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Composite support containing PGA strengthening net, preparation method and applications thereof

A reinforced mesh and composite technology, applied in the medical field, can solve the problems of not an ideal treatment method, limited autologous tissue donor area, etc.

Inactive Publication Date: 2015-07-15
ZHENDE MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the clinical effect of autologous tissue transplantation is good, the donor area of ​​autologous tissue is limited, and it is a method of "healing injury with injury". However, allogeneic or xenogeneic tissue transplantation is limited by immune rejection, which is not an ideal treatment method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of PGA reinforced net-collagen / chitosan composite support comprises the steps:

[0027] 1) Collagen and chitosan were formulated into 0.5% acetic acid solution with a mass fraction of 0.5%, and then the collagen solution and chitosan solution were mixed according to the volume ratio of 9:1, and then fully stirred to obtain a collagen / chitosan mixed solution ,spare;

[0028] 2) Polyglycolic acid (GA) is woven into a net after being melt-spun into a thread, and the net is cleaned with acetone, ultrasonically cleaned with pure water, and vacuum heat-set to obtain a PGA reinforced mesh. The vacuum heat-set temperature of the PGA reinforced mesh is 80 ℃;

[0029] 3) Cut the PGA reinforcement mesh into a size of 4.5cm×4.5cm, and lay it flat on the flat plate, and then press a “frame” mold with a thickness of 1cm and a size of 4cm×4cm tightly on the PGA reinforcement mesh, and then inject Step 1) The obtained collagen / chitosan solution is 3.2mL, so tha...

Embodiment 2

[0036] The preparation method of PGA reinforced net-collagen / chitosan composite support comprises the steps:

[0037]1) Collagen and chitosan were made into 0.5% acetic acid solution by mass fraction, and then the collagen solution and chitosan solution were mixed according to the volume ratio of 9:1, and then fully stirred to obtain a collagen / chitosan mixed solution ,spare;

[0038] 2) Polyglycolic acid (GA) is woven into a net after being melt-spun into a thread. The net is cleaned with acetone, purified water ultrasonic cleaning and vacuum heat setting to obtain a PGA reinforced net. The temperature for vacuum heat setting of the PGA reinforced net is 120°C ;

[0039] 3) Cut the PGA reinforcement mesh into a circle with a diameter of 2.0cm, then soak it in the prepared collagen / chitosan solution for 12 hours, take out the PGA reinforcement mesh and lay it flat on the flat mold, and put the excess PGA reinforcement mesh Gently scrape off the solution components, freeze to...

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Abstract

The invention discloses a composite support containing a PGA strengthening net, a preparation method and applications thereof. The support comprises at least one layer of PGA strengthening net and a collagen / chitosan porous support, which is casted on the PGA strengthening net; the pore size of the collagen / chitosan porous support is in a range of 30 to 500 [mu]m, the diameter of the net hole of the PGA strengthening net is in a range of 200 to 3000 [mu]m, and the diameter of single PGA wire is in a range of 10 to 200 [mu]m. The composite support prepared by the provided preparation method has the advantages of good biocompatibility, excellent mechanical properties, and specific three-dimensional porous structure, can be applied to constructions of organism and tissues, thus promotes the healing and filling of damaged tissues, and improves the healing quality.

Description

technical field [0001] The invention relates to a tissue engineering scaffold, in particular to a composite scaffold containing a PGA reinforcing net, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Tissue defect or organ failure caused by various injury factors is the enemy of human health. Taking the dermis as an example, the dermis is located between the epidermis and the subcutaneous tissue, and plays an important role in maintaining the elasticity and toughness of normal skin. Once the dermal tissue is severely damaged, it cannot regenerate. Clinically, a large number of scar formation and scar contracture in the later stage of simple autologous cut-thick skin transplantation and simple epidermal cell membrane transplantation also prove the important role of dermal tissue from another perspective. [0003] At present, there are three main ways to deal with tissue defects, namely: autologous ti...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/26A61L27/18
Inventor 韩春茂王新刚鲁建国胡修元有传刚
Owner ZHENDE MEDICAL CO LTD
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