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Preparation method of Zhongganling capsules and quality detection method of Zhongganling capsules

A technology of Chongganling and capsules, which is applied in the field of new preparation technology and quality inspection of the Chinese and Western medicine compound preparation "Chongganling Capsule", which can solve the problems of difficult control of preparation quality, destruction of active ingredients, long heating time, etc., and eliminate Bad effects, energy saving, process convenience effects

Inactive Publication Date: 2015-06-03
PROZIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the long time of decoction and drying of the extract, some thermally unstable active ingredients are easily destroyed, and the quality of the preparation is difficult to control, which is not conducive to the realization of modern production of preparations.

Method used

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  • Preparation method of Zhongganling capsules and quality detection method of Zhongganling capsules
  • Preparation method of Zhongganling capsules and quality detection method of Zhongganling capsules
  • Preparation method of Zhongganling capsules and quality detection method of Zhongganling capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Extraction: take 4.69Kg of Chinese herbal medicines Ilex pubescens, 4.69Kg of Pueraria lobata, 3.12Kg of verbena, 2.5Kg of Radix isatidis, and 1.25Kg of Artemisia annua, crushed through 60 mesh, soaked in 975Kg of water for 1.5 hours, and then extracted with ultrasonic waves at a bath temperature of 65°C The filter was extracted at 40kHz for 45min, and then filtered to obtain a filtrate. Add 812.5Kg water to the filter residue, extract with an ultrasonic extractor at 35kHz for 40min at a bath temperature of 60°C, filter to obtain the second filtrate; combine the two extracts, and depressurize at a vacuum degree of 0.85-0.95Mpa and 60-70°C Concentrate to a relative density of 1.20 (60 ° C) extract to obtain water extract extract.

[0021] Drying: Spray-dry the water extract extract prepared above with a centrifugal spray dryer: the feed temperature of the extract is kept at 60°C-75°C; ℃~75℃; the rotating speed of the centrifugal atomizer is 40Hz, and the feeding speed i...

Embodiment 2

[0029] Extraction: Take 9.38Kg of Chinese herbal medicines Ilex pubescens, 9.38Kg of Pueraria lobata, 6.24Kg of verbena, 5.0Kg of Radix isatidis, and 2.50Kg of Artemisia annua, crush them through 60 meshes, soak them in 1950Kg of water for 2.0 hours, and then use ultrasonic waves at a bath temperature of 70°C. The extractor extracts at 40kHz for 50min, and then filters to obtain a filtrate. Add 1625Kg water to the filter residue, extract with an ultrasonic extractor at 40kHz for 40min at a bath temperature of 70°C, filter to obtain the second filtrate; combine the two extracts, and concentrate under reduced pressure at a vacuum degree of 0.85-0.95Mpa and 60-70°C To the relative density of 1.20 (60 ℃) extract, water extract extract.

[0030]Drying: Spray-dry the water extract extract prepared above with a centrifugal spray dryer: the feed temperature of the extract is kept at 60°C-75°C; ℃~75℃; the rotating speed of the centrifugal atomizer is 40Hz, and the feeding speed is 10m...

Embodiment 3

[0038] Extraction: Take 2.48Kg of Chinese herbal medicines Ilex pubescens, 2.48Kg of Pueraria lobata, 1.56Kg of verbena, 1.25Kg of Radix isatidis, and 0.63Kg of Artemisia annua, crush them through 60 meshes, soak them in 487Kg of water for 1.5 hours, and then use ultrasonic waves at a bath temperature of 70°C. The extractor extracts at 35kHz for 50min, and then filters to obtain a filtrate. Add 406Kg of water to the filter residue, extract with an ultrasonic extractor at 35kHz for 40min at a bath temperature of 60°C, and filter to obtain a secondary filtrate; combine the two extracts and concentrate under reduced pressure at a vacuum degree of 0.85-0.95Mpa at 60-70°C To the relative density of 1.20 (60 ℃) extract, water extract extract.

[0039] Drying: Spray-dry the water extract extract prepared above with a centrifugal spray dryer: the feed temperature of the extract is kept at 60°C-75°C; the spray tower is maintained at a temperature of 130°C-140°C, The temperature is 70°...

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Abstract

The invention belongs to the field of medicine preparations, and discloses a preparation method of Zhongganling capsules and a quality detection method of the Zhongganling capsules. The preparation method is characterized in that the Zhongganling capsules are prepared by pubescent holly roots, radix puerariae, verbena officinalis, radix isatidis, artemisia apiacea, notopterygium roots, gypsum, chlorpheniramine maleate and analgin. The preparation method comprises the steps that pubescent holly roots, radix puerariae, verbena officinalis, radix isatidis and artemisia apiacea are subjected to ultrasonic extraction by taking water as a solvent to form a water extract; the water extract is subjected to spray drying to form water extract dried miropowder; notopterygium roots and gypsum powder are broken into micropowder, and combined with Western medicines: chlorpheniramine maleate and analgin, and mixed uniformly; alcohol granulation is performed; encapsulation in capsules is performed, so that the Zhongganling capsules are obtained. The preparation method adopts an ultrasonic extraction method, so that active ingredients in cells of the crude drugs can be dissolved out rapidly; the active ingredient extraction yield is high; the extraction time is short; and the energy is saved. In addition, a quality detection standard is formulated for extracts of traditional Chinese medicines, so that the product quality problem due to the fact that indexes and ingredients of an extract in the original process are uncertain and particles of medicinal powder are too coarse is solved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a new preparation process and a quality detection method of a Chinese and Western medicine compound preparation "Chongganling Capsule". Background technique [0002] Chongganling Capsules are produced from the nineteenth volume of "Drug Standards of the Ministry of Health of the People's Republic of China" (Chinese Medicine Prescriptions) "Chongganling Tablets" [0003] To change the dosage form. The prescription of the medicine is composed of hairy wintergreen, notopterygium, kudzu root, gypsum, verbena, isatis root, artemisia annua, chlorine maleate [0004] A Chinese and Western medicine compound preparation composed of 9 medicines of pheniramine and analgin. Function cures mainly for expelling exterior and clearing away heat, dispelling wind and relieving pain. used to express evil [0005] Severe cold caused by unresolved, turbid heat, symptoms inc...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/48G01N30/90A61P11/00
Inventor 肖军平吴永忠刘立鼎陈梁杨伟庆康兴东
Owner PROZIN PHARMA CO LTD
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