Device and method for realizing splitting of micro-droplets in micro-channel under assistance of surface acoustic waves

A surface acoustic wave and microchannel technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the complex design of focusing interdigital transducers, the difficulty of applying piezoelectric microfluidic systems, Lithium oxide substrate fragmentation and other problems, to achieve the effect of simple structure, transportation, and small size

Inactive Publication Date: 2015-07-29
CHANGZHOU INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since the micro-reactor requires high electrical signal power to break the digital micro-droplets on the PZT piezoelectric substrate, it is easy to break the lithium niobate substrate commonly used in the piezoelectric microfluidic system, and the focusing interdigitation is changed. The design of the energy device is more complicated, which brings difficulties to the application of the piezoelectric microfluidic system

Method used

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  • Device and method for realizing splitting of micro-droplets in micro-channel under assistance of surface acoustic waves
  • Device and method for realizing splitting of micro-droplets in micro-channel under assistance of surface acoustic waves

Examples

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Embodiment 1

[0034] A surface acoustic wave-assisted device for splitting micro-droplets in a microchannel proposed in this embodiment, as shown in the figure, includes a piezoelectric substrate 1 and a signal generating device 2 for generating RF electrical signals. The upper surface of the sheet 1 is the working surface, and the working surface of the piezoelectric substrate 1 is provided with microchannels 3 for transporting digital micro-droplets 9, which are respectively connected with the signal generating device 2 and are used to excite the splitting of the surface acoustic wave. Unweighted IDT 4 and non-split unweighted IDT 5, a first reflective grating 6 for reducing the power of the RF electrical signal loaded on the split unweighted IDT 4, The second reflection grid 7 for reducing the power of the RF electrical signal loaded on the unweighted interdigital transducer 5 for splitting, the unweighted interdigital transducer 4 for splitting, and the unweighted interdigital transducer...

Embodiment 2

[0041] This embodiment proposes a method corresponding to the device for assisting the splitting of micro-droplets in a microchannel given in Embodiment 1, which includes the following steps:

[0042] ①Connect the signal generator and power amplifier of the signal generating device, connect the power amplifier and switch, connect the bus bar and the first lead pin of the unweighted IDT for splitting, and connect the unweighted IDT for non-split of the bus bar with the second lead pin.

[0043] ② Place the digital micro-droplet to be split in the front part of the microchannel, and make the digital micro-droplet to be split on the acoustic transmission path of the surface acoustic wave excited by the unweighted interdigital transducer for splitting.

[0044] ③ Make the switch connect the power amplifier and the first lead pin, start the signal generator and the power amplifier, and utilize the existing sample injector to inject the sample immiscible with the aqueous phase fluid...

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Abstract

The invention discloses a device and a method for realizing splitting of micro-droplets in a micro-channel under the assistance of surface acoustic waves. The device comprises a piezoelectric substrate and a signal generator, wherein the micro-channel as well as a splitting unweighted interdigital transducer and a non-splitting unweighted interdigital transducer which are connected with the signal generator respectively are arranged on a working surface of the piezoelectric substrate, the two interdigital transducers are symmetrically distributed on two transverse sides of the front of the micro-channel, a flow blocking strip with the width smaller than that of the micro-channel is arranged in the front end of the back of the micro-channel, a sub-channel for conveying unsplit digital micro-droplets is formed by space between the second transverse outer side surface of the flow blocking strip and the second transverse inner side surface of the front end of the back of the micro-channel, the sub-channel is close to one side of the splitting unweighted interdigital transducer, and a plurality of mini-channels for splitting the digital micro-droplets are formed in the flow blocking strip. The device and the method have the advantages that the digital micro-droplets can be split by the aid of lower electric signal power, and the piezoelectric substrate can be well prevented from being broken.

Description

technical field [0001] The invention relates to a micro-droplet splitting technology in a micro-channel in a microfluidic chip, in particular to a device and a method for realizing micro-droplet splitting in a micro-channel assisted by surface acoustic waves. Background technique [0002] Microfluidic technology can integrate a series of sampling, sample pretreatment, separation, reaction, detection and data analysis on a microfluidic substrate, which greatly reduces the cost of microfluidic analysis and shortens the time of microfluidic analysis. Therefore, Microfluidic chips with microfluidic technology as the core have been widely used in DNA sequencing, protein analysis, single cell analysis, drug detection and food safety and other fields. According to the form of microfluids in the microfluidic analysis system, microfluidics can be divided into continuous microfluidics in the form of continuous flow and digital microdroplets in the form of discrete microdroplets. Gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01J19/10
Inventor 章安良张小权胡文艳陈森陆雨枫张晴雯
Owner CHANGZHOU INST OF TECH
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