Drug Administration has approved lutein as a food supplement for use in food as early as 1995. Due to the wide application of lutein, in the international market, 1g of lutein is equivalent to 1g of gold, so it has the reputation of "plant gold". [0003] The results of the latest research show that lutein can protect vision. In addition, it also has ...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/047A61P39/06A23L1/29A23L2/40A23L33/00
Inventor 崔景柏吴传斌梁华辉张乃军
Owner 天津新济复兴药业科技有限公司
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