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Lipoic acid cyclopentane multi-hydrogen phenanthrene ester C and extraction method and pharmaceutical application thereof

A technology of lipoic acid cyclopentane and dohydrophenanthrene, which is applied in the direction of drug combination, pharmaceutical formula, steroids, etc., can solve the problems of kidney damage, heart depression, abnormal metabolism, etc., and achieve remarkable curative effect

Inactive Publication Date: 2015-03-11
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have certain side effects, such as cardiac depression, metabolic abnormalities, kidney damage, etc.

Method used

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  • Lipoic acid cyclopentane multi-hydrogen phenanthrene ester C and extraction method and pharmaceutical application thereof
  • Lipoic acid cyclopentane multi-hydrogen phenanthrene ester C and extraction method and pharmaceutical application thereof
  • Lipoic acid cyclopentane multi-hydrogen phenanthrene ester C and extraction method and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 1000g of ginseng, crush it, add yeast and appropriate amount of water, ferment for 12 hours, treat it under high temperature and high pressure for 8 hours, take it out, and dry it to obtain the product of ginseng yeast fermentation at high temperature and high pressure; extract the product of ginseng yeast fermentation at high temperature and high pressure with chloroform for 3 times, Add 5 L of chloroform each time, combine the chloroform extracts, and evaporate to dryness to obtain chloroform extracts; take the chloroform extracts, perform column chromatography with silica gel as the adsorbent, and use petroleum ether-dichloromethane (20:1~1:1) Carry out gradient elution, collect the part eluate of lipoic acid cyclopentane and polyhydrophenanthrene ester C, and recover the solvent to obtain the crude product of lipoic acid cyclopentane and polyhydrophenanthrene ester C, then perform silica gel column chromatography, and use petroleum ether- Acetone (10:1) was used...

Embodiment 2

[0047] Take 1000g of ginseng, crush it, add yeast and appropriate amount of water, ferment for 24 hours, treat it under high temperature and high pressure for 6 hours, take it out, and dry it to obtain the product of ginseng yeast fermentation at high temperature and high pressure; extract the product of ginseng yeast fermentation at high temperature and high pressure with chloroform for 3 times, Add 8 L of chloroform each time, combine the chloroform extracts, and evaporate to dryness to obtain chloroform extracts; take the chloroform extracts, perform column chromatography with silica gel as the adsorbent, and use petroleum ether-dichloromethane (20:1~1:1) Carry out gradient elution, collect the part eluate of lipoic acid cyclopentane and polyhydrophenanthrene ester C, and recover the solvent to obtain the crude product of lipoic acid cyclopentane and polyhydrophenanthrene ester C, then perform silica gel column chromatography, and use petroleum ether- Acetone (10:1) was used...

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Abstract

The invention relates to lipoic acid cyclopentane multi-hydrogen phenanthrene ester C and pharmaceutical application thereof. The lipoic acid cyclopentane multi-hydrogen phenanthrene ester C is prepared from the raw material Panax ginseng C.A.Mey. by a method including the steps of crushing, yeast fermentation, high temperature and high pressure treatment, drying, chloroform extraction, silica gel column chromatography and recrystallization; the chemical name of the lipoic acid cyclopentane multi-hydrogen phenanthrene ester C is (3S,10R,13R)-17-((2R,E)-5-ethyl-6-methylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 5-(1,2-dithiolan-3-yl)pentanoate]. The invention provides application of the lipoic acid cyclopentane multi-hydrogen phenanthrene ester C to preparation of a medicine for treating hypertension.

Description

technical field [0001] The invention relates to a lipoic acid cyclopentanedohydrophenanthrene ester C, its extraction method and its medicinal application. It belongs to new compounds and their medicinal uses. Background technique [0002] ginseng Panax giseng C.A.Mey. is a plant of the genus Panax genus Araliaceae. in, Panax The meaning of Greek is "panacea", and the Manchu pronunciation of ginseng is "Orhouda", which means "king of herbs". As a traditional medicinal material, it has a history of thousands of years and is widely used in countries all over the world. Ginseng greatly invigorates the vital energy, restores the veins and strengthens the spleen, nourishes the spleen and lungs, promotes fluid production, and calms the nerves. [0003] Hypertension is a clinical syndrome mainly manifested by increased systemic arterial pressure, and is the most common cardiovascular disease. The pathogenic factors of essential hypertension mainly have two categories, one i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J33/00C12P33/20A61P9/12
CPCA61K31/58C12P33/20C07J33/002
Inventor 赵岩张连学唐国胜郜玉钢许永华张爱华杨鹤雷锋杰刘双利
Owner JILIN AGRICULTURAL UNIV
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