69 results about "IMMUNE ENHANCEMENT AGENTS" patented technology

The invention discloses a method for producing a forage immune enhancer by adopting a soybean curb residue and an orange peel. The method comprises the following steps: respectively crushing the soybean curb residue, dried pine needles, dry dunaliella cells and dry orange peel into coarse powder of 60-80 meshes; burdening the raw materials in parts by weight: 45-50 parts of soybean curb residue, 30-35 parts of dried pine needles, 2-5 parts of dry dunaliella cells, 15-18 parts of dry orange peel and 2.0-2.5 parts of an assistant, wherein the assistant is prepared from 49 parts of NaHCO3 and 1 part of MgSO4; the moisture content of the pine needles, the dunaliella cells and the orange peel is 3-5%, the moisture content of bean dregs is 18-20%; mixing the mixture of four coarse powder with the assistant according to the ratio, wherein the assistant accounts for 2.0-2.5% of dry weight of the total material; evenly mixing and then grinding for 30 minutes; filtering by a 400-mesh sieve; processing by using enzyme-aid micronization treatment, so as to obtain the forage immune enhancer product, wherein the treatment time is 15-30 minutes according to the quality and the humidity of the raw materials. By adopting the forage immune enhancer produced by the method disclosed by the invention, the production cost of the raw materials is significantly reduced, a lot of waste bean dregs produced in bean product production are recycled, low-carbon production is achieved, and the added value of products is increased.

The invention provides an immunity enhancing agent, an inactivated vaccine, and a preparation method thereof. The invention relates to the field of biopharmaceutical. The immunity enhancing agent comprises 0.1-21mg / mL of monophosphoryl lipid A, 1.5-125mg / mL of muramyl dipeptide, and 0.7-4.5mg / mL of beta-glucan. The invention also provides the inactivated vaccine comprising the immunity enhancing agent, and a preparation method of the inactivated vaccine. According to the invention, the immunity enhancing agent is mixed with an inactivated antigen solution, such that a water-phase solution is obtained; and the water-phase solution is mixed with an oil-phase solution, such that the inactivated vaccine is obtained. According to the immunity enhancing agent provided by the invention, with a synergetic effect of the components, body immunity level can be improved, and immune response to antigen can be improved, such that antibody level after immunization can be increased, immune window period can be shortened, and vaccine immunization effect can be enhanced. According to the inactivated vaccine comprising the immunity enhancing agent, antibody level after immunization is high, a protection period is long, and immunization window period is short.

The invention relates to a nonspecific immunity enhancer for shrimps and crabs and a preparation method thereof, and belongs to the technical field of feed additive in the aquiculture industry. The immunity enhancer comprises the following components in weight percentage: 27 to 29 percent of radix isatidis, 15 to 17 percent of heroubill geranium, 7 to 9 percent of scutellaria, 7 to 9 percent of milk veteh, 7 to 9 percent of cordate houttuynia, 7 to 9 percent of dried orange peel, 3.5 to 4.5 percent of forsythia and the balance being yeast powder. The components are crushed to 100 meshes and added to basic bait according to a proportion of 1 to 2 percent, so as to improve nonspecific immunity of the shrimps and crabs remarkably, enhance phagocytosing function of blood cells of the shrimps and crabs, and effectively remove free radicals in vivo of the shrimps and crabs. Through activating self Pro proenzyme systems of the shrimps and crabs, the enhancer improves Pro enzyme activity remarkably and prevents cultivation diseases.

The technology belongs to the technical field of aquiculture disease prevention, in particular to the preparation method of the immune reinforcing agent for cultivating crustacean, and the applicationmethod thereof. The aquiculture composite immune reinforcing agent comprises 2-4 parts of aquiculture extractive or baicalin and 2.5-5 parts of levamisole. The composite immune reinforcing agent caneffectively enhance non-specific immunity for cultivating blue crab, improve the activity of the blood serum phenol oxidase, the superoxide dismutase and the alkalinephosphatase of the blue crab, andimproves the disease resistance of the blue crab to common pathogens such as white spot syndrome virus, vibrio, hematodinium, etc. The composite immune reinforcing agent can be applied to the cultivation of the blue crab by being injected or added into blue crab fresh fish bait and granulated feed for preventing and controlling the disease at the disease peak and reducing the disease rate and themortality rate of the blue crab. The immune reinforcing agent is added into the feed for preventing and controlling the disease of the penaeus vannamei boone and exopalaemon carinicauda.

A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a β-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it.The substance of the invention is improved in the physiological effect of the aglycone of isoflavones and the physiological effect of the culture of the basidiomycetes, and is not only useful as an anti-tumor agent but also is useful for therapy and / or prevention of osteoporosis and also as an immune enhancement agent.

Nanoparticles are prepared from curdlan sulfate and 6-O-quaternized chitosan by an ion gelation method for the first time; the method is simple and convenient, green, safe and pollution-free, and through controlling experimental steps and parameters, the prepared curdlan sulfate / 6-O-quaternized chitosan nanoparticles have uniform size and good stability. Evaluation of the membrane penetrating ability, the immune regulation ability and the mucosal adjuvant effect of the curdlan sulfate / 6-O-quaternized chitosan nanoparticles shows that the positively charged characteristic of the nanoparticles make the nanoparticles more easily act on effective parts through epithelium mucosae, so as to play a role of immune enhancers and help an antigen reach the effective parts to play relatively good immune adjuvant effect; the nanoparticles have great industrial application value.

The invention relates to a FOLATE-GSH-IgG conjugate, a preparation method thereof and application thereof in treating tumors and autoimmune diseases. FOLATE means Folate or analogs thereof. The FOLATE and glutathione (GSH) generate FOLATE-GSH through an amido bond; and meanwhile, the amino of an IgG tail end is activated, or the IgG is reduced into semi-antibody or heavy-chain antibody, and the two activated IgGs and the OLATE-GSH are conjugated to form FOLATE-GSH-IgG. The FOLATE-GSH-IgG conjugate can be specifically bonded with high-expression folate receptors on the surface of disease cells in cancer patients or autoimmune disease patients of high-expression type of folate receptors, enhances biological response adjustment through the IgG activated antibody or complement system mediated cytotoxin effect, and does not produce cytotoxin effect on hardly expressed normal cells of the folate receptors. The invention improves the target activities of an antibody medicament and an immune enhancement agent, and solves the harm problem of medicaments for treating cancers and autoimmune diseases on the normal cells.

The invention discloses a compound immunity enhancing agent for trachidermus fasciatus heckle. The compound immunity enhancing agent is prepared from the following components in parts by weight: 20-30 parts of ephedra sinica stapf, 10-15 parts of humifuse euphorbia herb, 5-10 parts of acorus calamus, 10-16 parts of an agrimonia pilosa ledeb extract, 4-8 parts of a galla chinensis extract, 10-20 parts of mulberry leaves, 1-5 parts of verbena officinalis L, 4-6 parts of a pulsatilla chinensis regel extract, 4-10 parts of pericarpium citri reticulatae, 1-3 parts of gardenia jasminoides ellis and 1-3 parts of ferula fukanensis. As an additive, the compound immunity enhancing agent for the trachidermus fasciatus heckle cooperates with a regular feed, so as to replace antibiotics; the compound immunity enhancing agent can prevent and treat all the year and the morbidity is reduced; all the components are used cooperatively so that various diseases including saprolegniasis, gill rot diseases, fixedness infusorian diseases and the like can be effectively prevented and treated; the organism immunity of the trachidermus fasciatus heckle can be enhanced by daily feeding and the resistance to diseases and insect pests is improved; the formula has no toxic or side effect or untoward effect and has no adverse effect on the palatability of the feed; and pericarpium citri reticulatae, gardenia jasminoides ellis and ferula fukanensis are compounded so that the feed calling effect and the effect of improving the palatability of the feed can be realized.

The present invention relates to a novel Pediococcus genus microorganism and more particularly, Pediococcus pentosaceus EROM101 (KCCM-10517) originated from human intestines having immune enhancement, anticancer and antiviral activities and a use thereof. Due to its excellent immune enhancement, anticancer and antimicrobial activities by activating macrophages / spleen cells and inducing gut immunity, the Pediococcus pentosaceus EROM101 of the present invention can be effectively used for the production of various products such as immune enhancement agent, anticancer agent, antimicrobial agent, food additive, intestinal function-controlling agent, live bacterial agent, feed additive and other fermented products.

The invention provides a fragment of CpG oligodeoxynucleotides sequence capable of stimulating proliferation activities of animal immunologic cells, and a method for packaging this fragment of CpG oligodeoxynucleotides to prepare anti-infection DNA nano granular formulation, the use of the CpG nano particles as novel anti-infection molecular immune enhancement agent is also disclosed. The method comprises packaging CpG oligodeoxynucleotides with chitosan nano particles, immunizing experimental animals with the prepared DNA nano granular formulation separately or synergically through intramuscular injection or oral administration, finally detecting the cell and body fluid immunity indexes of the experimental animal.

The invention discloses an immune enhancing agent. The agent comprises the ingredients of: fuling polysaccharide, safflower, vitamin C and probiotics. The invention provides a composite agent for improving effectively nonspecific immunity of procambarus clarkii so as to better meet the needs of the intensive cultivation of procambarus crayfish.

The present invention relates to a cyprinus carpio overwintering compound pellet feed and belongs to the technical field of fish feed. The feed includes the following components: fish meal 4-6 parts, meat meal 4-6 parts, corn gluten meal 2-5 parts, DDGS 4-8 parts, soybean meal 12-18 parts, extruded soybeans 6-8 parts, rapeseed meal 10-15 parts, cottonseed meal 3-6 parts, flour 12-16 parts, soybean oil 2-3 parts, calcium dihydrogen phosphate 1-1.5 parts, vitamin premix 0.5-1 part, trace element premix 1.5-2.5 parts, immune enhancer 0.3-0.5 part, bile acid additive 0.03-0.05 part, vitamin C phosphate 0.03-0.05 part, vitamin E 0.01-0.02 part, choline chloride 0.04-0.08 part and antioxidant 0.02-0.05 part. The feed improves the immunity of the cyprinus carpio during the overwintering period, and further improves the survival rate and yield of the cyprinus carpio after the overwintering period.

The invention relates to an efficacy nutritive cream for a fur-bearing animal and belongs to the technical field of feed. The efficacy nutritive cream comprises the following components by weight percent: 20 to 80 percent of egg yolk liquid containing specificity IgY (immune gloulin Y), 30 to 65 percent of soybean oil, 1 to 5 percent of plant-type immunity enhancer, 0.1 to 0.5 percent of vitamin E, 0.1 to 0.5 percent of vitamin C, 0.3 to 1 percent of copper, 0.3 to 1 percent of iron, 0.2 to 0.5 percent of potassium sorbate, 0.2 to 0.5 percent of ethoxyquin and 0.2 to 2 percent of white carbon black. The IgY component in the efficacy nutritive cream can specifically play a prevention and treatment effect on some diseases of the fur-bearing animal, and the plant-type immunity enhancer is beneficial to regulation of the immunity function of the fur-bearing animal and improvement of the disease resistance of the fur-bearing animal. The cream feed is innovatively applied to the fur-bearing animal, and the immunity, the survival rate and the fur quality of the fur-bearing animal can be improved after the fur-bearing animal takes the nutritive cream for a long time.

The invention relates to a takifugu obscures B lymphocyte stimulating factor (fuguTALL-1) cDNA and a cloning method and recombination application thereof, and belongs to the field of biological gene engineering. The gene of the takifugu obscures B lymphocyte stimulating factor has a sequence shown as SEQ ID No.1. The cloning method for the stimulating factor comprises the following steps of: designing primers according to the conserved sequence of the fuguTALL-1; extracting total RNA from the spleen of takifugu obscures; and amplifying a full-length cDNA sequence by a two-step reverse transcription-polymerase chain reaction (RT-PCR) method, cloning the full-length cDNA sequence into a pMD19-T vector, and picking positive clones to perform sequencing. The recombinant fuguTALL-1 serving as a fugu immunity enhancer can be produced from the cDNA of the takifugu obscures B lymphocyte stimulating factor by the conventional gene engineering method.

The invention discloses a feed for enhancing goose immunity and a preparation method thereof. The feed for enhancing goose immunity comprises the following raw materials in parts by weight: 40-60 parts of corn, 10-20 parts of soybean meal, 10-20 parts of wheat, 5-10 parts of rice bran, 3-5 parts of fish meal, 3-5 parts of shrimp shells, 35 parts of sorghum, 3-5 parts of carrots, 13 parts of sodiumchloride, 0.5-1 part of probiotics, 1-2 parts of an antibacterial phagostimulant, 3-5 parts of a reinforcing agent and 40-60 parts of water. Meanwhile, the probiotics and the enhancer which are addedinto the feed are good immune activators and immune enhancers, and an antibacterial phagostimulant is prepared, can penetrate through cell membranes of pathogenic bacteria to enter cytoplasm, destroynormal metabolism of the pathogenic bacteria, effectively play an antibacterial role, and can induce geese to eat to increase food intake; the immunity is further enhanced, and the problem of low goose immunity is effectively solved.

The invention relates to the technical field of nano-selenium hydrosols, in particular to a chitosan nano-selenium hydrosol with an immune enhancement effect and preparation, preservation and application. The chitosan nano-selenium hydrosol with the immune enhancement effect comprises the following components in concentration: 0.5mmol / L-5.0mmol / L of nano-selenium and 100.0mg / L-1000.0mg / L of functionalized chitosan. The chitosan nano-selenium hydrosol with the immune enhancement effect has immune activity, and can increase the selenium content in muscle tissue of aquatic organisms including fishes and the like; and when the chitosan nano-selenium hydrosol is added into aquatic organism feed and serves as an immune enhancer for aquatic organisms, a more effective scheme can be provided for disease control of aquaculture.

Disclosed are compounds for use in raising an immune response to an antigen and / or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

Disclosed are compounds for use in raising an immune response to an antigen and / or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

The present invention discloses a compound feed for young soft-shelled turtles. The compound feed comprises the following raw materials in parts by weight: 40-60 parts of sorghum, 15-25 parts of ricebran, 20-30 parts of carrot powder, 10-20 parts of oat flour, 80-90 parts of a protein additive, 2-6 parts of herba houttuyniae, 2-4 parts of allicin, 2-4 parts of fructus amomi, 1-3 parts of rhizomacoptidis, 2-4 parts of haws, 0.6-1.2 parts of an immune enhancement agent, 2-4 parts of montmorillonite, 1-3 parts of calcium hydrogen phosphate, 0.2-0.6 part of bacillus subtilis, 6-12 parts of pretreated cottonseed meal, 2-4 parts of oxidized starch and 3-6 parts of microcrystalline cellulose. The pretreated cottonseed meal is prepared by the following processes: the cottonseed meal and ethanolsolution are mixed evenly, a temperature is adjusted, sodium hydroxide is added, the materials are stirred evenly, Tween and coconut oil are added, the materials are mixed evenly, a first homogenization treatment, a temperature rising, a second homogenization treatment, and a still putting are conducted, a pH value of the materials is adjusted to be 6.5-6.9, a washing and a drying are conducted, and the materials are crushed to obtain the pretreated cottonseed meal.

A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a β-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it.The substance of the invention is improved in the physiological effect of the aglycone of isoflavones and the physiological effect of the culture of the basidiomycetes, and is not only useful as an anti-tumor agent but also is useful for therapy and / or prevention of osteoporosis and also as an immune enhancement agent.

The invention belongs to the field of aquatic animal breeding feed additives, and particularly relates to an immunity enhancing agent for resisting parasitic diseases of a snakehead as well as a preparation method and application thereof. The immunity enhancing agent for resisting the parasitic diseases is prepared by fermenting an immunity enhancing composition and fermentation bacteria powder; and the immunity enhancing composition comprises the following components: sulfur, areca-nut, cortex meliae, fructus gleditsiae, radix aucklandiae, licorice roots, cyrtomium rhizome, fried dry ginger,radix aconiti lateralis preparata, herba cistanche, radix astragali, radix codcnopsitis pilosulas, red peppers and hawthorn, the fermentation bacteria powder comprises lactobacillus acidophilus powder, bifidobacterium powder and saccharomycetes powder. The immunity enhancing agent for resisting the parasitic diseases can effectively expel and kill variousparasitesof costia necatrix, trichodina, chilodonella cyprini, coccidium, myxosporea and various the likeparasites inside and outside the snakehead bodies, can improve the immunity and the parasitic disease of the snakehead, and can increase the culture economic benefit.

A nutraceutical composition for protection against a wide spectrum of viral and bacterial infections and for treatment of established infection and infectious inflammation. The nutraceutical composition includes a novel combination of vitamin, mineral and herbal or other natural and organic supplements. The composition of supplements may be compounded as a pill, tablet, powder, capsule or liquid be taken orally one or more times per day. Vitamin C and vitamin E along with zinc complexed with pyrithione or citrate are used in conjunction with nutraceuticals provided as immune boosters and antiviral agents along with possible anti-inflammatory herbs or other anti-inflammatory substances.

The invention discloses the application of an Inonotus obliquus polysaccharide as a feed additive for Litopenaeus vannamei. The amount of the Inonotus obliquus polysaccharide added to the basic feed of Litopenaeus vannamei is 500-1500 mg / kg of the basic feed of Litopenaeus vannamei. In the invention, the Inonotus obliquus polysaccharide is used as an additive in the feed of Litopenaeus vannamei, which can significantly increase the weight gain rate and specific growth rate of Litopenaeus vannamei, significantly reduce the feed coefficient, and at the same time significantly increase the serum lysozyme, Alkaline phosphatase and total antioxidant capacity, increase serum nitric oxide synthase, superoxide dismutase, reduce serum malondialdehyde content, its effect is equivalent to β-glucan, is a new type of immune enhancer, It has broad application prospects in the field of Litopenaeus vannamei culture.

The invention discloses xenopus tropicalis interleukin 8 (XtIL-8) cDNA, a cloning method and recombination application thereof, relating to the field of biological genetic engineering. A gene of the XtIL-8 cDNA has a sequence shown in SEQ ID NO.1. The cloning method comprises the steps of: extracting total xenopus tropicalis spleen RNA by using a TRIzol method and carrying out reverse transcription; analyzing an XtIL-8 cDNA conversed region obtained from cloning of human, chicks, ducks, geese and electronics through Clustalw software, designing a specific primer for carrying out PCR (Polymerase Chain Reaction) amplification to obtain a 312bp amplification segment which is a full-length sequence of the XtIL-8 through sequencing. The XtIL-8 cDNA can be used for producing a recombinant XtIL-8 as an immune potentiator for amphibians through the traditional genetic engineering method.

The invention belongs to the technical field of aquaculture, and in particular relates to a special immune enhancer for red grouper. A special immune enhancer for red grouper, which is mainly composed of the following components by weight: 0.2-0.4 parts of β-glucan, 4-12 parts of Acanthopanax root, 5-10 parts 6-12 parts of dandelion, 12-15 parts of Kluyveromyces fragilis, 10-20 parts of Eucommia leaves, 5-10 parts of malt, 3-5 parts of astragalus extract, 65-80 parts of bamboo vinegar. In the aquaculture industry, the abuse of antibiotics can no longer be ignored. The special immune enhancer for red grouper of the present invention adopts pure natural plant ingredients and assists a small amount of β-glucan, which can effectively enhance the immune enhancer effect of the composition. Points do not contain antibiotics, avoiding a series of consequences caused by the abuse of antibiotics.

The invention discloses a method for constructing a screening model of an immune enhancer capable of promoting development of hemopoietic tissue of eriocheir sinensis. Based on the influence of hemopoietic factors of the eriocheir sinensis on the development of the hemopoietic tissue, through constructing a cell and animal screening model, the immune enhancer capable of specifically promoting thedevelopment of the hemopoietic tissue is screened, the effect of the immune enhancer is verified, and the immunity of the eriocheir sinensis is fundamentally increased as far as possible.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition with antibacterial and antiviral effects, a preparation method and application thereof. The composition consists of dandelion, Eucommia leaves, perilla leaves, astragalus and cinnamon. The composition of the present invention is formed through scientific compatibility, has remarkable antibacterial and antiviral effects, and is safe and has no side effects. It can be used as a poultry feed additive and immune enhancer for poultry feeding, and is in line with modern agricultural ecological safe breeding and sustainable development. basic requirements.