Method for loading 5-fluorouracil by using metal-organic framework material

Abstract

The invention relates to a method for loading 5-fluorouracil by using a metal-organic framework material. The method comprises the following steps: adding the nanoscale metal-organic framework material (MOF) synthesized by a hydrothermal method into a 5-fluorouracil aqueous solution; and carrying out operations such as stirring, gradient cooling, filtering, centrifugalizing, freezing and drying and the like to prepare the MOF / 5-fluorouracil compound. The drug loading method has the advantages of controlled drug release, simple operation, no organic solvents and the like.

Description

technical field

[0001] The invention relates to a method for loading 5-fluorouracil by using a metal-organic framework material, and belongs to the fields of biomedicine and material chemistry. Background technique

[0002] 5-Fluorouracil is a broad-spectrum antitumor drug, especially for digestive system tumors, such as the basic drug for chemotherapy of liver cancer. At present, there are many disadvantages in the clinical use of 5-fluorouracil, such as difficult absorption after oral administration, fast metabolism in the body, short half-life (only 5-10 minutes), toxic and side effects, etc., and it needs large doses of long-term intravenous infusion to reach the effective concentration in the body and duration of action. In order to reduce the toxic and side effects of 5-fluorouracil and improve the utilization rate of the drug, it can be mixed with biodegradable polymer materials to make drug-loaded microspheres with sustained release, and the drug can be enriched aro...