Method for preparing chitosan into water-soluble chitosan oligosaccharide

Abstract

The invention relates to a method for preparing chitosan into water-soluble chitosan oligosaccharide. The method is as below: rinsing and drying a raw material chitosan, soaking chitosan into a feed liquid prepared from clean water and food grade hydrogen peroxide, conducting microwave radiation degradation treatment to form a mixed solution of low molecular chitosan oligosaccharide dissoluble in the feed liquid and non-degraded chitosan, then filtering to obtain by chitosan residue and a chitosan oligosaccharide solution, subjecting the chitosan oligosaccharide solution to alcohol precipitation in ethanol, and conducting suction filtration and drying to obtain the water-soluble chitosan oligosaccharide product. Due to the microwave radiation degradation treatment technology and physical method for lasing energy, polymer chitosan degrades into low molecular water- soluble chitosan oligosaccharide with stable structure; and in the degradation process, no other reaction by-products or pollutants are generated. Compared with the preparation method in the prior art, the method has the advantages of advanced technology, simple process, less investment in production facilities, high product purity and stable quality, and opens broad market prospect for chitosan prepared from chitin as raw material.

Description

technical field [0001] The invention relates to the technical field of physical degradation, in particular to a method for preparing chitosan into water-soluble chitosan oligosaccharide. Background technique [0002] Chitosan oligosaccharide, also known as chitosan oligosaccharide, is a natural high-activity animal cellulose product made from chitosan obtained after deacetylation of chitin through high-tech degradation and separation methods. Due to its unique pharmacological effects and the resulting broad market application prospects, it has attracted increasing attention, and has even been praised as the "sixth vital element of the human body" and "soft gold". [0003] Chitin is a pure natural polymer compound, which is widely found in crustaceans such as shrimps and crabs, insects and algae. Its annual biosynthetic resources are as high as 10 billion tons, of which the production of marine organisms is about 10 It is the second largest inexhaustible natural biological r...

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Problems solved by technology

The disadvantage of the chemical degradation method is that it is easy to produce reaction by-products, which will eventually affect the purity of the product, so the product quality is difficult to control and the stability is poor; the enzymatic hydrolysis method uses certain enzymes to specifically crack and change the molecular structure to achieve the purpose of degradation. Since no other reaction by-products are generated during the entire degradation process, it has become a more commonly used method at present. Its disadvantages are that the process is relatively complicated, the degradation efficiency is low, and the product cost is high. At present, it is only in the stage of laboratory research and small batch trial production. There are still a series of technical problems to be solved for industrial scale production

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