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Preparation method of ultrasound and magnetic resonance two-mode contrast medium having lymph targeting

A lymphatic targeting and magnetic resonance technology, which can be used in nuclear magnetic resonance/magnetic resonance imaging contrast agents, echo/ultrasound imaging agents, and preparations for in vivo tests, etc. Improve diagnostic accuracy and efficiency, good stability and easy metabolism

Inactive Publication Date: 2015-04-22
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in recent years, single-function contrast agents have been unable to meet the diverse needs of medicine. Therefore, dual-mode contrast agents can achieve complementary advantages in imaging and have attracted much attention.

Method used

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  • Preparation method of ultrasound and magnetic resonance two-mode contrast medium having lymph targeting
  • Preparation method of ultrasound and magnetic resonance two-mode contrast medium having lymph targeting
  • Preparation method of ultrasound and magnetic resonance two-mode contrast medium having lymph targeting

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] a. Add 20 parts by mass of surfactant to 10 parts of alkaline solution, stir at 30°C for 5 minutes, after the surfactant is completely dissolved, add 100 parts of silicon source into the solution, continue After stirring at 30°C for 5 minutes, 10 parts of magnetic compounds were added, followed by the formation of a sol mixture, followed by stirring at 30°C for 6 hours, washing with ethanol and deionized water at 5000 rpm, and then drying in an oven at 60°C. Dry for 20 hours to obtain powdery product;

[0037] b. After the powder obtained in above a is roasted at 500° C. for 4 hours, the powdered nanometer mesoporous silica particles from which the surfactant is removed are obtained;

[0038] c. Disperse 50 parts by mass of nanoparticles obtained in b above in 500 parts of organic solvent, add 10 parts of silane coupling agent, stir at 30°C for 6 hours, wash with ethanol three times and use Washed twice with deionized water, and centrifuged at 6000 rpm, then dried in a...

Embodiment 2

[0042] a. Add 25 parts by mass of surfactant to 15 parts of alkaline solution and stir at 30°C for 8 minutes. After the surfactant is completely dissolved, add 150 parts of silicon source into the solution and continue After stirring at 30°C for 10 minutes, 10 parts of magnetic compounds were added, and then a sol mixture was generated, followed by stirring at 40°C for 7 hours, washing with alcohol and deionized water at 6500 rpm, and then drying in an oven at 65°C. Dry for 24 hours to obtain powdery product;

[0043] b. After the powder obtained in above a is roasted at 550° C. for 6 hours, powdery nanometer mesoporous silica particles from which the surfactant has been removed are obtained;

[0044] c. Disperse 60 parts by mass of nanoparticles obtained in b above in 700 parts of organic solvent, add 20 parts of silane coupling agent, stir at 30°C for 7 hours, wash with ethanol three times and use Washed twice with deionized water, and centrifuged at 6500 rpm, then dried in...

Embodiment 3

[0048] a. Add 25 parts by mass of surfactant to 20 parts of alkaline solution, stir at 40°C for 10 minutes, after the surfactant is completely dissolved, add 200 parts of silicon source to the solution, continue After stirring at 40°C for 15 minutes, 20 parts of magnetic compounds were added, and then a sol mixture was generated, followed by stirring at 40°C for 6 hours, washing with alcohol and deionized water at 6000 rpm, and then drying in an oven at 80°C. Dry for 20 hours to obtain powdery product;

[0049] b. After the powder obtained in above a is roasted at 550° C. for 6 hours, powdery nanometer mesoporous silica particles from which the surfactant has been removed are obtained;

[0050] c. Disperse 100 parts by mass of nanoparticles obtained in b above in 500 parts of organic solvent, add 20 parts of silane coupling agent, stir at 30°C for 6 hours, wash with ethanol three times and use Washed twice with deionized water, and centrifuged at 6000 rpm, then dried in an ov...

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Abstract

The invention discloses a preparation method of an ultrasound and magnetic resonance two-mode contrast medium having lymph targeting. The preparation method comprises the following steps: adding a surfactant to an alkaline solution, stirring, adding a silicon source to the solution after the surfactant is dissolved completely, continuously stirring, adding a magnetic compound to generate a sol mixture, stirring, washing and carrying out centrifugal drying to obtain a powdery product; carrying out high-temperature calcination on the product to obtain powdery nanometer mesoporous silica particles without the surfactant; dispersing the particles in an organic solvent, adding a silane coupling agent, stirring, washing with ethyl alcohol and water, and carrying out centrifugal drying to obtain a powdery product; dispersing the powder in deionized water, adding a cross-linking agent and sodium hyaluronate, stirring, washing with water and carrying out centrifugal drying to obtain nano-particles; and dispersing the particles in deionized water, dropwise adding fluorocarbon, stirring, washing with water and drying to obtain the contrast medium. By utilizing the preparation method, integration of double imaging modes can be realized, and two imaging manners can be developed.

Description

technical field [0001] The invention relates to the field of preparation of nanomaterials, in particular to a preparation method of a dual-mode ultrasound and magnetic resonance contrast agent with lymphatic targeting. Background technique [0002] With the development of medical engineering and computer technology, medical imaging provides medical images of various modalities for clinical diagnosis. Medical images of different modalities can provide different information about relevant organs and tissues of the human body. Ultrasound imaging can coherently and dynamically observe the movement and function of organs; it can track lesions without being limited by its imaging layers. However, the resolution and definition of ultrasound diagnosis itself are low, gas has a great influence on ultrasound, and patients are easily affected by various factors such as intestinal gas interference, and the overall spatial position cannot be displayed in the same image. Magnetic resona...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K49/12A61K49/08
Inventor 何丹农刘恬姚燕杰柳真晶朱东晨朱君金彩虹
Owner SHANGHAI JIAO TONG UNIV
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