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Preparation methods and application of ganoderma lucidum superfine powder

A technology of Ganoderma lucidum superfine powder and Ganoderma lucidum, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of uneven particle size, large particle size range, and high process cost, so as to improve the dissolution rate, Reduce production cost, the effect of particle uniformity

Active Publication Date: 2015-05-27
江苏海王健康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dong Yining et al.’s patent “Preparation Method of Ganoderma Lucidum Solid Beverage” (Application No. 201410157714.3) proposes that the particle size of ultrafine powder of Ganoderma lucidum fruiting body is 20-50 μm; "Preparation method" patent (application number 201410316806.1) proposes that the particle size of the powder is in the range of 0.01 μm to 150 μm; Shen Lirong et al. applied for a patent (application number 201110420345.9) of "a preparation method and application of pollution-free Ganoderma lucidum ultrafine powder" to propose a powder The average particle size is 100% below 9.96 μm, and the median particle size D50 is 2.92 μm; it can be seen that the particle size range of the existing technology is within 0.01 μm to 150 μm, the particle size range spans large, the particles are uneven, and the utilization rate of active ingredients is low , high process cost

Method used

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  • Preparation methods and application of ganoderma lucidum superfine powder
  • Preparation methods and application of ganoderma lucidum superfine powder
  • Preparation methods and application of ganoderma lucidum superfine powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 prepares Ganoderma lucidum superfine powder

[0035] The method for preparing Ganoderma lucidum superfine powder in the present embodiment, concrete steps are as follows:

[0036] 1) Use Ganoderma lucidum as raw material, remove impurities, wash with drinking water 3 to 5 times, water pressure 10MPa, slice the cleaned Ganoderma lucidum, and then coarsely grind it to below 80 mesh.

[0037] 2) The ganoderma lucidum powder that has been coarsely powdered is ultrafinely pulverized by a high-energy nano-impact mill, and the grinding medium in the high-energy nano-impact mill tank is continuously impacted and ground for 6 to 10 hours, so that the average particle size of the ultra-fine ganoderma powder reaches 100 ~900nm.

[0038] The production details are shown in Table 1:

[0039] Table 1

[0040] Production batch

[0041] (Remarks: These 3 batches have the same process, but the amount of raw materials is different.)

Embodiment 2

[0042] Embodiment 2 prepares Ganoderma lucidum superfine powder

[0043] The method for preparing Ganoderma lucidum superfine powder in the present embodiment, concrete steps are as follows:

[0044] 1) Raw material processing: take Ganoderma lucidum as raw material, remove the sundries, wash with drinking water 3 to 5 times, water pressure 10MPa, slice Ganoderma lucidum, and put it into the extraction tank;

[0045] 2) Water extraction: add distilled water 5, boil the Ganoderma lucidum in step 1 in an extraction tank and keep boiling for 1 hour, filter to obtain the Ganoderma lucidum water extract and Ganoderma lucidum residue. Add the Ganoderma lucidum residue into distilled water, keep boiling for 30 minutes after boiling, and filter to obtain the Ganoderma lucidum water extract and Ganoderma lucidum residue A;

[0046] 3) Drying of the water extract: combine the Ganoderma lucidum water extracts in step 2), put them in a rotary evaporator, 60 ° C ~ 80 ° C, reduce pressure ...

Embodiment 3

[0054] The method for preparing Ganoderma lucidum superfine powder in the present embodiment, concrete steps are as follows:

[0055] 1) Raw material processing: use high-quality, mildew-free Ganoderma lucidum as raw material, remove the sundries, wash with drinking water for 3 to 5 times, water pressure 10MPa, slice the Ganoderma lucidum, and put it into the extraction tank;

[0056] 2) Alcohol extraction: add 50 L of 75% ethanol to the Ganoderma lucidum in step 1, heat to reflux for 45 minutes, and filter to obtain the Ganoderma lucidum alcohol extract and Ganoderma lucidum residue. Add Ganoderma lucidum residue to 25L of 75% ethanol, heat to reflux for 45min, filter to obtain Ganoderma lucidum ethanol extract and Ganoderma lucidum residue A;

[0057] 3) Drying of Ganoderma lucidum ethanol extract: combine the Ganoderma lucidum ethanol extracts in step 2), put them in a rotary evaporator, and conduct rotary evaporation under reduced pressure at 60°C to 80°C to obtain Ganoder...

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Abstract

The invention provides preparation methods and application of ganoderma lucidum superfine powder. The invention provides the following three preparation methods: (1) direct superfine grinding; (2) firstly extracting ganoderma lucidum with water to obtain an aqueous extract of ganoderma lucidum and then evenly mixing with ganoderma lucidum residue superfine powder to prepare the ganoderma lucidum superfine powder; and (3) extracting ganoderma lucidum with alcohol to obtain an alcohol extract of ganoderma lucidum, and then evenly mixing with the ganoderma lucidum residue superfine powder to prepare the ganoderma lucidum superfine powder, wherein the mean particle size of the ganoderma lucidum superfine powder is 100-900nm. The invention provides formulas of tablet, capsule and granule products of the ganoderma lucidum superfine powder and the preparation techniques thereof on the basis of the ganoderma lucidum superfine powder. According to the novel preparation technology, such problems of existing ganoderma lucidum products as low active ingredient content and complicated production technology are solved; the utilization rate of the ganoderma lucidum is increased; and the productivity efficiency is improved. The prepared product is detected to prove the conclusion of high effective component content of the ganoderma lucidum superfine powder product.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine processing technology and preparations, and in particular relates to a preparation method and a preparation process of ganoderma lucidum superfine powder for anti-tumor and hypoglycemic properties. Background technique [0002] Ganoderma lucidum, also known as Ganoderma lucidum, Shenzhi, Zhicao, Xiancao, and Ruicao, is the whole plant of Chizhi or Zizhi, a plant of Polyporaceae. It is known that there are more than 100 species of fungi in the genus Ganoderma, and the most widely distributed one is G.lu-cidum, followed by G. japonicum, and G.applana-tum, pine fir Ganoderma lucidum (G.tsugae) and book Shuzhi (G.capense) etc. are used for medicine. "Compendium of Materia Medica" records: Ganoderma lucidum tastes bitter, flat, non-toxic, beneficial to the heart, promotes blood circulation, enters the heart to congest the blood, helps the heart to fill the pulse, soothes the nerves, nourish...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/20A61P35/00A61P3/10
Inventor 严启新徐玮曾琪钟灵玉吕杰王巍程维茂宋廷久
Owner 江苏海王健康生物科技有限公司
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