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Ferritin-based monofunctionalized magnetic nanometer particle

A magnetic nanoparticle, monofunctional technology, applied in the direction of chemical instruments and methods, peptides, peptides, etc., to achieve the effect of easy transformation, convenient mass acquisition, and easy manipulation

Active Publication Date: 2015-08-26
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Problems solved by technology

However, obtaining asymmetric magnetic nanoparticles, controlling their self-assembly at the molecular level, and accurately analyzing their assembly products are still challenging work.

Method used

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  • Ferritin-based monofunctionalized magnetic nanometer particle
  • Ferritin-based monofunctionalized magnetic nanometer particle
  • Ferritin-based monofunctionalized magnetic nanometer particle

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preparation example Construction

[0024] Specifically, the preparation method includes the following steps:

[0025] 1) Genetic modification of the starvation-induced DNA-binding protein to construct a protein mutant vector with functional groups and separation groups;

[0026] 2) Transform the constructed vector into the organism for expression, purify and identify starvation-induced DNA-binding protein mutants;

[0027] 3) Fully mix the mutant with wild-type ferritin, and then perform protein depolymerization and mixed assembly under pH-adjusted conditions;

[0028] 4) Purify the assembly product according to the characteristics of the separation group;

[0029] 5) Mineralize the obtained asymmetric functionalized nanoparticles, and synthesize iron oxide magnetic nanoparticles in the particle center. The single-bonded magnetic nanoparticles of the target product are obtained.

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Abstract

The invention discloses ferritin-based monofunctionalized magnetic nanometer particle. The ferritin-based monofunctionalized magnetic nanometer particle comprises a monofunctionalized ferritin shell and a magnetic nanometer particle core. The monofunctionalized ferritin shell is an asymmetric globulin with a tetrahedral structure. The asymmetric globulin mainly comprises one mutant Dps subunit and eleven wild Dps subunits. The Dps is a starvation-induced DNA binding protein. The ferritin-based monofunctionalized magnetic nanometer particle is prepared from biomacromolecule-protein as a template material, can be reconstructed easily, can be operated conveniently, is convenient for large-scale acquisition, has only one functional group and has an important meaning for follow-up controllable assembling.

Description

technical field [0001] The invention specifically relates to a ferritin-based monofunctional magnetic nanoparticle, which belongs to the field of nanobiotechnology. Background technique [0002] Magnetic nanoparticles are an important part of nanomaterials. Because of their special size distribution, magnetic nanoparticles have surface and interface effects, small size effects, quantum size effects, macroscopic quantum tunneling, etc., so they are widely used, involving machinery, electronics, etc. , optics, magnetism, chemistry and biology and other fields. A necessary condition for the application of magnetic nanoparticles in nuclear magnetic resonance imaging, magnetic separation, drug delivery carriers, and tumor hyperthermia is good superparamagnetism. Although the unmodified one has good superparamagnetism, due to the small particle size, large specific surface area and the influence of van der Waals force, the particles themselves are easy to aggregate and have poor ...

Claims

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Application Information

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IPC IPC(8): C07K14/00
Inventor 王强斌马灵芝
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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