Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of material for promoting fistula repair and its preparation method

A technology for repairing materials and fistulas, which is applied in medical science, surgery, etc. It can solve the problems of rough surface of drainage materials, increase pain of patients, and complicated treatment process, and achieve low recurrence rate, promotion of healing, and low infection rate.

Inactive Publication Date: 2016-11-09
SILK PLUG BEIJING BIOMEDICINE TECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drainage materials commonly used in the treatment of anal fistula include rubber strips, gauze strips, and rubber tubes. These drainage materials have rough surfaces or hard materials, and they need to be repeatedly inserted into the patient's body, which often increases pain and inconvenience for the patient. The application of these drainage materials requires secondary surgery to remove; then inject fibrin glue, and close the fistula at both ends with catgut suture, making the treatment process more complicated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of material for promoting fistula repair and its preparation method
  • A kind of material for promoting fistula repair and its preparation method
  • A kind of material for promoting fistula repair and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The invention provides a fistula-promoting repair material, which includes an adventitia. In the present invention, the thickness of the outer membrane is preferably 0.03 mm to 0.1 mm, preferably 0.05 mm to 0.09 mm. In the present invention, the preparation method of the outer membrane preferably includes the following steps:

[0047] The silk protein solution is first concentrated and then mixed with glycerol to obtain a silk protein outer membrane solution;

[0048] The silk protein outer membrane solution is injection molded, and the outer membrane is obtained after drying.

[0049] In the present invention, the silk protein solution is first concentrated and then mixed with glycerol to obtain the silk protein outer membrane solution. In the present invention, the silk protein solution is preferably degummed, dissolved and dialyzed sequentially to obtain a silk protein solution. In the present invention, there is no special limitation on the source of the silk, an...

Embodiment 1

[0078] Put 150g of silk into 6L of 0.05% sodium carbonate aqueous solution and boil for 30min, wash 7 times after the end, repeat the treatment 3 times, remove all the sericin around the silk, and obtain pure degummed silk fibroin after drying;

[0079] Weigh 10g degummed silk fibroin and dissolve in 100mL ternary solution (CaCl 2 / water / ethanol molar ratio is 1:8:2), and then soaked in deionized water with a dialysis bag with a molecular weight cut-off of 3500 for dialysis for 3 days, during which the water was changed every two hours. Centrifuge twice for 20 minutes to obtain a silk protein solution with a mass fraction of 6%; then place the solution in a glass mold at 60°C in an oven and slowly concentrate for 3 days to make the mass fraction reach 20%, and pour the concentrated solution into a beaker , add glycerin with a mass ratio of 20% to it, and stir with a magnetic stirrer to mix evenly to obtain a silk protein outer membrane solution;

[0080] Clamp and dip the abo...

Embodiment 2

[0090] Put 150g of silk into 6L of 0.05% sodium carbonate aqueous solution and boil for 30 minutes, wash 6 times after finishing, repeat the treatment 3 times, remove all the sericin around the silk, and obtain pure degummed silk fibroin after drying;

[0091] Dissolve 15g of degummed silk fibroin in 100mL LiBr solution with a concentration of 9.3mol / L, and dissolve it at 60°C for 4 hours, then use a dialysis bag with a molecular weight cut-off of 3500 to soak in deionized water for dialysis for 3 days, and change it every two hours during the period water, remove LiBr in the solution, centrifuge the dialyzed solution at 9000 rpm for 20 min twice, to obtain a 6% silk protein solution;

[0092] Put the above silk fibroin solution in a glass mold and slowly concentrate in an oven at 60°C for 3 days to make the mass fraction reach 30%. Pour the concentrated solution into a beaker, add glycerin with a mass ratio of 40% to it, and stir with a magnetic stirrer , so that it is mixed ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention provides a fistula restoration promoting material and a preparation method thereof. The fistula restoration promoting material comprises an inner core and an outer film covering the surface of the inner core; the fistula restoration promoting material is cylindrical or circular-platform-shaped; the inner core comprises fibroin and has a sponge structure; the outer film comprises fibroin and glycerol. The restoration material is cylindrical or circular-platform-shaped and is similar with the shape of a fistula, so that the restoration material can be easily put into a fistula and can be planted into the fistula in one step; the outer film comprises the fibroin and the glycerol, has good biocompatibility and biodegradability, can be absorbed and degraded by cells of human bodies, and does not need to be taken out by secondary operation; the outer film has the drainage effect; the inner core comprises the fibroin, has the sponge structure, is used as a biological bracket and has the restoration effect, so that the restoration material has the restoration effect and is convenient to use. The restoration material can induce tissue regeneration and reshaping and promote anal fistula to be healed; the fistula restoration promoting material has good mechanical property and higher porosity; by the aid of the restoration material, the recurrence rate is low and the inflammation infection rate is low.

Description

technical field [0001] The invention belongs to the technical field of fistula repair materials, and in particular relates to a fistula-promoting repair material and a preparation method thereof. Background technique [0002] Anal fistula, also known as "anorectal fistula", is generally composed of three parts: primary internal opening, fistula tract and secondary external opening. It is one of the common multiple diseases in the field of anorectal surgery. Most scholars believe that the vast majority of anal fistulas are secondary to the anorectal abscess caused by the general purulent infection of the anal gland, and the abscess will not heal after rupture and form a fistula; a few are caused by specific infections, such as tuberculosis, Crohn's disease, etc. disease, extraintestinal manifestations of ulcerative colitis, etc. Clinically, the common symptoms of anal fistula are swelling, pain and discharge of pus in the anus. Due to the influence of the internal opening a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/00A61L31/14A61B17/00
Inventor 吴昊吕强林莎莎
Owner SILK PLUG BEIJING BIOMEDICINE TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com