A kind of hydrogel system loaded with platinum drugs and preparation method thereof
A platinum-based drug and hydrogel technology, which is applied to the platinum-based drug-loaded hydrogel system and the field of preparation thereof, can solve problems such as limiting the scope of application, and achieve increased toxic and side effects, long-acting and controllable drug release, and preparation. simple craftsmanship
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Embodiment 1
[0024] 1) Dissolve 20.0 g N-isopropylacrylamide, 1.0 g carboxymethyl chitosan and 0.4 g N, N′-methylenebisacrylamide in 250 mL double distilled water at room temperature;
[0025] 2) Nitrogen gas for 30 minutes to remove oxygen from the solution in 1);
[0026] 3) Add 0.4 g ammonium persulfate and 0.4 g N, N, N', N'-tetramethylethylenediamine to the solution in 2), seal it, and put it in a refrigerator at 4 °C for 1 h;
[0027] 4) Take the solution in 3) out of the refrigerator and react at room temperature for 24 h;
[0028] 5) Soak the hydrogel obtained in 4) in distilled water for 3-5 days for purification, and change the water every 8 hours;
[0029] 6) Pre-freeze the hydrogel purified in 5), and dry it in a freeze dryer for 1-2 days;
[0030] 7) Weigh 5 g of dried hydrogel into 105 g, 1 mg / mL cisplatin aqueous solution and soak for 48 h;
[0031] 8) Take out the drug-loaded hydrogel, rinse it with distilled water for 3 times, pre-freeze it and dry it in a freeze dryer ...
Embodiment 2
[0033] 1) Dissolve 20.0 g N-isopropylacrylamide, 1.0 g carboxymethyl chitosan and 0.4 g N, N′-methylenebisacrylamide in 250 mL double distilled water at room temperature;
[0034] 2) Nitrogen gas for 30 minutes to remove oxygen from the solution in 1);
[0035] 3) Add 0.4 g ammonium persulfate and 0.4 g N, N, N', N'-tetramethylethylenediamine to the solution in 2), seal it, and put it in a refrigerator at 4 °C for 1 h;
[0036] 4) Take the solution in 3) out of the refrigerator and react at room temperature for 24 h;
[0037] 5) Soak the hydrogel obtained in 4) in distilled water for 3-5 days for purification, and change the water every 8 hours;
[0038] 6) Pre-freeze the hydrogel purified in 5), and dry it in a freeze dryer for 1-2 days;
[0039] 7) Weigh 5 g of dried hydrogel into 105 g, 2 mg / mL cisplatin aqueous solution and soak for 48 h;
[0040] 8) Take out the drug-loaded hydrogel, rinse it with distilled water for 3 times, pre-freeze it and dry it in a freeze dryer ...
Embodiment 3
[0042] 1) Dissolve 20.0 g N-isopropylacrylamide, 1.0 g carboxymethyl chitosan and 0.4 g N, N′-methylenebisacrylamide in 250 mL double distilled water at room temperature;
[0043] 2) Nitrogen gas for 30 minutes to remove oxygen from the solution in 1);
[0044] 3) Add 0.4 g ammonium persulfate and 0.4 g N, N, N', N'-tetramethylethylenediamine to the solution in 2), seal it, and put it in a refrigerator at 4 °C for 1 h;
[0045] 4) Take the solution in 3) out of the refrigerator and react at room temperature for 24 h;
[0046] 5) Soak the hydrogel obtained in 4) in distilled water for 3-5 days for purification, and change the water every 8 hours;
[0047] 6) Pre-freeze the hydrogel purified in 5), and dry it in a freeze dryer for 1-2 days;
[0048] 7) Weigh 5 g of dried hydrogel into 105 g, 1.5 mg / mL carboplatin aqueous solution and soak for 48 h;
[0049] 8) Take out the drug-loaded hydrogel, rinse it with distilled water for 3 times, pre-freeze it and dry it in a freeze dr...
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