Preparation method of moxidectin

Abstract

The invention discloses a preparation method of moxidectin. The preparation method comprises the following steps: 1) inoculating a strain in a strain culture medium for culture to obtain spore suspension M1; 2) inoculating the spore suspension M1 in a seed culture medium for culture to obtain seed solution M2; 3) inoculating the seed solution M2 in a fermentation culture medium for culture to obtain primary extract solution M3; 4) performing protection reaction, oxidation reaction, deprotection reaction and oximation reaction to the primary extract solution M3 to obtain the moxidectin, wherein the strain is Streptomyces cyaneogriseus and / or Streptomyces hygroscopicus. By adopting the method, the total yield of the prepared moxidectin is enabled to be obviously higher and thus the effects of simpler and more convenient production manner and higher yield are realized.

Description

technical field

[0001] The invention relates to the field of production and preparation of moxidectin, in particular to a preparation method of moxidectin. Background technique

[0002] Moxidectin is a new type of antiparasitic drug, a single-component macrolide antibiotic fermented by Streptomyces. As an antiparasitic drug, it is widely used in basic agriculture such as animal husbandry and aquaculture, and with the development of agriculture and other fields, the international demand for antiparasitic drugs has continued to grow. At present, the annual market demand for this product is about 10 tons, and the market size exceeds 200 million US dollars.

[0003] From the 1970s to the 1980s, my country had synthetically produced drugs such as hexachloro-p-xylene, nitrothiocyanamide, thiobisdichlorophene, and niclosamide, which effectively prevented and controlled livestock parasitic diseases that commonly occurred in my country. Since the 1990s, my country has carried out r...