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Method for preparing anti-adhesive membrane for tendon ligaments

An anti-adhesion film and tendon technology, applied in the field of medical materials, can solve problems such as uncontrollable absorption time, secondary damage to the body, unsatisfactory effect, etc., and achieve the effects of relieving pain, promoting repair, and preventing exogenous healing

Inactive Publication Date: 2011-06-01
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If it is not easy to absorb or permanent foreign matter, the effect is not ideal
Biological materials, such as: artificial skin, fat tissue, autogenous tendon, etc., some of which cause secondary damage to the body, and some cannot control the absorption time

Method used

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  • Method for preparing anti-adhesive membrane for tendon ligaments

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation method of tendon and ligament anti-adhesion film of the present invention comprises the following steps:

[0021] 1. Slurry Preparation

[0022] 1.1 Raw material thawing:

[0023] The collagen is taken out from the freezer, and the usage amount of the batch is calculated according to the water content, placed in a sterilized plate, and used after thawing at room temperature.

[0024] 1.2 Preparation calculation method

[0025] 600ml acid solution contains 3-5g dry collagen

[0026] 1. Preparation of 30.05M glacial acetic acid:

[0027] Take 2-6ml of glacial acetic acid to a 1000ml Erlenmeyer flask, add sterile water to 720ml, stir with a magnetic stirrer for 10 minutes, and measure the pH to be 2.5-5.0.

[0028] 1.4 Preparation of chondroitin sulfate sodium salt:

[0029] Add 0.2-0.6g chondroitin sulfate sodium salt to 120ml of 0.05M glacial acetic acid, stir with a magnetic stirrer for 20-50 minutes, set it to dissolve completely (no visible insolu...

experiment example

[0071] Adopt the method for embodiment 1 to prepare a plurality of products, adopt electron microscope to measure the pore size in its structure, the result is as shown in the table below:

[0072] It can be seen from the above test examples that the tendon and ligament anti-adhesion film prepared by the present invention has a specific three-dimensional pore structure, and the pore size is basically about 200-220 μm.

[0073] In the embodiment of the present invention, the type I collagen and chondroitin sulfate are mixed and stirred in a certain concentration of acid water to form a slurry, and then a degradable collagen sponge film with specific pores is made under a freeze-drying process, and then temperature cross-linked. Package. The product has the advantages of absorbability, antigen-free, and suture-free. It can effectively prevent or reduce the formation of adhesions and promote the repair of damaged tendons.

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Abstract

The invention discloses a method for preparing an anti-adhesive membrane for tendon ligaments. In the method, the anti-adhesive membrane is prepared by freeze-drying slurry formed by stirring type I collagen and chondroitin sulfate in acid water with certain concentration. The invention has the advantages that the anti-adhesive membrane can be absorbed, has no antigen, is free from suturing and the like, and can prevent or reduce the formation of adhesion effectively and promote to rehabilitate injured tendons.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a tendon and ligament anti-adhesion film. Background technique [0002] The formation of adhesions during the repair of tendon injuries has always been a major problem in hand surgery, trauma, and orthopedics. If there is adhesion, a second release operation is required. The second release operation will cause new trauma and bring pain to the patient. . Therefore, how to minimize the formation of adhesions after tendon injury and avoid secondary release operations has been perplexing doctors and researchers for many years. [0003] Material scientists and doctors try to solve this problem by applying various materials and methods. Non-biological materials, such as: polymer cellulose, glycerol mixture (GM), sodium hyaluronate (SH), poly-DL-lactic acid (PDLLA), gold foil, etc., but there are different shortcomings. If it is not easy to absorb or permanent ...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/24A61L27/20A61L31/04A61L31/14
Inventor 康承桂睢银海
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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