Method for improving hydrophilicity and flexibility of polypeptide film by poly lactic acid-glycolic acid and waterborne polyurethane

A technology of polylactic acid glycolic acid and water-based polyurethane, applied in the field of polymer film preparation, to achieve the effect of easy mastery and simple operation

Inactive Publication Date: 2015-04-29
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the hydrophilicity and flexibility of the polypeptide film by using poly(lactic-co-glycolic acid) and water-based polyurethane.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Synthesis of Polypeptide-poly(lactic-co-glycolic acid) block copolymer

[0020] 16.1 g of poly(r-benzyl-L-glutamate) (molecular weight 80,000) and 7 g of carboxy-terminated poly(lactic-co-glycolic acid monolauryl ether) (molecular weight 3,000) were added to the dry reactor, Add 302 ml dimethyl sulfoxide followed by 0.048 g N,N' -Dicyclohexylcarbodiimide, stirred and reacted at 25°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0021] 2) Synthesis of water-based polyurethane

[0022] Add 5.71 grams of 2,4-toluene diisocyanate and 15 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 310 ml of dimethyl sulfoxide to dissolve, and add di Dibutyltin laurate, under an inert atmosphere, stir and react at 40°C for 40 minutes, add 0.4 g of dimethylol propionic acid for 15 minutes, add 0.97 g of 1,4-butanediol for 10 minutes, then add 1.22 g of ...

Embodiment 2

[0029] 1) Synthesis of Polypeptide-poly(lactic-co-glycolic acid) block copolymer

[0030] Add 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight: 85,000) and 7 g of carboxy-terminated poly(lactic-co-glycolic acid monolauryl ether) (molecular weight: 3,500) into the dry reactor, add 305 ml of dimethyl sulfoxide, then add 0.031 g of N,N'-diisopropylcarbodiimide, under an inert atmosphere, stir the reaction at 27°C for 4 days, terminate the reaction, filter, dialyze, and dry to obtain the target thing;

[0031] 2) Synthesis of water-based polyurethane

[0032] Add 5.71 grams of 2,4-toluene diisocyanate and 15.1 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 312 ml of dimethyl sulfoxide to dissolve, and add di Dibutyltin laurate, under an inert atmosphere, stir and react at 45°C for 50 minutes, add 0.4 g of dimethylolpropionic acid for 17 minutes, add 0.97 g of 1,4-butanediol for 12 minutes, then add 1.21 g of butanediol Alcohol ...

Embodiment 3

[0039] 1) Synthesis of Polypeptide-poly(lactic-co-glycolic acid) block copolymer

[0040]Add 16.5 g of poly(r-methyl-L-glutamate) (molecular weight: 90,000) and 7 g of carboxy-terminated poly(lactic-co-glycolic acid monolauryl ether) (molecular weight: 4,000) into the dry reactor, add 310 ml dimethyl sulfoxide, then add 0.046 g 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under inert atmosphere, stir and react at 30°C for 3 days, terminate the reaction, filter through , dialysis, and drying to obtain the target object;

[0041] 2) Synthesis of water-based polyurethane

[0042] Add 5.71 grams of 2,4-toluene diisocyanate and 15.1 grams of polytetrahydrofuran ether glycol (molecular weight: 1000) into the dry reactor, add 314 ml of dimethyl sulfoxide to dissolve, and add di Dibutyltin laurate, under an inert atmosphere, stir and react at 50°C for 60 minutes, add 0.4 g of dimethylolpropionic acid for 20 minutes, add 0.96 g of 1,4-butanediol for 15 minutes, and then add 1.23 g...

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Abstract

The invention discloses a method for improving hydrophilicity and flexibility of a polypeptide film by poly lactic acid-glycolic acid and waterborne polyurethane. The method comprises the following steps: 1) adding carboxyl-terminated poly lactic acid-glycolic acid, a solvent, a condensation agent and a polypeptide homopolymer into a reactor to obtain polypeptide-poly lactic acid-glycolic acid; 2) adding diisocyanate, polytetrahydrofuran, a catalyst and the solvent into the reactor for reacting for a period of time, adding dimethylolpropionic acid for reacting for a period of time, adding butanediol for reacting for a period of time, and adding butanol for reacting to obtain waterborne polyurethane; 3) adding amino-terminated poly lactic acid-glycolic acid, the solvent, the condensation agent and waterborne polyurethane into the reactor for reacting to obtain waterborne polyurethane-poly lactic acid-glycolic acid; and 4) adding polypeptide-poly lactic acid-glycolic acid, waterborne polyurethane-poly lactic acid-glycolic acid and the solvent into the reactor, mixing for a period of time, forming a film by a tape casting method, and drying to obtain a target object. The method disclosed by the invention is simple in preparation process, and the hydrophilicity and flexibility of the obtained modified film are greatly improved.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity and flexibility of a polypeptide film with polylactic acid glycolic acid and water-based polyurethane, and belongs to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide film is relatively stiff and lacks hydrophilicity, which limits its application. Poly(D,L) lactic acid glycolic acid has good biocompatibility and biodegradability, and is relatively soft. Waterborne polyurethane has good biocompatibility and biodegradability, and has good hydrophilicity. First, the poly(lactic-co-glycolic acid) segment is introduced into the polypeptide segment and the water-based polyurethane segment respectively to form a polypeptide-poly(lactic-co-glycolic acid) block copolymer and a water-based polyurethane-poly(lactic-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08L75/06C08L75/08C08J5/18C08G81/00C08G18/66C08G18/48C08G18/34C08G18/32C08G18/46
Inventor 朱国全谭洪生杜庆洋
Owner SHANDONG UNIV OF TECH
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