High-stability astaxanthin ester self-microemulsion and preparation method thereof

A technology of astaxanthin ester and self-microemulsion, which is applied in the directions of food preparation, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of poor water solubility and poor storage stability of astaxanthin ester, and achieves good stability and simple production process. , the effect of inhibiting degradation

Active Publication Date: 2015-02-18
OCEAN UNIV OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a high stability astaxanthin ester self-microemulsion and its preparation method, thereby solving the two technical problems of poor water solubility and poor storage stabilit

Method used

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  • High-stability astaxanthin ester self-microemulsion and preparation method thereof
  • High-stability astaxanthin ester self-microemulsion and preparation method thereof
  • High-stability astaxanthin ester self-microemulsion and preparation method thereof

Examples

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Embodiment 1

[0035] Using the astaxanthin ester crude extract derived from Haematococcus pluvialis as raw material, wherein the astaxanthin ester content is 7% (purchased from Yunnan Aierfa Biological Engineering Co., Ltd.), weigh 1g of the astaxanthin ester crude extract and 0.1g of tocopheryl acetate, then dissolved in 3ml of ethyl acetate to make astaxanthin ester-tocopheryl acetate-ethyl acetate solution; take 1ml of the above astaxanthin ester-tocopheryl acetate-ethyl acetate Add 4ml of mixed emulsifier (Tween 80 / ethanol 2:1) to the ester solution, stir evenly at 40°C, then add 10ml of pH7.0 phosphate buffer solution, and homogenize at high speed to obtain high-stable astaxanthin ester From the microemulsion, observe the appearance of the system and measure the particle size and stability, the results are as follows: the emulsion appearance is clear and transparent, and the average particle size distribution is 61nm (such as figure 2 Shown), illustrate that the present embodiment 1 p...

Embodiment 2

[0037] The astaxanthin ester crude extract derived from Haematococcus pluvialis was used as raw material, wherein the astaxanthin ester content was 7% (purchased from Yunnan Aierfa Bioengineering Co., Ltd.), and 1g of the astaxanthin ester crude extract was weighed, Then dissolve it with 3ml of ethyl acetate to form astaxanthin ester-ethyl acetate solution; take 1ml of the above astaxanthin ester-ethyl acetate solution, add 4ml of mixed emulsifier (Tween 80 / ethanol 2:1), and Stir evenly at 40°C, then add 10ml of pH 7.0 phosphate buffer solution pre-dissolved with 0.1g of ascorbic acid, homogenize at high speed to obtain a highly stable astaxanthin ester self-microemulsion, observe the appearance of the system and measure the particle size and stability properties, the results are as follows: the emulsion appearance is clear and transparent, and the average particle size distribution is 65nm, indicating that the present embodiment 1 prepares a highly water-soluble self-microemul...

Embodiment 3

[0039]The astaxanthin ester crude extract derived from Haematococcus pluvialis was used as raw material, wherein the astaxanthin ester content was 7% (purchased from Yunnan Aierfa Bioengineering Co., Ltd.), and 1g of the astaxanthin ester crude extract was weighed, Then dissolve it with 3ml of ethyl acetate to form astaxanthin ester-ethyl acetate solution; take 1ml of the above astaxanthin ester-ethyl acetate solution, add 4ml of mixed emulsifier (Tween 80 / ethanol 2:1), and Stir evenly at 40°C, then add 10ml of pH 7.0 phosphate buffer solution pre-dissolved with 0.1g of ethylenediaminetetraacetic acid, homogenize at high speed to obtain a highly stable astaxanthin ester self-microemulsion, observe the appearance of the system and measure Particle size and stability, the results are as follows: the emulsion appearance is clear and transparent, and the average particle size distribution is 63nm, illustrating that the present embodiment 1 prepares a highly water-soluble self-micro...

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Abstract

The invention provides a preparation method of a high-stability astaxanthin ester self-microemulsion. The high-stability astaxanthin ester self-microemulsion is prepared by mixing astaxanthin ester, carrier oil, a stabilizing agent, an emulsifying agent, an auxiliary emulsifying agent with a water phase under special process conditions according to a certain proportion, and then, distilling at low pressure to remove a solvent. The astaxanthin ester self-microemulsion prepared by the invention can be self-microemulsified in a water-phase medium to form transparent microemulsion, the particle diameter of which is within 100 nm; the solubility of astaxanthin ester in water is increased; simultaneously, the storage stability of astaxanthin ester is obviously increased; the two problems of being water-fast and low in stability of astaxanthin ester are solved; and thus, astaxanthin ester is possibly applied in water-phase foods, drugs and daily chemical products.

Description

technical field [0001] The invention belongs to the technical field of preparation of active substance preparations, and in particular relates to a high-stable astaxanthin ester self-microemulsion and a preparation method thereof. Background technique [0002] Astaxanthin, also known as astaxanthin and lobster shell pigment, has a chemical name of 3,3'-dihydroxy-β,β-carotene-4,4'-dione, and its molecular formula is C 40 h 52 o 4 , with a relative molecular mass of 596.86, widely present in marine animals and plants, because astaxanthin has various biological functions such as anti-oxidation, anti-inflammation, coloration, light protection, and promotion of reproduction, it has become very popular in food and medicine at home and abroad in recent years. , cosmetics, aquaculture and other industries. Studies have found that in nature, more than 90% of astaxanthin exists in the form of esterification, and astaxanthin esters are more stable than free astaxanthin. And the pre...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/215A61K8/37A61K8/06A23L1/29A23L1/272A23L5/41A23L33/00
Inventor 薛长湖周庆新王玉明徐杰常耀光李学敏尹利昂
Owner OCEAN UNIV OF CHINA
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