Halometasone cream and preparation method thereof

Abstract

The invention relates to a halometasone cream, which is characterized by containing, per gram, 0.0005g of halometasone monohydrate, 0.00045-0.00055g of ascorbyl palmitate, 0.0405-0.0495g of cetanol, 0.036-0.044g of hexadecanol palmitate, 0.009-0.011g of sodium dodecyl sulfate, 0.0009-0.0011g of EDTA disodium, 0.054-0.066g of glycerin, 0.009-0.011g of 2-phenoxyethanol, 0.0495-0.0605g of propylene glycol, 0.036-0.044g of stearic acid, 0.0405-0.0495g of octadecyl alcohol, 0.045-0.055g of white Vaseline, and a proper amount of water.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a formula of halometasone cream with stable quality. Background technique [0002] Halometasone (halometasone, Halometasone), is a local adrenocortical hormone drug, has significant and rapid anti-inflammatory, anti-allergic, anti-itching, anti-exudation and anti-proliferation effects, suitable for eczema skin diseases and various Mild eczema and subacute dermatitis. The medicinal products of halometasone are mainly ointments for external use. The unilateral products that have been marketed are Novartis’s “Xiaquede” and Hong Kong Aomei Company’s “Aoneng”, as well as its compound product “Xinxuide” (per gram milk Ointment containing halometasone monohydrate 0.5 mg, triclosan 10 mg). These products have been on the market in China, Germany, Australia, Switzerland, South Africa and other countries for many years, and have important clinical applications. [0003] The chemical ...

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Problems solved by technology

[0007] Chinese patent document CN201110392044 mentions that the halometasone preparation of the prior art has problems such as unstable content and easy generation of impurities. The reason for the above problems is that the chemical properties of the active ingredient halometasone are very active and easy to deteriorate.

[0008] In addition, under the conditions of high temperature and high humidity, the stability of the cream is poor and it is not easy to store. Many creams need to be stored in a cool condition, such as: Aoneng (halometasone cream), Eloson (mometasone furoate cream) , Uzoll (hydrocortisone butyrate cream), DINK (terbinafine hydrochloride cream), etc., but people in high temperature and high humidity areas are relatively susceptible to skin diseases, so there is an urgent need to develop a product with better quality Good, more stable, especially halometasone cream that is more stable under high temperature and high humidity conditions

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