Method for producing A ring degradation products through plant sterol fermentation

A technology for phytosterols and degradants, which is applied in the field of fermenting phytosterols to produce A-ring degradants, can solve the problems of difficulty in product accumulation, great environmental impact, and difficulty in extraction, and achieves the effects of improving yield and inhibiting degradation.
CN104404099AInactive Publication Date: 2015-03-11江西赣亮医药原料有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
江西赣亮医药原料有限公司
Publication Date
2015-03-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for producing A ring degradation products through plant sterol fermentation. The method comprises the following steps: (A) preparing a liquid inoculant containing mycobacterium fortuitum; (B) carrying out fermentation culture; (C) extracting and separating so as to obtain the A ring degradation products. The provided fermentation method for preparing A ring degradation products is carried out in an oil-free condition, thus the ring opening of A ring and B ring is effectively inhibited, thus the degradation is inhibited, the yield is increased, and the weight yield can reach 35 to 40%.
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Description

technical field

[0001] The invention relates to a method for preparing an important intermediate of steroid hormones, in particular to a method for fermenting phytosterols to produce A ring degradation products. Background technique

[0002] In modern times, the research results on the preparation of steroid intermediates from phytosterols using microbial methods have been widely reported and studied. The earliest related reports can be traced back to 1937. Mamoli and Vercellone published two patents Ber.70470 and Ber.702079 , discloses the reduction of 17-keto-steroids to 17-β-hydroxysteroids by yeast fermentation. Thereafter, Peterson and Murray disclosed in US Patent No. 2602769 a method of 11-a-hydroxylation of progesterone using Rhizopus fungus. In 1972, Kraychy et al disclosed in US Patent No. 3684657 the method of using Mycobacterium SP. NRRL B-3683 to degrade the 17-position aliphatic chain to prepare 4-AD, ADD. In 1973, Marsheck et al disclosed in U.S. Patent No. ...

Claims

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