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Composite artificial endocranium and preparation method thereof

A technology of artificial dura mater and French silica, which is applied in the field of medical supplies to achieve the effects of long-term salt water resistance, long-term urine resistance, and excellent constant elongation and hardness

Inactive Publication Date: 2015-03-11
SUZHOU VIVOTIDE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem to be solved: Aiming at the defects of the existing artificial dura mater, the present invention provides a composite artificial dura mater and its preparation method, the artificial dura mater has Excellent 100% modulus, tear strength, biocompatibility and hemocompatibility, and can withstand salt water and urine for a long time

Method used

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  • Composite artificial endocranium and preparation method thereof

Examples

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Effect test

Embodiment 1

[0017] A composite artificial dura mater, comprising the following raw materials in parts by mass: vinyl silicone rubber: 50 parts; hydroxyl silicone oil: 2 parts; polyethylene glycol: 1 part; meteorological white carbon black: 40 parts; vulcanizing agent Bis-25: 0.7 parts; polylactic acid: 20 parts; tricalcium phosphate: 5 parts; chitosan: 2 parts; polytetrafluoroethylene: 1 part.

[0018] A preparation method of a composite artificial dura mater, comprising the steps of:

[0019] (1) Mix vinyl silicone rubber, hydroxyl silicone oil, polyethylene glycol, meteorological silica, vulcanizing agent bis-25, polylactic acid, tricalcium phosphate, chitosan and polytetrafluoroethylene at a temperature of 150 Place it at ℃ for 20min to obtain the mixed material;

[0020] (2) Place the mixed material in the oven for 6 hours, and set the oven temperature to 150°C to obtain the mixed rubber;

[0021] (3) Mix the mixed rubber and gasoline at a mass ratio of 1:3.5 to make a glue, and the...

Embodiment 2

[0023] A composite artificial dura mater, comprising the following raw materials in parts by mass: vinyl silicone rubber: 75 parts; hydroxyl silicone oil: 5 parts; polyethylene glycol: 4 parts; meteorological white carbon black: 60 parts; vulcanizing agent Bi-25: 1.7 parts; polylactic acid: 35 parts; tricalcium phosphate: 12 parts; chitosan: 6 parts; polytetrafluoroethylene: 4 parts.

[0024] A preparation method of a composite artificial dura mater, comprising the steps of:

[0025] (1) Mix vinyl silicone rubber, hydroxyl silicone oil, polyethylene glycol, meteorological silica, vulcanizing agent bis-25, polylactic acid, tricalcium phosphate, chitosan and polytetrafluoroethylene at a temperature of 160 Place it at ℃ for 30min to obtain the mixed material;

[0026] (2) Place the mixed material in the oven for 8 hours, and set the oven temperature to 200°C to obtain the mixed rubber;

[0027] (3) Mix the mixed rubber and gasoline at a mass ratio of 1:3.5 to make a glue, and t...

Embodiment 3

[0029] A composite artificial dura mater, comprising the following raw materials in parts by mass: vinyl silicone rubber: 58 parts; hydroxyl silicone oil: 2.5 parts; polyethylene glycol: 2 parts; meteorological white carbon black: 45 parts; vulcanizing agent Bi-25: 1 part; polylactic acid: 23 parts; tricalcium phosphate: 7 parts; chitosan: 3 parts; polytetrafluoroethylene: 2 parts.

[0030] A preparation method of a composite artificial dura mater, comprising the steps of:

[0031] (1) Mix vinyl silicone rubber, hydroxyl silicone oil, polyethylene glycol, meteorological silica, vulcanizing agent bis-25, polylactic acid, tricalcium phosphate, chitosan and polytetrafluoroethylene at a temperature of 150 Place it at ℃ for 20min to obtain the mixed material;

[0032] (2) Place the mixed material in the oven for 6 hours, and set the oven temperature to 150°C to obtain the mixed rubber;

[0033] (3) Mix the mixed rubber and gasoline at a mass ratio of 1:3.5 to make a glue, and the...

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Abstract

The invention provides a composite artificial endocranium and a preparation method thereof. The artificial endocranium is composed of the following raw materials in parts by weight: 50 to 75 parts of vinyl silicone rubber, 2 to 5 parts of hydroxy silicone oil, 1 to 4 parts of polyethylene glycol, 40 to 60 parts of fumed silica, 0.7 to 1.7 parts of 2,5-dimethyl-2,5-di(t-butylperoxy)hexane, 20 to 35 parts of polylactic acid, 5 to 12 parts of tricalcium phosphate, 2 to 6 parts of chitosan, and 1 to 4 parts of polytetrafluoroethylene. The provided artificial endocranium has an excellent 100% stress at definite elongation, tear strength, biocompatibility, and blood compatibility, and is capable of tolerating brine and urine for a long time.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to a composite artificial dura mater and a preparation method thereof. Background technique [0002] The artificial meninges provide a type I collagen scaffold for the dural defect, which is conducive to the growth of fibroblasts and the development of new dura mater tissue. It has good histocompatibility and degradability, and can effectively reduce the leakage of cerebrospinal fluid and intracranial infections, while also reducing the formation of scar tissue between brain or spinal cord tissue and adjacent tissues. [0003] At present, there are few artificial dura mater on the market, and its 100% modulus is poor, its tear strength is low, and it is not resistant to salt water, and its biocompatibility and blood compatibility are poor. Contents of the invention [0004] Technical issues solved: Aiming at the defects existing in the existing artificial dura mater, the present ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50
Inventor 潘林根邱东成刘乐峰
Owner SUZHOU VIVOTIDE BIOTECH
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