Nevirapine pharmaceutical composition and preparation method thereof

Abstract

The invention discloses anti-AIDS (acquired immune deficiency syndrome) drug Nevirapine composition. The composition can improve gastrointestinal toxic and side effects and is characterized by comprising the following components: (i), a controlled release part which comprises the Nevirapine or other pharmaceutically acceptable derivatives and sustained release materials of the Nevirapine, wherein the sustained release materials contain chitosan and pectin and optionally contain other hydrophilic sustained release materials; (ii), an instant release part which contains at least a drug selected from famotidine or other pharmaceutically acceptable salt of the famotidine a well as a pharmaceutically acceptable carrier. The drug composition can be prepared into tablets or pills and can prevent or relieve adverse symptoms such as nausea, emesis or diarrhea and the like when a patient takes the anti-AIDS drug Nevirapine.

Description

technical field [0001] The invention relates to a nevirapine pharmaceutical composition, in particular to a nevirapine pharmaceutical composition capable of improving gastrointestinal toxicity, a preparation method and its use for treating AIDS. Background technique [0002] Acquired immunodeficiency syndrome (AIDS), commonly known as AIDS, caused by human immunodeficiency virus (human immunodeficiency virus, HIV) infection, is currently widespread worldwide and has become a major public health and social problem that has attracted worldwide attention. Now it is generally believed that HIV is the cause of AIDS and AIDS-related syndrome (AIDS-related complex, ARC). Not only is HIV the leading cause of AIDS, but HIV infection alone often causes over time such profound immunodeficiency that the patient dies. [0003] The "highly-active antiretroviral therapy (HAART)" proposed by Chinese American scientist He Dayi is recognized as a milestone in the treatment of AIDS. In the p...

AI Technical Summary

Problems solved by technology

Because the focus of this type of research is still to improve the rapid absorption of drugs, it does not specifically focus on how to avoid or reduce the damage of drug molecules such as nevirapine to the gastrointestinal mucosa. Therefore, although it has a good performance in promoting its drug utilization, However, it has little effect on reducing the toxic and side effects of drugs, especially reducing the damage caused by such drugs to the gastrointestinal mucosa after taking such drugs in patients with nausea, vomiting, diarrhea and other gastrointestinal syndromes

[0008] In addition, in the clinical process, some doctors have taken other adjuvant treatments for nourishing the stomach and protecting the stomach to relieve the pain of the patients, but this method increases the burden of medication, and it is only effective for gastrointestinal damage. After the repair, it is still difficult to change the various discomforts of the patients after taking the medicine, and it cannot prevent the disease.

[0009] At present, there are no relevant research reports on nevirapine anti-AIDS drugs that specifically aim at improving gastrointestinal side effects, preventing or alleviating corresponding gastrointestinal syndrome in patients during the course of taking them

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