Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of dasatinib tablet and its preparation process

A technology for dasatinib and nigra tablets, which is applied in the field of pharmaceutical preparations, can solve the problems of large differences in tablet dissolution uniformity, affecting drug absorption and metabolism, and hidden dangers of drug use by patients, achieving rapid drug dissolution, improving drug use, The effect of eliminating drug adhesion

Active Publication Date: 2018-07-06
SHANDONG NEWTIME PHARMA
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of new excipients can not only change the appearance of the pharmaceutical preparation, but also improve the dissolution rate. In the prior art, a fast-dissolution and stable dasatinib tablet has not been provided, and sticking is prone to occur during the drug release process. phenomenon, resulting in a large difference in dissolution uniformity between different tablets, and if the drug with adhesion is taken, the dissolution difference between the tablets is obvious, which affects drug absorption and metabolism, and brings great hidden dangers to patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of dasatinib tablet and its preparation process
  • A kind of dasatinib tablet and its preparation process
  • A kind of dasatinib tablet and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Preparation Process:

[0027] (1) Dasatinib, calcium sulfate, and calcium carbonate were passed through a 100-mesh sieve, weighed the prescription amount, mixed evenly with silicon dioxide, added an appropriate amount of water, granulated, dried at 50°C, and granulated through a 18-mesh sieve;

[0028] (2) Mix the sieved granules with magnesium stearate evenly, and press into tablets.

Embodiment 2

[0030]

[0031] Preparation Process:

[0032] (1) Pass dasatinib and calcium hydrogen phosphate through a 100-mesh sieve, weigh the prescription amount, mix it with silicon dioxide evenly, add an appropriate amount of water, granulate, dry at 60°C, and granulate through a 18-mesh sieve;

[0033] (2) Mix the sieved granules with talcum powder and sodium stearyl fumarate evenly, and press into tablets.

Embodiment 3

[0035]

[0036] Preparation Process:

[0037] (1) Pass dasatinib and calcium sulfate through a 100-mesh sieve, weigh the prescription amount, mix with silicon dioxide evenly, add an appropriate amount of water, granulate, dry at 60°C, and granulate with a 18-mesh sieve;

[0038] (2) Mix the sieved granules with magnesium stearate evenly, and press into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of preparations, and in particular relates to a dasatinib tablet and a preparation process thereof. The tablet of the invention consists of dasatinib, silicon dioxide, a filler and a lubricant. The technical solution of the present invention greatly improves the dissolution uniformity of dasatinib, and disintegrates rapidly, ensuring the rapid dissolution of the drug in the body fluid of the gastrointestinal tract, and no adhesion phenomenon occurs during the drug release process, which improves the safety of the drug. It eliminates the hidden dangers brought by the adhesion and the large difference in drug uniformity to patients. On the other hand, the preparation process of the present invention is simple and suitable for mass production requirements.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a dasatinib tablet and a preparation process thereof. Background technique [0002] Dasatinib (Dasatinib / Sprycel), molecular formula C 22 h 26 C l N 7 o 2 S.H 2 O, molecular weight 506.02, used for all disease stages of chronic myelogenous leukemia (chronic phase, accelerated phase, lymphoid cell blast phase and myeloid blast phase) in adult patients. Among the approved drugs, Sprycel is the first oral chemotherapy drug capable of inhibiting multiple configurations of tyrosine protein kinase Abl. At nanomolar concentration, the drug can inhibit Bcr-Abl, SRC kinase family (SRC, LCK, YES, FYN), c-KIT, EPHA2 and PDGFR-B and other kinases. By inhibiting the action of the aforementioned kinases, Sprycel inhibits the proliferation of leukemia cells in the bone marrow of CML and Ph+ALL. It has the advantages of long-lasting curative effect and high safety,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/506A61K47/04A61K47/02A61P35/02
Inventor 赵志全郝贵周吴善霞高西蒙
Owner SHANDONG NEWTIME PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com