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Ginkgo dipyridolum composition, preparation thereof, preparation method of composition, and preparation method of preparation

A damole composition and the technology of the composition, applied in the field of medicine, can solve the problems of large clinical drug safety, low effective active ingredients, and large toxic and side effects, and achieve high drug bioavailability, good clinical curative effect, and effective activity The effect of high content of ingredients

Inactive Publication Date: 2015-07-29
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complexity of the active ingredients of Ginkgo biloba extract, the exploration of its medicinal active ingredients is not clear enough in the prior art. The Ginkgo Damole preparations currently on the market only control the content of total flavonoids, and do not control the ratio of effective active ingredients. control, so that the effective active ingredients are low, and the content of impurities such as ginkgolic acid and heavy metals in the preparations has not been effectively controlled, the safety and stability of the obtained pharmaceutical preparations are poor, the toxic and side effects are relatively large, and there are still great problems in the safety of clinical medication. risks of

Method used

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  • Ginkgo dipyridolum composition, preparation thereof, preparation method of composition, and preparation method of preparation
  • Ginkgo dipyridolum composition, preparation thereof, preparation method of composition, and preparation method of preparation

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Ginkgo Damo composition

[0023] Prescription: Quercetin 5.1g; Kaempferin 3.6g; Isorhamnetin 1.0g; Ginkgolide A1.4g; Ginkgolide B1.1g, Ginkgolide C1.0g; Ginkgolide M0.7g; Ginkgolide Ester 2.0g; Dipyridamole 3.2g.

[0024] Preparation method: accurately weigh the above raw materials, crush them, pass through a 100-mesh sieve, mix them thoroughly, add 95% ethanol to evenly wet them, and then put them in a percolator, add ethanol to the surface of the drug, and place it for 14 hours before infiltration Collect the percolate, recover the ethanol under low temperature and decompression, concentrate the medicinal solution to a thick paste, put it in a vacuum drying oven for 3 hours, and place it in a light-shielding container for airtight storage to obtain 18.2 g of the ginkgo damo composition.

Embodiment 2

[0025] Example 2: Ginkgo Damo composition

[0026] Prescription: Quercetin 5.5g; Kaempferin 4.2g; Isorhamnetin 1.3g; Ginkgolide A1.7g; Ginkgolide B1.2g, Ginkgolide C1.4g; Ginkgolide M1.0g; Ginkgolide Ester 2.3g; Dipyridamole 3.6g.

[0027] Preparation method: accurately weigh the above raw materials, pulverize, pass through a 100-mesh sieve, mix thoroughly, add 80% ethanol to evenly wet, and then put it into a percolator, add ethanol to the surface of the drug, and place it for 15 hours before infiltration Collect the percolate, recover the ethanol under low temperature and decompression, concentrate the medicinal solution to a thick paste, dry it in a vacuum drying oven for 2 hours, and place it in a light-shielding container for airtight storage to obtain 21.9 g of the ginkgo damo composition.

Embodiment 3

[0028] Example 3: Ginkgo Damo composition

[0029] Prescription: Quercetin 5.6g; Kaempferin 4.3g; Isorhamnetin 1.4g; Ginkgolide A1.8g; Ginkgolide B1.4g, Ginkgolide C1.5g; Ginkgolide M1.1g; Ginkgolide Ester 2.4g; Dipyridamole 3.7g.

[0030] Preparation method: accurately weigh the above raw materials, crush them, pass through a 100-mesh sieve, mix them thoroughly, add 90% ethanol to evenly wet them, and then put them in a percolator, add ethanol to the surface of the drug, and leave it for 12 hours for infiltration. The percolate is collected, the ethanol is recovered under low temperature and reduced pressure, the medicinal solution is concentrated to a thick paste, dried in a vacuum drying oven for 3 hours, and placed in a light-shielding container for airtight storage to obtain 22.4 g of the ginkgo damo composition.

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Abstract

The invention discloses a ginkgo dipyridolum composition, a preparation thereof, a preparation method of the composition, and a preparation method of the preparation. The ginkgo dipyridolum composition is prepared from ginkgo flavones components, ginkgolide components and dipyridamole, and is concretely prepared from the following components, by weight, 51-62 parts of quercetin, 36-50 parts of kaempferol, 10-17 parts of isorhamnetin, 14-22 parts of ginkgolide A, 11-16 parts of ginkgolide B, 10-20 parts of ginkgolide C, 7-15 parts of ginkgolide M, 20-28 parts of bilobalide and 32-42 parts of dipyridamole. In the ginkgo dipyridolum composition and the preparation thereof, the content of effective active components is high, and proportions of quercetin and other effective active components are controlled, so the medicine bioavailability is high in a specific proportion range, the cooperative treatment effect of all the effective components is best, the content of impurities is low, and good clinic curative effects are achieved.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition and a preparation and a preparation method thereof, in particular to a ginkgo biloba effective ingredient composition and a preparation and preparation method thereof. Background technique: [0002] Ginkgo biloba has the effects of improving cardiovascular and cerebrovascular circulation, improving memory, scavenging free radicals, and delaying aging. It has the dual effects of treatment and health care. The injection prepared from ginkgo biloba has been used clinically for many years and has achieved very good results. The composition of Ginkgo biloba extract is complex. The main active ingredients are total ginkgo flavonol glycosides and total ginkgo lactones. The total flavonol glycosides are mainly composed of ketone aglycones such as quercetin, kaempferol and isorhamnetin and monosaccharides such as glucose. Glycosides connected by oxyglycosidic bonds have the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P9/00A61P9/10A61P7/02A61K31/352A61K31/365
Inventor 窦啟玲
Owner GUIZHOU YIBAI PHARMA CO LTD
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