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A composition for improving sleep and its preparation method

A technology for improving sleep and composition, which is applied in the field of sleep improving composition and its preparation, can solve the problems of lack of energy, increase the burden on the liver and kidney, and the effect is not confirmed, so as to improve sleep, increase the incidence of falling asleep, Toxic effects

Active Publication Date: 2017-12-26
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, not only the effects of these drugs are mostly unaffirmed, but most sleeping pills are metabolized by the liver and kidneys in the body. Long-term use will increase the burden on the liver and kidneys, and some will cause liver enlargement, pain in the liver area, jaundice, and edema , proteinuria, hematuria and nausea, abdominal distension, loss of appetite, constipation and other liver and kidney damage and gastrointestinal reactions
Some sleeping pills can also cause accumulated poisoning symptoms such as lack of energy, mental decline, and blood pressure drop, and even cause respiratory and circulatory dysfunction.

Method used

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  • A composition for improving sleep and its preparation method
  • A composition for improving sleep and its preparation method
  • A composition for improving sleep and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1 Preparation of freeze-dried apple stem cell powder

[0093] 1. The formula of the culture medium:

[0094] 1.1 Induction medium: MS solid medium+NAA0.5mg / L+BA2mg / L+CH 1mg / L, pH 6.0;

[0095] 1.2 Proliferation medium: MS liquid medium+2,4-D 2.0mg / L+BA1.0mg / L+CH1.0mg / L+AC1.0mg / L, pH value is 6.0;

[0096] 2. Sterilization of apple branches

[0097] Choose apple trees that are not polluted by chemical fertilizers and pesticides and are planted green, and select 10 new shoots of 10cm in length according to certain criteria; wash the surface attachments of the new shoots with 2L of sterile water; soak the new shoots in 120mg / L L-ascorbic acid 1 minute; sterilize the new shoots in 75% ethanol solution for 1 minute and rinse them with 2L sterile water; then sterilize them in 30% hydrogen peroxide solution for 20 minutes, and rinse with sterile water for 10 minutes.

[0098] 3. Induction of cambium

[0099] Use an inoculating knife to peel off the cambium, phloem, cortex and epi...

Embodiment 2

[0108] Example 2 Preparation of sleep-improving composition

[0109] First, 100g of freeze-dried apple stem cell powder, 100g of jujube seed extract, and 40g of γ-aminobutyric acid were pulverized (the freeze-dried apple stem cell powder was ground with liquid nitrogen, and the extract of jujube seed and γ-aminobutyric acid were subjected to ordinary Grind), pass a 100-mesh sieve, and then mix the crushed and sieved materials in a mixer.

Embodiment 3

[0110] Example 3 Preparation of sleep-improving composition

[0111] Firstly, 100g of freeze-dried apple stem cell powder, 100g of jujube seed extract, and 75g of γ-aminobutyric acid were pulverized. Grind), go through a 100-mesh sieve, and then mix the crushed and sieved materials in a mixer.

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Abstract

The invention relates to the technical field of health products and in particular relates to a composition for improving sleep and a preparation method thereof. The composition is characterized in that apple stem cell lyophilized powder, spina date seed extract and gamma-aminobutyric acid are compounded, the effect of obviously improving sleep is realized, and no toxic or side effect is produced. Experiments show that the effect for improving sleep of the provided composition is obviously better than the effects of respective components, and mouse acute toxicity test results show that abnormality is not found on a mouse and no poisoning or death phenomenon is caused; and the provided composition can effectively improve incidence that the mouse at subthreshold dose of pentobarbital sodium falls asleep at a dosage of 0.5g / kg.

Description

Technical field [0001] The present invention relates to the technical field of health products, in particular to a composition for improving sleep and a preparation method thereof. Background technique [0002] Modern fast-paced life and increasingly fierce competitive relationships have caused people to become more and more mentally stressed. Long-term mental tension and a series of irregular life rhythms have caused insomnia that has plagued most people. According to statistics, the number of insomniacs in our country accounts for 20% to 30% of the total population, of which 70% are middle-aged and elderly people. Long-term insomnia can easily cause upset, fatigue, fatigue, headache, dreaminess, sweating, memory loss, and can also cause a series of clinical symptoms and induce some psychosomatic diseases. The decrease in work efficiency due to physical pain increases the psychological pressure of insomniacs. In such a vicious circle, neurasthenia, endocrine disorders, etc. occ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61P25/20A61K31/197
Inventor 陈海佳王一飞葛啸虎黎娟妹戴国胜舒辉萍
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD