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Purification method for beta-phenylethyl alcohol prepared by bio-fermentation

The technology of a biological fermentation method and a purification method is applied in the field of purification of β-phenethyl alcohol, and can solve the problems of a purification method without natural flavor β-phenethyl alcohol and the like

Inactive Publication Date: 2015-04-22
SHANGHAI RES INST OF CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, there is no purification method about the natural fragrance β-phenylethanol prepared by biological fermentation method in the prior art

Method used

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  • Purification method for beta-phenylethyl alcohol prepared by bio-fermentation
  • Purification method for beta-phenylethyl alcohol prepared by bio-fermentation
  • Purification method for beta-phenylethyl alcohol prepared by bio-fermentation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Such as figure 1 As shown, the crude product containing 85wt% β-phenylethanol prepared by the biological fermentation method is placed in the raw material tank 1, and is transported by the booster pump 2 and filtered through the ultrafiltration membrane module 3. Polysulfone membrane, feed liquid inlet pressure is 3×10 5 Pa, the outlet pressure is 0.6×10 5 Pa, collect permeate.

[0026] The permeate is added to the still of the rectification tower a4, and the intermittent rectification method is adopted. The entire operating system is connected to the vacuum system through the vacuum system pipe 6 to perform vacuum precision rectification. The rectification tower a4 is filled with high-efficiency wire mesh structured packing, the packing height is 5m, and the rectification tower a4 is operated under an absolute pressure of 10mmHg. In the rectifying process, at first with reflux ratio be 4: 1 to collect the low-boiling impurity of tower top, then collect the beta-phen...

Embodiment 2

[0028] Such as image 3 As shown, the crude product containing 90wt% β-phenylethanol prepared by the biological fermentation method is uniformly placed in the raw material tank 1, and is transported into the ultrafiltration membrane module 3 by the booster pump 2 to filter, and the ultrafiltration membrane module 3 selects a molecular weight cut-off of 10KD ceramic membrane, feed liquid inlet pressure is 3×10 5 Pa, the outlet pressure is 0.3×10 5 Pa, collect permeate.

[0029] The permeate is added to the middle part of the rectification tower a4, and the whole operating system is connected to the vacuum system through the vacuum system pipe 6 to perform vacuum precision rectification operation. The rectification tower 4 is filled with high-efficiency random packing, the height of the packing is 2m, and the rectification tower a4 is operated under an absolute pressure of 5mmHg. during distillation. The top of the tower continuously collects low-boiling impurities with a re...

Embodiment 3

[0031] A method for purifying β-phenylethanol prepared by a biological fermentation method, comprising the following steps:

[0032] 1) Pretreatment of the crude product of β-phenylethanol: use the crude product of β-phenylethanol prepared by biological fermentation as raw material, remove residual macromolecular impurities in the β-phenylethanol through an ultrafiltration device, and collect the permeate; The ultrafiltration membrane used in the ultrafiltration device is a flat membrane with a molecular weight cut-off of 1000; the material of the ultrafiltration membrane is a polysulfone organic membrane material.

[0033] 2) Vacuum precision rectification purification: the permeate is added to a precision rectification tower, and the low-boiling point impurities and high-boiling point impurities are respectively removed through vacuum precision rectification to finally obtain a β-phenylethanol product with a purity higher than 99.9%.

[0034] The operating pressure of the pr...

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Abstract

The invention relates to a purification method for beta-phenylethyl alcohol prepared by bio-fermentation. The method comprises the steps of: 1) pretreatment of a beta-phenylethyl alcohol crude product: taking the beta-phenylethyl alcohol crude product prepared by bio-fermentation as the raw material, removing macromolecular impurities remaining in beta-phenylethyl alcohol through an ultrafiltration device, and collecting permeate liquid; and 2) vacuum precise rectification purification: adding the permeate liquid into a precise rectification tower, conducting vacuum precise rectification to remove low-boiling point impurities and high-boiling point impurities respectively, thus finally obtaining the beta-phenylethyl alcohol product with purity higher than 99.9%. Compared with the prior art, the method provided by the invention adopts the way of filtering the crude product by an ultrafiltration assembly and then performing rectification, is especially suitable for purification of the beta-phenylethyl alcohol product prepared by bio-fermentation, and the obtained product has high purity, which reaches more than 99.9%.

Description

technical field [0001] The invention relates to a method for purifying beta-phenylethanol, in particular to a method for purifying beta-phenylethanol prepared by a biological fermentation method. Background technique [0002] β-Phenylethyl alcohol is an aromatic alcohol with a fresh, elegant and delicate rose smell, and is widely used in detergents, cosmetics and other daily chemical fields and food applications. Beta-phenylethanol is formed naturally by yeast during fermentation, in addition to chemical synthesis on an industrial scale. During the fermentation process, most yeasts can produce fusel oil, and β-phenylethanol is an important component of fusel oil and a key factor in determining the quality of fermented food. For example, the concentration of β-phenylethanol in sake is 20 ~70mg / L, higher than 100mg / L in rice wine. Yeast cells can either synthesize it de novo or convert L-phenylalanine to β-phenylethanol through the amino acid catabolic pathway. With the imp...

Claims

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Application Information

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IPC IPC(8): C07C29/80C07C29/76C07C33/22
CPCC07C29/76C07C33/22
Inventor 许保云翟金国艾波李良君张丽雅吴高胜江孝平包春凤束世平荣绍丰
Owner SHANGHAI RES INST OF CHEM IND
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