Intestine and stomach antibacterial drug composition, and intestine and stomach antibacterial drug containing intestine and stomach antibacterial drug composition and preparation thereof

A technology for antibacterial drugs and compositions, applied in the field of gastrointestinal antibacterial drugs and their preparation, and gastrointestinal antibacterial drug compositions, can solve the problems of many unknown components, complex components, difficult quality control, etc., and achieve good clinical efficacy and reduce production costs. Effect

Active Publication Date: 2015-07-01
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation also has complex components, many unknown components, and difficult quality control.

Method used

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  • Intestine and stomach antibacterial drug composition, and intestine and stomach antibacterial drug containing intestine and stomach antibacterial drug composition and preparation thereof
  • Intestine and stomach antibacterial drug composition, and intestine and stomach antibacterial drug containing intestine and stomach antibacterial drug composition and preparation thereof

Examples

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Effect test

Embodiment 1

[0027] A traditional Chinese medicine compound antibacterial drug, comprising the following components in parts by weight: 200 g of rhubarb rhizome, 100 g of rhubarb, 100 g of licorice, and 250 g of soluble starch. Its preparation method is as follows:

[0028] 1. Weigh 200g Coptidis rhizome, 100g rhubarb, and 100g licorice, soak in water with 8 times the weight of medicinal materials for 4 hours, heat and decoct for 2 hours for the first time, and add 8 times the weight of medicinal materials for decoction for 1 hour for the second time. Combine the decoction liquids, filter, let stand, take the supernatant and concentrate under reduced pressure to a thick paste with a relative density of 1.32 to 1.35 at 20°C.

[0029] 2. Add 250g of soluble starch to the thick paste, spray-dry and granulate, and pass through a 16-mesh sieve to obtain the product.

Embodiment 2

[0031] A traditional Chinese medicine compound antibacterial drug, comprising the following components in parts by weight: 100 parts by weight of Coptidis rhizome, 50 parts by rhubarb, 50 parts by licorice and 200 parts by weight. Its preparation method is as follows:

[0032] 1. Weigh 100g Coptis rhizome, 50g rhubarb, and 50g licorice, soak in water with 8 times the weight of the medicinal materials for 4 hours, heat and decoct, the first time for 2 hours, and add the dregs of the medicine for the second time to decoct for 1 hour with water 8 times the weight of the medicinal materials. Combine the decoction liquids, filter, let stand, take the supernatant and concentrate under reduced pressure to a thick paste with a relative density of 1.32 to 1.35 at 20°C.

[0033] 2. Add 200g of glucose to the thick paste, spray-dry and granulate, and pass through a 16-mesh sieve to obtain the product.

Embodiment 3

[0035] A traditional Chinese medicine compound antibacterial drug, comprising the following components in parts by weight: 300 g of rhubarb, 150 g of rhubarb, 150 g of licorice, 100 g of dextrin, and 200 g of sucrose. Its preparation method is as follows:

[0036] 1. Weigh 300g Coptidis rhizome, 150g rhubarb, and 150g licorice, soak in water with 8 times the weight of medicinal materials for 4 hours, heat and decoct for 2 hours for the first time, and add 8 times the weight of medicinal materials for decoction for 1 hour for the second time. Combine the decoction liquids, filter, let stand, take the supernatant and concentrate under reduced pressure to a thick paste with a relative density of 1.32 to 1.35 at 20°C.

[0037] 2. Add 300g of dextrin and 200g of sucrose to the thick paste, granulate through spray drying, and pass through a 16-mesh sieve to obtain the product.

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Abstract

The present invention relates to an intestine and stomach antibacterial drug composition, and an intestine and stomach antibacterial drug containing the intestine and stomach antibacterial drug composition and preparation thereof. The drug composition comprises, by weight, 100-300 parts of coptis chinensis, 50-150 parts of rheum palmatum, and 50-150 parts of licorice root. The intestine and stomach antibacterial drug comprises the drug composition, a pharmaceutically acceptable carrier and other drug auxiliary agents. The three traditional Chinese medicines such as coptis chinensis, rheum palmatum and licorice root are subjected to extraction processing to obtain an extract, and the extract and the drug auxiliary agents are mixed according to a certain ratio to prepare the intestine and stomach antibacterial drug. According to the intestine and stomach antibacterial drug composition and the intestine and stomach antibacterial drug of the present invention, the existing formula of the Sihuang dysentery stopping granules is simplified, the production cost is reduced, the clinical treatment efficacy is good, and the intestine and stomach antibacterial drug preparation prepared from the intestine and stomach antibacterial drug composition provides the same treatment effect compared with the existing Sihuang dysentery stopping granules.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a gastrointestinal antibacterial drug composition, an gastrointestinal antibacterial drug containing the composition and preparation thereof. Background technique [0002] A traditional preparation used for the treatment of damp-heat diarrhea and colibacillosis of chickens is Sihuang Zhili Granule, which is extracted and processed from 6 traditional Chinese medicines of Coptis chinensis, Cortex Phellodendron, Rhubarb, Scutellaria baicalensis, Radix Radix Radix, and Glycyrrhizae, and then mixed with The granules made by mixing sucrose and dextrin in a certain proportion have the effect of clearing away heat and purging fire and stopping dysentery. It is mainly used clinically for the treatment of damp-heat diarrhea and chicken colibacillosis, such as chicken E. coli, Pasteurella, Salmonella Damp-heat diarrhea, pullorum, yellow-white dysentery, watery diarrhea, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P31/04A61P1/00
CPCY02A50/30
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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