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A kind of preparation method and application of carboxymethyl pachyranan

A technology of carboxymethyl-polysaccharide and carboxymethyl-poria cocos, which is applied in the field of natural medicinal chemistry, can solve the problems of other effects and applications that have not been reported, long duration, low efficiency, etc., to improve vaccine immunity and response time Short, easy-to-manipulate effects

Active Publication Date: 2017-01-04
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the equipment and reaction medium have been greatly improved, the duration of the reaction is too long, generally takes forty or fifty hours, and the efficiency is low
[0006] At the same time, the current research on the application of carboxymethylpachyran only involves the anti-tumor application of human medicine, and there are no relevant reports on other effects and applications.

Method used

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  • A kind of preparation method and application of carboxymethyl pachyranan
  • A kind of preparation method and application of carboxymethyl pachyranan
  • A kind of preparation method and application of carboxymethyl pachyranan

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Embodiment 1

[0043] Embodiment 1 (the preparation method of carboxymethyl pachymane)

[0044] A method for preparing carboxymethyl pachyrhin, specifically comprising the following steps:

[0045] Take 1000g of Poria cocos sclerotia, dry and pulverize to obtain Poria cocos micropowder; add Poria cocos micropowder to 6L, 80% benzyl alcohol solution, stir evenly, add 150g of sodium hydroxide, stir for 1 hour, obtain Poria cocos polysaccharide extract; 150g of hydroxide Add sodium to chloroacetic acid and react for 1 hour to obtain chloroacetic acid alkalization solution; add chloroacetic acid alkalinization solution to the extract of pachyrhiza polysaccharide, add 100 g of polyethylene glycol to the reaction solution, and fully stir at 50°C for 3 hours Carry out the substitution reaction, after the reaction is finished, adjust the solution to neutral, collect the precipitate by filtration, wash thoroughly with absolute ethanol three times, and filter and dry to obtain carboxymethylpachyan.

Embodiment 2

[0046] Embodiment 2 (the preparation method of carboxymethyl pachymane)

[0047] A method for preparing carboxymethyl pachyrhin, specifically comprising the following steps:

[0048] Take 1000g of Poria cocos sclerotia, dry and pulverize to obtain Poria cocos micropowder; add Poria cocos micropowder to 13.7L, 95% glycerol solution, stir evenly, add 250g of sodium hydroxide, stir for 5h, and obtain Poria cocos polysaccharide extract; mix 250g Sodium hydroxide is added in the chloroacetic acid and reacts 5h, obtains chloroacetic acid basification liquid; Chloroacetic acid basification liquid is joined in the Poria cocos polysaccharide extraction liquid, adds 200g benzyltriethyl ammonium chloride in reaction solution, in Thoroughly stir at 80°C for 6 hours to carry out the substitution reaction. After the reaction, adjust the solution to neutrality, collect the precipitate by filtration, wash thoroughly with absolute ethanol three times, and filter and dry to obtain carboxymethyl...

Embodiment 3

[0049] Embodiment 3 (the preparation method of carboxymethyl pachymane)

[0050] A method for preparing carboxymethyl pachyrhin, specifically comprising the following steps:

[0051] Take 1000g of Poria cocos sclerotia, dry and pulverize to obtain Poria cocos micropowder; add Poria cocos micropowder to 10L, 85% propanol solution, stir evenly, add 200g of sodium hydroxide, stir for 3 hours to obtain Poria cocos polysaccharide extract; 200g of hydroxide Sodium was added in the chloroacetic acid and reacted for 3h to obtain the chloroacetic acid alkalization solution; the chloroacetic acid alkalization solution was added in the polysaccharide extract, and 150g chain polyethylene glycol dialkyl ether was added to the reaction solution, and the Fully stir at 65°C for 4.5 hours to carry out the substitution reaction. After the reaction, adjust the solution to neutrality, collect the precipitate by filtration, wash thoroughly with absolute ethanol three times, and filter and dry to o...

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Abstract

The invention provides a preparation method and new application of carboxymethylpachyan. In the process of carrying out carboxymethylation modification of polysaccharides, by changing the composition and proportion of the reaction medium, adjusting the reaction temperature, and using catalyst technology, the efficiency of carboxymethylation of polysaccharides is significantly improved, and the ratio of raw and auxiliary materials is improved. Utilization rate saves cost. At the same time, the new application of carboxymethyl pachyrhiza provided by the present invention in the preparation of livestock and poultry immune enhancers can significantly improve the immunity of livestock and poultry when dealing with pathogenic microorganisms, and improve the immune efficacy of vaccines; The new application of the provided carboxymethylpachyran as a feed additive can effectively improve the meat production performance of livestock and poultry.

Description

technical field [0001] The invention relates to the technical field of natural medicine chemistry, in particular to a preparation method of carboxymethyl pachymane and its new application. Background technique [0002] Poria [Poria cocos (Schw.) Wolf] is a fungus used for food and medicine. It is one of the "four monarchs and eight treasures" of traditional Chinese medicine. Tumor, diuresis and swelling, enhance immunity, calm the nerves and inhibit bacteria and other functions. Poria cocos contains a variety of chemical components, the most important of which is polysaccharide, and its content can reach 84% of the dry weight of Poria cocos. Poria cocos polysaccharide has a wide molecular weight distribution, the large molecular weight can reach 1 million Daltons, and the small molecular weight ones are distributed between 5000-9000 Daltons. Poria cocos polysaccharide is easily soluble in medium and strong alkaline solutions, but hardly soluble in water. Its main structure...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A23K20/163A61K31/715A61K39/39A61K39/245A61P31/22A61P37/04
Inventor 彭江宁赵越超夏雪林刘拓刘爱玲李旭东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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