Composite support containing PGA strengthening net, preparation method and applications thereof
A reinforced mesh and composite technology, applied in the medical field, can solve the problems of not an ideal treatment method, limited autologous tissue donor area, etc.
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Embodiment 1
[0026] The preparation method of PGA reinforced net-collagen / chitosan composite support comprises the steps:
[0027] 1) Collagen and chitosan were formulated into 0.5% acetic acid solution with a mass fraction of 0.5%, and then the collagen solution and chitosan solution were mixed according to the volume ratio of 9:1, and then fully stirred to obtain a collagen / chitosan mixed solution ,spare;
[0028] 2) Polyglycolic acid (GA) is woven into a net after being melt-spun into a thread, and the net is cleaned with acetone, ultrasonically cleaned with pure water, and vacuum heat-set to obtain a PGA reinforced mesh. The vacuum heat-set temperature of the PGA reinforced mesh is 80 ℃;
[0029] 3) Cut the PGA reinforcement mesh into a size of 4.5cm×4.5cm, and lay it flat on the flat plate, and then press a “frame” mold with a thickness of 1cm and a size of 4cm×4cm tightly on the PGA reinforcement mesh, and then inject Step 1) The obtained collagen / chitosan solution is 3.2mL, so tha...
Embodiment 2
[0036] The preparation method of PGA reinforced net-collagen / chitosan composite support comprises the steps:
[0037]1) Collagen and chitosan were made into 0.5% acetic acid solution by mass fraction, and then the collagen solution and chitosan solution were mixed according to the volume ratio of 9:1, and then fully stirred to obtain a collagen / chitosan mixed solution ,spare;
[0038] 2) Polyglycolic acid (GA) is woven into a net after being melt-spun into a thread. The net is cleaned with acetone, purified water ultrasonic cleaning and vacuum heat setting to obtain a PGA reinforced net. The temperature for vacuum heat setting of the PGA reinforced net is 120°C ;
[0039] 3) Cut the PGA reinforcement mesh into a circle with a diameter of 2.0cm, then soak it in the prepared collagen / chitosan solution for 12 hours, take out the PGA reinforcement mesh and lay it flat on the flat mold, and put the excess PGA reinforcement mesh Gently scrape off the solution components, freeze to...
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