Preparation method of ultrasound and magnetic resonance two-mode contrast medium having lymph targeting
A lymphatic targeting and magnetic resonance technology, which can be used in nuclear magnetic resonance/magnetic resonance imaging contrast agents, echo/ultrasound imaging agents, and preparations for in vivo tests, etc. Improve diagnostic accuracy and efficiency, good stability and easy metabolism
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[0035] Example 1
[0036] a. Add 20 parts by mass of surfactant to 10 parts of alkaline solution, stir at 30 ° C for 5 minutes, after the surfactant is completely dissolved, add 100 parts of silicon source to the solution, continue After stirring for 5 minutes at 30°C, 10 parts of the magnetic compound were added, followed by the formation of a sol mixture, followed by stirring at 30°C for 6 hours, washing with alcohol and deionized water at 5000 rpm, and then drying in an oven at 60°C Dry for 20 hours to obtain a powdery product;
[0037] b. After calcining the powder obtained in the above a at 500° C. for 4 hours, the powdery nano-mesoporous silica particles with the surfactant removed are obtained;
[0038] c. Disperse 50 parts by mass of the nanoparticles obtained in the above b in 500 parts of organic solvent, add 10 parts of silane coupling agent, stir at 30 ° C for 6 hours, wash with ethanol three times and then use up Washed with ionized water twice, and centrifuged ...
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[0041] Example 2
[0042] a. Add 25 parts by mass of surfactant to 15 parts of alkaline solution, stir at 30°C for 8 minutes, after the surfactant is completely dissolved, add 150 parts of silicon source to the solution, continue After stirring for 10 minutes at 30°C, 10 parts of the magnetic compound were added, followed by the formation of a sol mixture, followed by stirring at 40°C for 7 hours, washing with alcohol and deionized water at 6500 rpm, followed by drying in an oven at 65°C Dry for 24 hours to obtain a powdery product;
[0043] b. After calcining the powder obtained in the above a at 550° C. for 6 hours, the powdery nano-mesoporous silica particles with the surfactant removed are obtained;
[0044] c. Disperse 60 parts by mass of the nanoparticles obtained in the above b in 700 parts of organic solvent, add 20 parts of silane coupling agent, stir at 30 ° C for 7 hours, wash with ethanol three times and then use up Washed twice with ionized water, centrifuged at...
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[0047] Example 3
[0048] a. Add 25 parts by mass of surfactant to 20 parts of alkaline solution, stir at 40°C for 10 minutes, after the surfactant is completely dissolved, add 200 parts of silicon source to the solution, continue After stirring at 40°C for 15 minutes, 20 parts of the magnetic compound were added, followed by a sol mixture, which was then stirred at 40°C for 6 hours, washed with alcohol and deionized water at 6000 rpm, and then dried in an oven at 80°C Dry for 20 hours to obtain a powdery product;
[0049] b. After calcining the powder obtained in the above a at 550° C. for 6 hours, the powdery nano-mesoporous silica particles with the surfactant removed are obtained;
[0050] c. Disperse 100 parts by mass of nanoparticles obtained in the above b in 500 parts of organic solvent, add 20 parts of silane coupling agent, stir at 30°C for 6 hours, wash with ethanol three times and then use up Washed twice with ionized water, centrifuged at 6000 rpm, and then drie...
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