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Stomach-recovering pellet as well as preparation method and application thereof

A technology of Weikangling micropills and Baiji, which is applied in the field of Weikangling micropills and its preparation, can solve problems such as poor taste, and achieve the effects of good fluidity, high content of active ingredients, and high dissolution rate

Active Publication Date: 2015-08-26
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The capsule granules prepared by this method have better fluidity, less difference in filling capacity, and are convenient for filling capsules. However, there are certain problems in the stability of the product, and poor taste will appear after storage for a period of time.

Method used

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  • Stomach-recovering pellet as well as preparation method and application thereof
  • Stomach-recovering pellet as well as preparation method and application thereof
  • Stomach-recovering pellet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 Weikangling Capsules

[0031] Radix Paeoniae Alba 317.5g, Baiji 238g, Radix Notoginseng 9.92g, Licorice 317.5g, Poria 238g, Corydalis Corydalis 158.7g, Cuttlefish octopus 31.7g, Belladonna extract 2.06g, β-cyclodextrin 8g.

[0032] Preparation:

[0033] (1) Nano-grinding Baiji, Panax notoginseng, and sea octopus, passing through a 200-mesh sieve, and mixing to obtain nano-powder;

[0034] (2) At a temperature of 90°C, licorice is dynamically extracted with water 10 times the weight of the medicinal material, the control speed is 60 rpm, and after 4 hours, it is filtered, ultracentrifuged and concentrated under low pressure (vacuum degree -0.075MPa, temperature at 65°C, the relative density of the concentrate is 1.08g / cm 3 ) to obtain the first concentrated solution; then at a temperature of 80°C, dynamically extract Radix Paeoniae Alba, Corydalis Corydalis and Poria Cocos with water 12 times the weight of the medicinal materials, control the rotation spee...

Embodiment 2

[0038] Embodiment 2 Weikangling Granules

[0039] Radix Paeoniae Alba 317.5g, Baiji 238g, Panax notoginseng 9.92g, Licorice 317.5g, Poria cocos 238g, Corydalis 158.7g, Cuttlefish octopus 31.7g, Belladonna extract 2.06g, β-cyclodextrin 8g, dextrin 12g, malt Dextrin 4g, stevia 5g.

[0040] Preparation:

[0041] (1) Nano-grinding Baiji, Panax notoginseng, and sea octopus, passing through a 200-mesh sieve, and mixing to obtain nano-powder;

[0042] (2) At a temperature of 90°C, licorice is dynamically extracted with water 10 times the weight of the medicinal material, the control speed is 60 rpm, and after 4 hours, it is filtered, ultracentrifuged and concentrated under low pressure (vacuum degree -0.075MPa, temperature 65°C, the relative density of the concentrated solution is 1.08), to obtain the first concentrated solution; then at a temperature of 80°C, dynamically extract Radix Paeoniae Alba, Corydalis Corydalis and Poria cocos with water 12 times the weight of the medicina...

Embodiment 3

[0046] Embodiment 3 Weikangling tablet

[0047] Radix Paeoniae Alba 317.5g, Baiji 238g, Panax notoginseng 9.92g, Licorice 317.5g, Poria cocos 238g, Corydalis 158.7g, Cuttlefish octopus 31.7g, Belladonna extract 2.06g, β-cyclodextrin 8g, Microcrystalline cellulose 20g .

[0048] Preparation:

[0049] (1) Nano-grinding Baiji, Panax notoginseng, and sea octopus, passing through a 200-mesh sieve, and mixing to obtain nano-powder;

[0050] (2) At a temperature of 90°C, licorice is dynamically extracted with water 10 times the weight of the medicinal material, the control speed is 60 rpm, and after 4 hours, it is filtered, ultracentrifuged and concentrated under low pressure (vacuum degree -0.075MPa, temperature 65°C, the relative density of the concentrated solution is 1.08), to obtain the first concentrated solution; then at a temperature of 80°C, dynamically extract Radix Paeoniae Alba, Corydalis Corydalis and Poria cocos with water 12 times the weight of the medicinal material...

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Abstract

The invention discloses a stomach-recovering pellet as well as a preparation method and application thereof. The stomach-recovering pellet is prepared from the following raw materials in parts by weight: 300-350 parts of white peony root, 200-250 parts of rhizoma bletillae, 5-15 parts of pseudo-ginseng, 300-350 parts of licorice, 200-250 parts of tuckahoe, 150-200 parts of rhizoma corydalis, 20-50 parts of cuttlebone, 1-5 parts of a belladonna extract, and 5-20 parts of beta-cyclodextrin. According to the stomach-recovering pellet and the preparation method thereof disclosed by the invention, rhizoma bletillae, pseudo-ginseng and cuttlebone are processed by a nanometer crushing method, and the obtained nanometer medicinal powder is directly used for preparing the medicine, so that the preparation method is simple and convenient to operate; the obtained medicinal powder is good in mobility; the raw materials are cooked by a dynamic stirring manner, and the revolving speed of the dynamic stirring is strictly controlled, so that the stability can be improved, the impurities separated out can be reduced; the stomach-recovering pellet prepared by the preparation method is high in content of effective elements; the differential items meet the requirements; the preparation method further saves the water consumption, and the repeated extraction in the extraction process can be avoided.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Weikangling pellet and a preparation method thereof. Background technique [0002] Peptic ulcer is a chronic disease that occurs in the stomach and duodenum, and is a common and frequently-occurring disease in clinical practice. With the improvement of people's living standards, significant changes have taken place in living habits, eating habits, mental stress, and psychological factors, leading to an obvious upward trend in the incidence of peptic ulcer. [0003] Weikangling is a commonly used gastrointestinal medicine, which has the functions of softening the liver and harmonizing the stomach, dispelling blood stasis and stopping bleeding, and removing saprophysis. It is mainly used to treat spleen-stomach disharmony, epigastric pain, joints and flanks, belching, and acid deficiency caused by chronic superficial gastritis; acute and chronic gastritis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/16A61P1/04A61P1/00A61K35/618
Inventor 刘景萍刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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