Curcumin nanoparticles and preparation method thereof

Abstract

The invention discloses a curcumin nanoparticle preparation. Curcumin is taken as a raw material, linear-dendritic monomethoxypolyethylene glycol-polycaprolactone is taken as a medicament carrier, and the curcumin nanoparticle preparation comprises the following components in parts by weight: 1 part of curcumin and 5-10 parts of linear-dendritic monomethoxypolyethylene glycol-polycaprolactone. A preparation method comprises the following steps: dissolving curcumin and linear-dendritic monomethoxypolyethylene glycol-polycaprolactone in an organic solvent, performing rotary evaporation to remove the organic solvent after full dissolution to obtain a medicament-containing thin film, adding into a water phase, performing hydratation at 50-80 DEG C to obtain a nanoparticle solution, and filtering by a microporous filter membrane to obtain the curcumin nanoparticle preparation. The nanoparticle preparation disclosed by the invention can ensure that the nanoparticle preparation is less prone to being swallowed by a reticuloendothelial system in vivo, can realize a slow-release effect and is conductive to clinical application.

Description

technical field [0001] The invention relates to a curcumin nanoparticle whose carrier is line-dendrimer monomethoxy polyethylene glycol-polycaprolactone and a preparation method thereof. Background technique [0002] Curcumin (Curcumin) is a polyphenolic compound extracted from turmeric, curcuma, turmeric, etc. [0003] [0004] It has various pharmacological activities such as anti-inflammation, anti-oxidation, anti-tumor, hypolipidemic, antibacterial, etc. The oral dose can reach 8 grams per day without any side effects. It is particularly pointed out that in terms of anti-tumor activity, curcumin can act on tumor cells through various channels such as cells, proteins, genes, and signal transduction pathways, affecting the occurrence and development stages of tumors (initiation, promotion, and evolution, etc.), and can By inhibiting angiogenesis to achieve the purpose of anti-tumor invasion and metastasis. The multi-target anticancer activity of curcumin has become a ...

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Problems solved by technology

[0008] As far as the current carrier research of curcumin is concerned, the carriers studied include linear and star-shaped monomethoxypolyethylene glycol-polycaprolactone, and linear-dendritic monomethoxypolyethylene glycol-polycaprolactone. Not yet reported

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