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A household microfluidic chip and its application method

A microfluidic chip and chip technology, applied to chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of high material cost, low price, long processing cycle, etc., and achieve low price, Easy operation and easy mass production

Active Publication Date: 2017-01-04
BEIJING BAIKANGXIN BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sales volume in the household market is usually very large, and the price is not high, which requires that the chip should be made of cheap materials, and the processing and molding technology is mature; wet etching cannot be used because the processing cycle is too long; it is best not to use PDMS materials, because high material cost

Method used

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  • A household microfluidic chip and its application method
  • A household microfluidic chip and its application method
  • A household microfluidic chip and its application method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The microfluidic chip of the present embodiment comprises two layers of a bottom sheet and a cover sheet, the bottom sheet is glass with a thickness of 1 mm, and the cover sheet is a PC plate with a thickness of 2 mm (such as figure 1shown), the chip is located on the negative,. There are structures such as channels and micro-pools on the cover slip, but no structures on the bottom slip. The cover sheet can be made by existing technologies such as laser engraving, machining or injection molding. The negative film is purchased in batches, and the negative film and the cover film are sealed together by glue.

[0052] The chip includes a main channel 101 and a micro pool 102 communicating with the main channel 101 , and also includes a holding pool 103 and an exhaust hole 104 . There are also two glands 106 on the cover sheet, which are used to seal the holding pool 103 and the exhaust hole 104 respectively. There is a buckle 501 on the gland 106, which is convenient for...

Embodiment 2

[0063] The microfluidic chip of the present embodiment comprises two layers, and the bottom sheet is a PP film with a thickness of 0.2 mm, and the cover sheet is a PP sheet with a thickness of 5 mm (such as image 3 shown). There are structures such as channels and micro-pools on the cover slip, but no structures on the bottom slip. The cover sheet and the bottom sheet can be made by existing technologies such as laser engraving, mechanical processing or injection molding, and the cover sheet and the bottom sheet are sealed together by hot pressing.

[0064] The chip includes a main channel 101 and six micro-cells 102 communicated with the main channel 101 through sub-channels 502 , and also includes a holding pool 103 and six exhaust holes 104 . There is also a gland 106 on the cover sheet, and there are two protrusions 803 on the gland, corresponding to the sealed storage pool 103 and the exhaust hole 104 . The use of protrusion 803 instead of 801 rubber pad is because the...

Embodiment 3

[0079] Such as Figure 5 As shown, the microfluidic chip of this embodiment is similar to that of Embodiment 2, but the vent hole 104 is covered with a layer of hydrophobic gas-permeable film 805, which is made of polyvinylidene fluoride film (PVDF film, purchased from Millipore Corporation, Thickness 0.2mm). Attach the PVDF membrane to the coverslip with double-sided tape.

[0080] Because of the blocking effect of the hydrophobic gas-permeable membrane, the reagent will not overflow. In this way, the chip does not need to be deliberately placed horizontally when adding samples, which is more suitable for untrained ordinary users.

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Abstract

The invention provides a domestic micro-fluidic chip. A chip body is located on a substrate and comprises a bottom piece and a cover piece, wherein the bottom piece and the cover piece are sealed to form a whole body; the chip comprises at least one main channel and at least one micro-tank communicated with the main channel; the main channel is communicated with at least one containing tank and at least one exhausting hole; at least one face of each of the main channel and the micro-tank is hydrophilic; the chip further comprises at least one pressing cover; when the pressing cover is pressed, the containing tank and the exhausting hole are sealed; and the bottom piece and / or the cover piece are / is made of a high molecular material. The invention further provides an application method of the chip. The chip has the advantages that a user can simply and conveniently add a sample and an opening is easy to seal; the chip is easy to manufacture in batches and is very suitable for the field of domestic detection; and the chip can be expanded in the fields of inspection and quarantine, rapid detection on battlefields, and the like.

Description

technical field [0001] The invention relates to a household microfluidic chip and an application thereof, belonging to the field of microfluidic chips and the field of biological detection. Background technique [0002] Microfluidic chip is based on micro-electromechanical processing technology, which forms a network on the chip by micro-pipelines, and uses controllable micro-fluids to run through the entire system and complete various biological and chemical processes. In the early stage of the development of microfluidic chip technology, chip capillary electrophoresis was the mainstream technology, and the chip used was simple in structure and single in function; Important biological and chemical processes such as reaction and cell lysis have become new hotspots. With the development of the industry, the application field of microfluidic chips has gradually expanded from laboratories and clinical hospitals to the home market, and users have also changed from professionals...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
Inventor 张国豪
Owner BEIJING BAIKANGXIN BIOLOGICAL SCI & TECH