Veterinary parasite expelling orally disintegrating tablet

An orally disintegrating tablet and oral cavity technology, which is applied in the directions of pill delivery, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., to achieve the effects of good deworming effect, high dissolution rate and rapid disintegration.

Inactive Publication Date: 2015-05-06
SHENYANG VICA ANIMAL HUSBANDRY TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the praziquantel preparations in veterinary medicine mainly include praziquantel powder, praziquantel tablets, and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0015] Example 1:

[0016] A veterinary anthelmintic praziquantel orally disintegrating tablet, the constituent components and their weight mass fractions are respectively (proportioned per 100g raw materials)

[0017] Praziquantel: 20g

[0018] Microcrystalline cellulose: 50g

[0019] Low-substituted hydroxypropyl cellulose: 5g

[0020] Sodium starch glycolate: 10g

[0021] Crospovidone: 8g

[0022] 5% polyvinylpyrrolidone in 60% ethanol solution: 20g

[0023] Aspartame: 5g

[0024] Magnesium stearate: 1g

[0025] Preparation method: Weigh the formula amount of praziquantel, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, crospovidone, aspartame, and sodium starch glycolate 1 / 2 the formula amount, respectively, through 80 mesh After sieving, mixing uniformly, adding 20 grams of 5% polyvinylpyrrolidone in 60% ethanol solution to make soft material, and drying at 60°C for 12 hours. The dried particles are sorted through a 16-mesh sieve, and then the whole particles are ...

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Abstract

The invention relates to a veterinary anthelmintic praziquantel oral disintegrating tablet, and belongs to the field of veterinary preparations. The formulation composition of the oral disintegrating tablet comprises praziquantel, a filling agent, a disintegrating agent, an adhesive, a flavoring agent and a lubricating agent. The oral disintegrating tablet comprises the following components in percentage by mass: praziquantel, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, crospovidone, a 60% ethanol solution of 3% polyvinylpyrrolidone, aspartame and magnesium stearate. Praziquantel oral disintegrating tablets which have pressure of over 4kg and disintegrating time within 60 seconds and are easy for industrial large-scale production are prepared from the components. The tablet has the advantages of good parasite expelling effect, high cure rate, less drug waste, high disintegrating speed, high dissolution rate, high stability, convenience in taking, easily available raw materials and low cost; meanwhile, a flavoring agent is added into the oral disintegrating tablet, so that the taste of the tablet is improved, the palatability is good, the administration compliance is improved, and the parasite expelling effect in clinical application is excellent. The veterinary anthelmintic praziquantel oral disintegrating tablet has a wide application prospect.

Description

Technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to an orally disintegrating tablet of anthelmintic praziquantel for veterinary use. Background technique [0002] According to relevant statistics, the incidence of parasitic diseases accounts for about 8% of the incidence of livestock, especially sheep, and its incidence is higher, accounting for about 20-30%. Parasites are very harmful to livestock. They are various and widely distributed. They often destroy the health of animals in a very hidden way, inhibit the growth and development of young animals, greatly weaken the production performance of livestock, and reduce the quantity and quality of livestock products. The harm of parasites to livestock is mainly manifested in the following aspects: directly absorbing the nutrition of livestock; destroying, swallowing or digesting the tissue cells of livestock; Allergic reaction of histiocytes; mechanical obstruction of t...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4985A61K47/36A61K47/32A61P33/10A61P33/12
Inventor 赵蕾蕾赵宝凯虞正伟王洪礼
Owner SHENYANG VICA ANIMAL HUSBANDRY TECH
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