Veterinary parasite expelling orally disintegrating tablet

An orally disintegrating tablet and oral cavity technology, which is applied in the directions of pill delivery, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., to achieve the effects of good deworming effect, high dissolution rate and rapid disintegration.

Inactive Publication Date: 2015-05-06
SHENYANG VICA ANIMAL HUSBANDRY TECH +1
1 Cites 3 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0005] At present, the praziquantel preparations in veterinary medicine mainly include praziquantel powder, praziquantel tablets, and...
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Method used

In summary, the present invention makes praziquantel into orally disintegrating tablets, which is convenient for oral administration. That is, the bioavailability of medicine is improved, and the pain of taking medicine for animals is also reduced. Animals are easy to accept and also Vomiting will not occur. Through the optimization of disintegrants, fillers, flavoring agents, etc., insect repellent orally disintegrating tablets can be quickly disin...
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Abstract

The invention relates to a veterinary anthelmintic praziquantel oral disintegrating tablet, and belongs to the field of veterinary preparations. The formulation composition of the oral disintegrating tablet comprises praziquantel, a filling agent, a disintegrating agent, an adhesive, a flavoring agent and a lubricating agent. The oral disintegrating tablet comprises the following components in percentage by mass: praziquantel, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, crospovidone, a 60% ethanol solution of 3% polyvinylpyrrolidone, aspartame and magnesium stearate. Praziquantel oral disintegrating tablets which have pressure of over 4kg and disintegrating time within 60 seconds and are easy for industrial large-scale production are prepared from the components. The tablet has the advantages of good parasite expelling effect, high cure rate, less drug waste, high disintegrating speed, high dissolution rate, high stability, convenience in taking, easily available raw materials and low cost; meanwhile, a flavoring agent is added into the oral disintegrating tablet, so that the taste of the tablet is improved, the palatability is good, the administration compliance is improved, and the parasite expelling effect in clinical application is excellent. The veterinary anthelmintic praziquantel oral disintegrating tablet has a wide application prospect.

Application Domain

Organic active ingredientsPill delivery +2

Technology Topic

Magnesium stearateCrospovidones +19

Examples

  • Experimental program(1)
  • Effect test(1)

Example Embodiment

[0015] Example 1:
[0016] A veterinary anthelmintic praziquantel orally disintegrating tablet, the constituent components and their weight mass fractions are respectively (proportioned per 100g raw materials)
[0017] Praziquantel: 20g
[0018] Microcrystalline cellulose: 50g
[0019] Low-substituted hydroxypropyl cellulose: 5g
[0020] Sodium starch glycolate: 10g
[0021] Crospovidone: 8g
[0022] 5% polyvinylpyrrolidone in 60% ethanol solution: 20g
[0023] Aspartame: 5g
[0024] Magnesium stearate: 1g
[0025] Preparation method: Weigh the formula amount of praziquantel, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, crospovidone, aspartame, and sodium starch glycolate 1/2 the formula amount, respectively, through 80 mesh After sieving, mixing uniformly, adding 20 grams of 5% polyvinylpyrrolidone in 60% ethanol solution to make soft material, and drying at 60°C for 12 hours. The dried particles are sorted through a 16-mesh sieve, and then the whole particles are passed through a 60-mesh sieve to remove the fine powder, which can be left for the next batch of granulation. After granulation, add the amount of magnesium stearate and sodium starch glycolate 1/2 the formula amount, mix evenly, take the intermediate product to test the content, and determine the average tablet weight. The tablet is compressed to make the tablet smooth and beautiful, and the tablet weight is controlled at 475mg-525mg.
[0026] Quality inspection test results:
[0027] Taste: no bitterness, no obvious stimulation
[0028] Disintegration time: <1min
[0029] 15min dissolution (PH1.0, pulp method, 1000ml, 75rpm): 95%

PUM

no PUM

Description & Claims & Application Information

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