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A kind of water-soluble magnetic titanium dioxide and its preparation method and application

A titanium dioxide, water-soluble technology, applied in the field of medicine, can solve the problems of narrow light absorption range, low biocompatibility, low photocatalytic activity, reduce damage to normal tissues, have huge economic and social benefits, overcome non-target Tropical Difficulty Effects

Inactive Publication Date: 2016-09-14
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The technical solution solved by the present invention is to provide a water-soluble polymer-modified magnetic titanium dioxide with anti-tumor photodynamic therapy activity, tumor cell targeting, tumor site MRI function and good biocompatibility, which can effectively solve the problem of The existing titanium dioxide has a wide band gap, low photocatalytic activity, narrow light absorption range, instability in water, low biocompatibility, poor targeting and application problems in magnetic resonance contrast agents. In addition, it can be loaded with anti-tumor activity drugs, together to achieve the effect of treating cancer, at the same time, the present invention also provides the above-mentioned water-soluble magnetic titanium dioxide and water-soluble magnetic titanium dioxide pharmaceutical composition and its preparation method and provides the above-mentioned water-soluble magnetic titanium dioxide and its pharmaceutical composition in the field of medicine Applications

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  • A kind of water-soluble magnetic titanium dioxide and its preparation method and application

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Embodiment 1

[0023] The water-soluble magnetic titanium dioxide referred to in the present invention is formed by doping ferric oxide in titanium dioxide molecules and chemically connecting hydrophilic groups, and its preparation method is realized by the following steps:

[0024] (1) Preparation of magnetic ferric oxide nanoparticles (IONP):

[0025] Weigh FeCl 3 .6H 2 O 5.40g, add 200ml of distilled water, after all the solids are dissolved, filter with fast filter paper, remove insoluble matter, and form the first solution A; weigh FeSO 4 ·7H 2 O 2.92g, add 180ml of distilled water, after all the solids are dissolved, filter with fast filter paper, remove insoluble matter, and form the second solution B; pour the first solution A and the second solution B into a 500ml beaker, add a mass concentration of 50% hydrochloric acid, adjust the pH of the solution to 1-2, add 0.43g of trisodium citrate, stir evenly to obtain a mixed solution, place the mixed solution on a hot plate and heat i...

Embodiment 2

[0033] The water-soluble magnetic titanium dioxide of the present invention can also be realized by the following steps in specific implementation:

[0034] (1) Preparation of magnetic ferric oxide nanoparticles (IONP):

[0035] Dissolve 7.00 g of ferric salt in 175 ml of distilled water, filter to remove insoluble matter, and obtain the first solution A; dissolve 3.59 g of ferric salt in 150 ml of distilled water, filter, and remove insoluble matter to obtain the second solution B; Mix the first solution A and the second solution B, adjust the pH of the solution to 1-2 with hydrochloric acid, add 0.59g of trisodium citrate, stir well to obtain a mixed solution, heat the mixed solution to 70°C-80°C, and keep stirring Then drop ammonia water until the pH of the mixed solution is 8.8-9.2; let it settle for 30-60 minutes, discard the supernatant to obtain a precipitate, wash the precipitate with distilled water 3-4 times, and then wash with ethanol until the solution is Neutral,...

Embodiment 3

[0043] The water-soluble magnetic titanium dioxide of the present invention can also be realized by the following steps:

[0044] (1) Preparation of magnetic ferric oxide nanoparticles (IONP):

[0045] Dissolve 8.6g of ferric salt in 190ml of distilled water, filter to remove insoluble matter, and obtain the first solution A; add 4.2g of ferrous salt into 170ml of distilled water to dissolve, filter, and remove insoluble matter to obtain the second solution B; Mix the first solution A and the second solution B, adjust the pH of the solution to 1-2 with hydrochloric acid, add 0.7g of trisodium citrate, stir well to obtain a mixed solution, heat the mixed solution to 70°C-80°C, and keep stirring Then drop ammonia water until the pH of the mixed solution is 8.8-9.2; let it settle for 30-60 minutes, discard the supernatant to obtain a precipitate, wash the precipitate with distilled water 3-4 times, and then wash with ethanol until the solution is Neutral, get magnetic ferric oxi...

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Abstract

The invention relates to water-soluble magnetic titanium dioxide and a preparation method and an application thereof. The problem of medication for treating tumors can be effectively solved. The water-soluble magnetic titanium dioxide is formed by doping ferroferric oxide into titanium dioxide molecules and chemically bonding with a hydrophilic group, wherein the mass content ratio of titanium dioxide to ferroferric oxide is (1-10) to (10-1); titanium dioxide is rutile or anatase titanium dioxide; and the particle size of the water-soluble magnetic titanium dioxide is 1-1000nm. The water-soluble magnetic titanium dioxide is simple in synthetic process; significant light dynamic characteristics of titanium dioxide, and unique tumor cell magnetic targeting, auxiliary anti-tumor activity and nuclear magnetic imaging function of Fe3O4 are organically integrated into a whole; the water-soluble magnetic titanium dioxide is capable of physically loading the medicine with the antitumor activity, thereby overcoming the non-targeted problem of traditional tumor treatment, and reducing injuries to normal tissue in the treatment process; and the water-soluble magnetic titanium dioxide has efficient and controllable advantages in comparison with traditional tumor treatment, and is an innovation in medicines for treating tumors.

Description

technical field [0001] The invention relates to medicine, in particular to a water-soluble magnetic titanium dioxide and its preparation method and application. Background technique [0002] Malignant tumors have surpassed cardiovascular diseases and become the leading cause of death for urban residents, seriously threatening human life and health. At present, surgery, radiotherapy, and chemotherapy constitute the three major means of tumor treatment. However, surgery can only remove tumors that are visible to the naked eye, but it is difficult to remove invisible subclinical lesions; traditional chemotherapy often has the problems of poor targeting and dose-limiting toxicity. A new type of treatment that has emerged after chemotherapy and radiation. [0003] Titanium dioxide (Ti0 2 ) is a commonly used photocatalyst, which has the advantages of high catalytic activity, good chemical and light stability, safety, non-toxicity, cheap and easy to obtain, and is therefore wid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/12A61K47/04A61P35/00
Inventor 张振中张慧娟冀嫣丹侯琳焦晓静陈倩倩张红岭
Owner ZHENGZHOU UNIV
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