Method for continuously preparing N-ethyloxyl oxalyl alanine ethyl ester

A technology of ethyl ethoxy oxalyl alanine and diethyl oxalate is applied in the field of continuous preparation of vitamin B6 intermediate - N-ethoxy oxalyl alanine ethyl ester, and can solve the problem of mild reaction conditions , the lack of high yield, etc.
CN104725262AActive Publication Date: 2015-06-24DAFENG HEGNO PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DAFENG HEGNO PHARMA
Publication Date
2015-06-24

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Abstract

The invention discloses a method for continuously preparing N-ethyloxyl oxalyl alanine ethyl ester. The method for continuously preparing the N-ethyloxyl oxalyl alanine ethyl ester concretely comprises the following steps: (1) providing reaction feed liquid, wherein the reaction feed liquid contains alanine, oxalate, ethanol and diethyl oxalate; (2) adding the reaction feed liquid into a reaction device as a reaction system, and carrying out reaction in the presence of a water carrying agent, so that product water and the water carrying agent form a water-water carrying agent dispersion system, wherein the water carrying agent is ethanol; and (3) distilling off the water-water carrying agent dispersion system and removing excessive diethyl oxalate, thus obtaining the N-ethyloxyl oxalyl alanine ethyl ester product. The method for continuously preparing the N-ethyloxyl oxalyl alanine ethyl ester has the advantages that continuous and automatic production can be realized, and hypertoxic benzene is not used, so that the method for continuously preparing the N-ethyloxyl oxalyl alanine ethyl ester is more environmental-friendly; meanwhile, reaction time is short and energy consumption is low.
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Description

technical field

[0001] The invention relates to the technical field of vitamin production, in particular to a continuous preparation method of vitamin B6 intermediate-N-ethoxy ethyl oxalylalanine. Background technique

[0002] Vitamin B6 is one of the essential vitamins for the human body, which plays a vital role in the regulation of various physiological functions of the human body and growth and development. Vitamin B6 can maintain the balance of sodium and potassium in body fluids, regulate body fluids, and participate in the production of red blood cells. Therefore, it is often used in the treatment of vitamin B6 deficiency in the human body and adjuvant treatment of other diseases, and can also be used as food additives.

[0003] Ethyl N-ethoxy oxalylalanine is an important intermediate for the preparation of vitamin B6. At present, the disclosed methods for preparing this intermediate mainly include:

[0004] The method disclosed in US3646061 is to react alanine, oxa...

Claims

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