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Glipizide composition freeze-dried tablet and preparation method thereof

A technology of glipizide and composition, applied in the field of glipizide composition freeze-dried tablet and preparation thereof, to achieve the effects of improving bioavailability, improving formability and large dissolution rate

Inactive Publication Date: 2015-03-25
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of glipizide freeze-dried tablets by freeze-drying process

Method used

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  • Glipizide composition freeze-dried tablet and preparation method thereof
  • Glipizide composition freeze-dried tablet and preparation method thereof
  • Glipizide composition freeze-dried tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028]

[0029] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.

[0030] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0031] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0032] D. Weigh 2.5 g of glipizide, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.

[0033] E. After measuring the content of glipizide in the medicinal solution,...

Embodiment 2

[0036]

[0037] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.

[0038] B. Measure 45ml of purified water, boil it, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0039] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0040] D. Weigh 2.5 grams of glipizide (calculated as 1000 tablets), add 1L of corn-sucrose solution, and stir for 30 minutes.

[0041] E. After measuring the content of glipizide i...

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Abstract

The invention provides a glipizide composition freeze-dried tablet and a preparation method thereof, and relates to the technical field of medicine production. The glipizide composition freeze-dried tablet consists of glipizide, starch and sucrose, wherein the starch and the sucrose are used as accessories; the normal corn starch is subjected to heating process treatment, so that the bonding and disintegration effects of the starch in the tablet are enhanced, and the formability of the tablet is improved; only two accessories, namely the starch and the sucrose, are required by the glipizide composition freeze-dried tablet. By virtue of a twice-heating and twice-cooling freeze-drying process, the glipizide composition freeze-dried tablet has better formability due to the process of cooling twice and heating twice, and the dissolution rate of the tablet is improved, so that the bioavailability of the tablet is improved; the tablet is capable of overcoming the shortcomings of a normal glipizide tablet and reducing the variety and dosage of accessories in the glipizide tablet; and the tablet is high in dissolution rate and bioavailability, so that the curative effect and safety of clinical medication are guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a freeze-dried tablet of a glipizide composition and a preparation method thereof. Background technique [0002] Glipizide is mainly used for mild and moderate non-insulin-dependent patients who have failed to achieve good results with diet control alone; although insulin was used in the past, the daily requirement was below 30-40 units; for asymptomatic patients The patient still had significant hyperglycemia on the basis of diet control. [0003] Structural formula: [0004] [0005] Molecular weight: 445.54 [0006] Ordinary glipizide tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. According to the second part of the Chinese Pharmacopoeia (2010 edition), The quality standard of Glipizide Tablets is qualified when the dissolution rate of Glipizide Tab...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/64A61K47/36A61K47/26A61P3/10
Inventor 葛奎郝结兵吴函峰汪志琼汪宁卿
Owner HAINAN WEI KANG PHARMA QIANSHAN
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