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Long-circulating lipidosome as well as preparation method and application thereof

A long-circulating liposome, long-circulating technology, applied in the application, treatment of tobacco, tobacco and other directions, can solve problems such as poor stability

Inactive Publication Date: 2015-07-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional liposomes are thermodynamically unstable systems with poor stability

Method used

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  • Long-circulating lipidosome as well as preparation method and application thereof
  • Long-circulating lipidosome as well as preparation method and application thereof
  • Long-circulating lipidosome as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Long Circulating Liposomes Encapsulating Maltol

[0032] Materials and dosage:

[0033] Natural phospholipid material 200mg; Tween80 100mg; Maltol 50mg.

[0034] Preparation:

[0035] Weigh various materials according to the above dosage into a round bottom flask (250ml), add absolute ethanol in a water bath at 50°C until dissolved, remove the ethanol by rotary evaporation under reduced pressure, and form a thin film. Add PBS buffer solution, hydrate by rotary evaporation (50°C), cool rapidly, and sonicate in a crushed ice bath on a probe-type ultrasonic instrument for 4 minutes. After dissolving in water at 50°C for 2 hours, let it stand overnight at 4°C, remove titanium particles by refrigerated centrifugation, and fill with N 2 After sealing, the maltol-embedded long-circulation liposome is obtained. The obtained liposomes were freeze-dried to obtain liposome powder.

[0036] Such as figure 1 and figure 2 As shown, the obtained liposomes are analyzed and meas...

Embodiment 2

[0038] Long Circulating Liposomes Encapsulating β-Ionone

[0039] Materials and dosage: natural phospholipid material 200mg; Tween80 100mg; β-ionone 50mg.

[0040] Preparation:

[0041] Such as image 3 and Figure 4 As shown, various materials were weighed by the above-mentioned amount, and other operating procedures were the same as in Example 1. The obtained liposome is analyzed by a nanometer particle size distribution analyzer to determine that its particle diameter is about 110 nm, and the encapsulation efficiency is about 40%. Stability results showed that the long-circulating liposome remained stable at 25°C for at least 3 months, and remained stable at 25°C for at least 6 months after powderization, and had good storage stability.

Embodiment 3

[0043] Long Circulating Liposomes Encapsulating Rose Essential Oil

[0044] Materials and dosage: natural phospholipid material 200mg; Tween80 100mg; rose essential oil 50mg.

[0045] Such as Figure 5 and Figure 6 As shown, various materials were weighed by the above-mentioned amount, and other operating procedures were the same as in Example 1. The obtained liposomes were analyzed by a nanometer particle size distribution analyzer to determine that the particle size was about 100nm, and the encapsulation efficiency was about 10%. Stability results showed that the long-circulating liposome remained stable at 25°C for at least 3 months, and remained stable at 25°C for at least 6 months after powderization, and had good storage stability.

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Abstract

The invention discloses a long-circulating lipidosome as well as a preparation method and an application thereof. The long-circulating lipidosome is prepared by taking phospholipid as a lipidosome membrane material, and adding a membrane structure modifier and a long-circulating material. The lipidosome has a better embedding effect to flavor substances which have water solubility and oil solubility, and various water soluble ingredients and oil soluble flavor ingredients can be embedded at the same time; furthermore, the lipidosome is dried and then prepared into powder; meanwhile, the lipidosome is better in storage stability and is added into cigarettes, the stability of the long-circulating lipidosome can be kept in the storage process, and embedded core materials can be released when the cigarettes are smoked.

Description

technical field [0001] The invention relates to the technical field of liposome embedding, in particular to a long-circulation liposome and its application in cigarettes. Background technique [0002] Embedding preparations containing flavor substances are widely used in cigarettes, and these preparations can be added to shredded tobacco, cigarette paper, filter tip and tipping paper. At present, the embedding methods of aroma substances for tobacco mainly include composite coacervation method, β-cyclodextrin and maltodextrin adsorption method, and orifice-coagulation bath method. These methods are more suitable for embedding hydrophobic substances, but for flavor substances with certain hydrophilicity, the embedding yield is low and the storage stability is poor. There are relatively few methods suitable for embedding aqueous solutions and water-soluble components. The main methods are oil phase separation method and melting dispersion condensation method. The oil phase se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/26A24B15/18
CPCA24B15/26A24B15/18
Inventor 钟芳周志磊梁蓉李玥徐菲菲王一涵陈羚
Owner JIANGNAN UNIV
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