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Collagen polypeptide skin photo-damage repairing film and preparation method thereof

A technology of collagen polypeptide and photodamage, which is applied in the field of biomedical materials, can solve problems such as skin photodamage, and achieve the effect of increasing diversity

Inactive Publication Date: 2015-04-08
SICHUAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The purpose of the present invention is to provide a new collagen polypeptide skin photodamage repair film, which can promote skin repair through the release of collagen polypeptides and plant polysaccharides, so as to solve the current problem of skin photodamage. The collagen polypeptide photodamage of the present invention The repair film has good biocompatibility and air permeability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In a clean and dry beaker, add 0.1 part of collagen polypeptide, 0.1 part of soluble starch, 0.1 part of ganoderma lucidum polysaccharide, 0.3 part of lentinan, 0.1 part of wolfberry polysaccharide and 2 parts of deionized water, stir well to dissolve; Add 1 part of sodium carboxymethylcellulose and 9 parts of deionized water into a beaker and mix them evenly in a constant temperature water bath at 40°C to form a transparent jelly, then add 2 parts of glutaraldehyde and 2.5 parts of glycerin, and stir Mix it well.

[0036] Pour the mixed solution in the first beaker into the second beaker, continue mechanical stirring, stir to make it mix evenly, and obtain a viscous substance.

[0037] Evenly spread the jelly on the dry and clean template to form a jelly layer with uniform thickness and smooth surface, dry it in a constant temperature oven at 60°C, and peel off the film to obtain the collagen polypeptide skin photodamage repair film.

Embodiment 2

[0039] In a clean and dry beaker, add 0.1 part of collagen polypeptide, 0.1 part of soluble starch, 0.3 part of ganoderma lucidum polysaccharide, 0.5 part of lentinan, 0.1 part of wolfberry polysaccharide and 2 parts of deionized water, stir well to dissolve. Add 1 part of sodium carboxymethyl cellulose and 9 parts of deionized water to the second beaker, stir evenly in a constant temperature water bath at 40°C to form a transparent jelly, then add 2 parts of glutaraldehyde and 2.5 parts of glycerin Alcohol, stir to combine evenly.

[0040] Pour the mixed solution in the first beaker into the second beaker, and continue mechanical stirring until a uniform viscous jelly is obtained.

[0041] Evenly spread the jelly on the dry and clean template to form a jelly layer with uniform thickness and smooth surface, dry it in a constant temperature oven at 60°C, and peel off the film to obtain the collagen polypeptide skin photodamage repair film.

Embodiment 3

[0043] In a clean and dry beaker, add 0.1 part of collagen polypeptide, 0.1 part of soluble starch, 0.5 part of ganoderma lucidum polysaccharide, 0.1 part of lentinan, 0.1 part of wolfberry polysaccharide and 2 parts of deionized water, stir well to dissolve. Add 1 part of sodium carboxymethyl cellulose and 9 parts of deionized water to the second beaker, stir evenly in a constant temperature water bath at 40°C to form a transparent jelly, then add 2 parts of glutaraldehyde and 2.5 parts of glycerin Alcohol, stir to combine evenly.

[0044] Pour the mixed solution in the first beaker into the second beaker, and continue mechanical stirring until a uniform viscous jelly is obtained.

[0045] Evenly spread the jelly on the dry and clean template to form a jelly layer with uniform thickness and smooth surface, dry it in a constant temperature oven at 60°C, and peel off the film to obtain the collagen polypeptide skin photodamage repair film.

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PUM

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Abstract

The invention relates to a preparation method of a collagen polypeptide skin photo-damage repairing film, and belongs to the field of biomedical materials. According to the collagen polypeptide skin photo-damage repairing film disclosed by the invention, the basic framework structure of the film is formed by collagen polypeptide, sodium carboxymethylcellulose, glutaraldehyde and starch, glycerol is added as a moisturizer to control the moisture of the film, and antioxidants of ganoderma lucidum polysaccharides, mushroom polysaccharides, lycium barbarum polysaccharides and the like are added; finally the uniformly mixed pasty mixed solution is poured in a die and formed, and dried in an oven at a constant temperature; and the collagen polypeptide skin photo-damage repairing film with good biocompatibility and oxidation resistance is obtained after being uncovered.

Description

technical field [0001] The invention relates to a collagen polypeptide skin photodamage repair film and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] With the increasing air pollution, the destruction of the ozone layer leads to the increase of ultraviolet (ultraviolet, UV) radiation on the surface, which has various adverse effects on the human body. Such as skin photoaging, skin cancer, corneal photodamage and lens opacity. In the natural environment, UV accounts for about 13% of sunlight. When reaching the surface of the earth, most of the medium-wave ultraviolet rays (ultraviolet B, UVB) and almost all of the short-wave ultraviolet rays (ultraviolet C, UVC) are absorbed by the ozone layer in the atmospheric stratosphere. Therefore, the long-wave ultraviolet rays (ultraviolet A, UVA) in nature ) accounted for about 97%, and UVB only accounted for 3%. However, because the biological activity of UVA is much we...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K38/39A61P17/16A61P17/18A61K31/715
Inventor 舒子斌丁胜利杨华代雪梅
Owner SICHUAN NORMAL UNIVERSITY
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