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Absorbable bone fixation material and preparation method thereof

A technology for fixing materials and absorbing materials, which is applied in medical science, surgery, coating, etc., and can solve the problems of low strength of polymer materials, limiting the application of polymer materials, and the influence of organisms

Inactive Publication Date: 2015-08-26
CHF SHANGHAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, compared with metal materials, polymer materials tend to have lower strength and larger deformation, which limits the application of polymer materials in the field of bone fixation.
CN103330959A discloses a composite fixing material of magnesium alloy and polylactic acid. The metal / polymer material combines the advantages of metal and polymer materials, but a part of hydrogen gas will inevitably be released during its degradation process, causing damage to organisms. influences
CN103467938A discloses a degradable medical resin composition, which can improve the mechanical properties of the blend to a certain extent, but due to the uncontrollability of each component material during the blending process, the degradation performance of the blend is difficult to control
US2006 / 0247638A1 discloses a spinal fixation material system, which contains at least one metal material in order to ensure mechanical properties, and cannot be completely degraded and absorbed

Method used

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  • Absorbable bone fixation material and preparation method thereof
  • Absorbable bone fixation material and preparation method thereof
  • Absorbable bone fixation material and preparation method thereof

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preparation example Construction

[0075] The preparation method of bioabsorbable bone fixation material of the present invention may comprise the following steps:

[0076] (1) providing the wire for preparing the core part,

[0077] (2) Extrude and melt-coat the material for preparing the shell onto the wire rod in step (1), thereby preparing the bioabsorbable bone fixation material of the present invention.

[0078] Generally, the wire used as the core of the present invention can be prepared by extruding the polymer material for the core through a twin-screw extruder. The diameter of the wire can be controlled by controlling parameters such as extrusion speed. Extruded strands can be drawn to impart high strength and low elastic deformation. Usually, the stretching process includes high-magnification and low-speed stretching, wherein the stretching ratio is usually 4-8 times, and the stretching speed is usually 20-50 m / min. As mentioned above, the tensile strength of each wire rod in the core part of the ...

Embodiment 1

[0089] Dry polyglycolic acid slices with a weight-average molecular weight of 100,000 in a vacuum oven for 48 hours, and then extrude them in a twin-screw extruder at a screw temperature of 200-255°C. The size is controlled by the extruder head to obtain a diameter of 0.30 The wire rod of mm is subjected to high-magnification and low-speed stretching (stretch ratio 4.6, stretching speed 30m / min) drafting treatment, so that the wire rod has higher strength and lower elastic deformation, thereby preparing the core material.

[0090] The polycaprolactone slices with a weight average molecular weight of 25,000 were dried in a vacuum oven for 48 hours, and then extruded in a twin-screw extruder at a screw temperature of 60-100°C to extrude the shell material.

[0091] After passing the above-mentioned wires through the transverse coating machine head, the shell material is melted and coated on the surface of the inner core wires to make a material with a diameter of 0.36 mm in the c...

Embodiment 2

[0095] Dry polylactic acid slices with a weight average molecular weight of 150,000 in a vacuum drying oven for 48 hours, and then extrude them in a twin-screw extruder at a screw temperature of 150-255°C. The size is controlled by the extruder head to obtain a diameter of 0.40mm The wire rod is then stretched at a high rate and low speed (drawing ratio 5.2, stretching speed 32m / min), so that the wire rod has higher strength and lower elastic deformation, and the core material is obtained.

[0096] The polycaprolactone chips with a weight average molecular weight of 43000 were dried in a vacuum drying oven for 48 hours, and then extruded in a twin-screw extruder at a screw temperature of 60-100°C to extrude the shell material.

[0097] After passing the above-mentioned wires through the transverse coating machine head, the shell material is melted and coated on the surface of the inner core wires to make a material with a diameter of 0.50 mm in the core-shell structure.

[009...

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Abstract

The invention relates to a biologically absorbable bone fixation material and a preparation method thereof. The absorbable bone fixation material comprises a core part and a shell part coating the core, wherein the core and the shell are made of a biologically absorbable material. The preparation method comprises the steps of providing a wire material preparing the core part; extruding the material for preparing the shell and coating the extruded material on the wire material through fusion. The biologically absorbable bone fixation material disclosed by the invention is high in mechanical strength, and the absorption time can be effectively controlled.

Description

technical field [0001] The invention belongs to the field of absorbable bone fixation materials, in particular to an absorbable bone fixation material and a preparation method thereof. Background technique [0002] Most of the currently widely used fracture fixation materials are metal materials, such as stainless steel, titanium alloy, and the like. Metal fracture fixation materials have good strength, rigidity and biocompatibility. [0003] However, metal materials are generally not bioabsorbable. After the fracture site heals, it needs to be removed by a second operation, which not only costs a lot, but also brings secondary pain to the patient. At the same time, metal materials will also affect medical examinations such as CT or MRI after surgery, causing inconvenience. [0004] Polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL) and other materials are polyester polymer materials with excellent biocompatibility and bioabsorbability, and are widely u...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/10A61L31/14
Inventor 汪元璋杨卫国廖申扬夏哲安朱弘侃龚峰江渊陆慧丽
Owner CHF SHANGHAI PHARMA