Diminazene aceturate production method
A production method and a triazamidine technology are applied in the field of broad-spectrum anti-blood protozoal drug manufacturing and production, which can solve the problems of unfavorable industrialized production, high synthesis temperature, high methanol volatilization and the like, so as to save reaction time, avoid high temperature reaction, and reduce volatilization Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Example Embodiment
[0037] Example 1:
[0038] (1) Preparation of p-nitrobenzonitrile:
[0039] A. Use toluene as a solvent to dissolve p-nitrobenzamide to prepare a p-nitrobenzamide solution; the weight of p-nitrobenzamide is 70, and the weight of toluene is 800;
[0040] B. Put the p-nitrobenzamide solution into the reaction kettle, add triethylamine and thionyl chloride to react, set the reaction temperature to 100°C, and the reaction time to 10h; the weight parts of triethylamine is 4; chlorine The weight parts of sulfoxide is 95;
[0041] C. Cool down to 20°C, add 500 parts by weight of water and stir for 20 minutes to dilute, add 30% sodium hydroxide solution to neutralize to pH 7, filter and put into the liquid separator to separate the water, The toluene layer was heated to 110°C to distill the toluene out, and the filter was filtered twice in a spin filter, and dried at 60°C to obtain a p-nitrobenzonitrile filter cake; 10 parts by weight of the sodium hydroxide solution;
[0042] (2) Addition an...
Example Embodiment
[0056] Example 2:
[0057] (1) Preparation of p-nitrobenzonitrile:
[0058] A. Use toluene as a solvent to dissolve p-nitrobenzamide to prepare a p-nitrobenzamide solution; the weight of p-nitrobenzamide is 80, and the weight of toluene is 900;
[0059] B. Put the p-nitrobenzamide solution into the reaction kettle, add triethylamine and thionyl chloride to react, set the reaction temperature to 110°C, and the reaction time to 12h; the weight of triethylamine is 5; chlorine The weight parts of sulfoxide is 100;
[0060] C. Cool down to 30°C, add 620 parts by weight of water and stir for 30 minutes to dilute, add 30% sodium hydroxide solution to neutralize the pH to 7, after filtering, put it into the liquid separator to separate the water, The toluene layer was heated to 110°C to distill the toluene out, and the filter was filtered twice in a spin filter, and dried at 60°C to obtain a p-nitrobenzonitrile filter cake; the weight of sodium hydroxide solution was 20 parts;
[0061] (2) Ad...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap