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Method for preparing biological activity glass microspheres by macroporous carbon template

A bioactive glass and macroporous carbon technology, applied in the field of biomedical materials, can solve the problems of difficult dispersion of particles, difficult to control micro-nano structure, difficult to control the size of morphological particles, and difficult to exert the micro-nano effect of materials, and achieves uniform particle size, The effect of small particle size deviation and good biological activity

Inactive Publication Date: 2015-08-26
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biggest problem with sol-gel bioglass is that the particles are difficult to disperse, and its micro-nano structure, shape, and particle size are difficult to control, so that the micro-nano effect of the material is difficult to exert

Method used

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  • Method for preparing biological activity glass microspheres by macroporous carbon template
  • Method for preparing biological activity glass microspheres by macroporous carbon template
  • Method for preparing biological activity glass microspheres by macroporous carbon template

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1（58

[0023] 1. Implementation case 1 (58S does not require sodium source)

[0024] 1. Preparation of 58S bioactive glass microspheres with different particle sizes:

[0025] (1) Stir 9.375g tetraethyl orthosilicate, 1.0875g triethyl phosphate, 7.5g absolute ethanol, 0.3g nitric acid solution (2mol / L), and 0.75g distilled water in a 50mL beaker for 2h.

[0026] (2) Add 6.375g calcium nitrate tetrahydrate to the above mixture, stir until completely dissolved.

[0027] (3) Four copies of the above solution were prepared in parallel.

[0028] (4) Immerse three-dimensionally ordered macroporous carbon templates with pore diameters of 470 nm, 350 nm, 250 nm, and 180 nm, respectively, and soak overnight.

[0029] (5) Place the 4 samples in an oven at 60°C and gel for 3 days until completely dry.

[0030] (6) Remove excess gel on the surface of the template, calcinate in a high-temperature furnace at 600°C for 3 hours, grind and ultrasonically disperse to obtain 4 parts of 58S (58% SiO ...

Embodiment example 2（68

[0044] 2. Implementation case 2 (68S does not require sodium source)

[0045] 1. Preparation of 68S bioactive glass microspheres with different particle sizes:

[0046] (1) Stir 12.23g tetraethyl orthosilicate, 1.145g triethyl phosphate, 7.5g absolute ethanol, 0.3g nitric acid solution (2mol / L), and 0.75g distilled water in a 50mL beaker for 2h.

[0047] (2) Add 4.825g calcium nitrate tetrahydrate and stir until completely dissolved.

[0048] (3) Four copies of the above solution were prepared in parallel.

[0049] (4) Immerse three-dimensionally ordered macroporous carbon templates with pore diameters of 470 nm, 350 nm, 250 nm, and 180 nm, respectively, and soak overnight.

[0050] (5) Place in an oven at 60°C for 3 days to gel until completely dry.

[0051] (6) Remove excess gel on the surface of the template, calcinate in a high-temperature furnace at 600°C for 3 hours, grind and ultrasonically disperse to obtain 68S (68%SiO 2 -23%CaO-9%P 2 o 5 , wt%) bioactive glass ...

Embodiment example 3

[0056] 1. Preparation of 45S5 bioactive glass microspheres with different particle sizes:

[0057] (1) Stir 7.812g tetraethyl orthosilicate, 0.774g triethyl phosphate, 0.8g nitric acid solution (2mol / L), and 12.15g distilled water in a 50mL beaker for 2h.

[0058] (2) Add 5.0182g of calcium chloride and 3.4g of sodium nitrate, and stir until completely dissolved.

[0059] (3) Four copies of the above solution were prepared in parallel.

[0060] (4) Immerse three-dimensionally ordered macroporous carbon templates with pore diameters of 470 nm, 350 nm, 250 nm, and 180 nm, respectively, and soak overnight.

[0061] (5) Place in an oven at 60°C for 3 days to gel until completely dry.

[0062] (6) Remove the excess gel on the surface of the template, calcinate in a high-temperature furnace at 600 °C for 3 h, grind and ultrasonically disperse to obtain 45S5 (46.1% SiO 2 -26.9%CaO-24.4%Na 2 O-2.6%P 2 o 5 , wt%) bioactive glass microsphere powder.

[0063] 2. The biological act...

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Abstract

The invention discloses a method for preparing biological activity glass microspheres by a macroporous carbon template and relates to the technical field of biomedical materials. A silicon source, a phosphorus source and a calcium source are used as raw materials, and three-dimensional ordered macroporous carbon is used as a template to synthesize several submicron-sized biological activity glass microspheres. The obtained biological activity glass microspheres have the advantages that the biological activity and the biological degradability are good, components are adjustable, the grain diameter is uniform, the dispersibility is good, and the like.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of submicron bioactive glass microspheres. Background technique [0002] Sub-micron biomaterials are an important part and development direction of research in the field of materials and medicine today, and sub-micron materials may become the core of biomedical materials in the 21st century. Bioactive glasses (Bioglasses, BGs) are the second generation of degradable biomaterials invented by Professor Larry L. Hench of the University of Florida in the early 1970s. They found that the components were divided into SiO 2 -Na 2 O-CaO-P 2 o 5 After the glass material is implanted in the organism, the components in the glass material can exchange or react with the components in the organism to form a strong chemical bond, and finally generate a substance compatible with the organism itself to form new bones and teeth. a part of. This kind of bi...

Claims

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Application Information

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IPC IPC(8): C03C12/00
Inventor 纪立军黄凯
Owner YANGZHOU UNIV
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