Method for preparing conjugated linoleic acid

A technology of conjugated linoleic acid and linoleic acid ester, which is applied in the direction of fatty acid preparation/refining, fatty acid production, fatty acid esterification, etc., and can solve problems such as lack of conjugated linoleic acid

Inactive Publication Date: 2015-06-03
WILMAR SHANGHAI BIOTECH RES & DEV CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In summary, there is a lack of a method in the art that can efficiently prepare conjugated linoleic acid, so that

Method used

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  • Method for preparing conjugated linoleic acid
  • Method for preparing conjugated linoleic acid
  • Method for preparing conjugated linoleic acid

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preparation example Construction

[0112] One, the preparation of ethyl linoleate:

[0113] Raw material 1: Refined safflower oil (acid value below 0.1),

[0114]Preparation process: Take 50 parts of absolute ethanol, add 0.5 parts of catalyst KOH in oil weight, and dissolve it. Then add it to 100 parts of refined safflower oil, raise the temperature to 75°C, and stir for 4 hours. After the reaction, wash with water until neutral, remove the lower layer, take the upper liquid phase, dry it, and weigh it. Vacuum distillation (8-10pa) at about 170°C until no liquid drips out to obtain ethyl linoleate.

[0115] After testing, the prepared ethyl linoleate content was 77%.

[0116] Two, the preparation of conjugated linoleic acid ester:

Embodiment 1

[0118] Weigh 100g of ethyl linoleate (raw material 1) into the reaction kettle, replace the air with nitrogen, raise the temperature to 100°C, add 4g of butyllithium, and keep stirring. After 3 hours of reaction, add 23g of glycerol triacetate, Turn on the vacuum and heat up to 140°C, cool to 60°C after 2.5 hours, add phosphoric acid aqueous solution to neutralize and wash with water, dry and molecularly distill off the remaining conjugated linoleic acid ethyl ester at 180°C to obtain conjugated linoleic acid triglyceride, Detect its fatty acid composition as follows.

[0119] Table 1 The percentage content of conjugated linoleic acid

[0120] index detection value Regulatory requirements 9cis,11trans conjugated linoleic acid 37.6% 37.5%～42% 10 trans,12 cis conjugated linoleic acid 37.9% 37.5%～42% Oleic acid content 11.3% 10%～20% Linoleic acid content 0.2% <3%

Embodiment 2

[0122] Weigh 100g of ethyl linoleate (raw material 1) into the reaction kettle, replace the air with nitrogen, raise the temperature to 125°C, add 5g of benzyllithium, and keep stirring. After 4 hours of reaction, add 23g of glycerol triacetate, Turn on the vacuum and heat up to 140°C, cool to 60°C after 2.5 hours, add phosphoric acid aqueous solution to neutralize and wash with water, dry and molecularly distill off the remaining conjugated linoleic acid ethyl ester at 180°C to obtain conjugated linoleic acid triglyceride, Detect its fatty acid composition as follows.

[0123] The percentage content of table 2 conjugated linoleic acid

[0124] index detection value Regulatory requirements 9cis,11trans conjugated linoleic acid 38.0% 37.5%～42% 10 trans,12 cis conjugated linoleic acid 37.9% 37.5%～42% Oleic acid content 11.1% 10%～20% Linoleic acid content 0.2% <3%

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Abstract

The invention provides a method for preparing conjugated linoleic acid. The method comprises the following steps: reacting linoleate under catalysis of organic base of which the pKa is more than 11, thereby obtaining the conjugated linoleic acid ester. Furthermore, an ester exchange reaction can be carried out between the conjugated linoleic acid ester and glycerin or derivatives thereof, and conjugated linoleic acid glyceride is prepared. By utilizing the conjugated linoleic acid prepared by the invention, the reaction conversion rate is high, and the content of fatty acids in the conjugated linoleic acid product meets the related statutory and regulatory requirements.

Description

technical field [0001] The invention relates to a method for preparing conjugated linoleic acid. Background technique [0002] Conjugated linoleic acid (CLA) is a group of isomers of linoleic acid derived from linoleic acid, which is commonly found in nutrients in humans and animals. In human food, it mainly comes from dairy products, beef and mutton, and contains lipids in human serum and other tissues such as adipose tissue. It can reduce fat accumulation in the body and play a role in lipid and glucose metabolism. [0003] Natural vegetable oil rich in linoleic acid triglyceride is usually selected as an important raw material for the preparation of conjugated linoleic acid and its derivatives. Conjugated linoleic acid can be prepared by alkali-catalyzed transesterification and saponification isomerization, except for 10 , 12 cis / 9 cis, 11 trans are two functional isomers, other CLA isomers are especially 9 cis, 11 trans; 10 cis, 12 cis; 11 cis, 13 cis and other all cis...

Claims

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Application Information

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IPC IPC(8): C11C1/04
CPCC11C1/04C11B1/00C11C3/10
Inventor 郭涛张海王勇
Owner WILMAR SHANGHAI BIOTECH RES & DEV CENT
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