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Massage ointment for activating blood circulation to remove blood stases and regulating collateral to relieve pain and preparation method thereof

A technology for promoting blood circulation and removing blood stasis and ointment, applied in the field of medicine, can solve the problems of poor particle size distribution uniformity, large particle size of cream, cold resistance and heat resistance oil-water separation, etc., and achieves strong process operability and particle size distribution. Uniform, high transdermal absorption effect

Active Publication Date: 2015-09-09
SHINEWAY PHARMA GRP SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The characteristic of this pharmacopoeia method is that after mixing the raw and auxiliary materials, add the traditional Chinese medicine extract, add water, heat, stir, and emulsify. Sexual oil-water separation phenomenon, and centrifugal test layering phenomenon, the yield of the product needs to be improved
In addition, the particle size of the cream prepared by this method is relatively large, and the uniformity of the particle size distribution is poor, which affects the transdermal absorption of the drug, and the massage ointment cannot fully exert the drug effect.

Method used

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  • Massage ointment for activating blood circulation to remove blood stases and regulating collateral to relieve pain and preparation method thereof
  • Massage ointment for activating blood circulation to remove blood stases and regulating collateral to relieve pain and preparation method thereof
  • Massage ointment for activating blood circulation to remove blood stases and regulating collateral to relieve pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027]

[0028] The preparation method of massage ointment comprises: (1) preparation of Chinese medicine extract: get frankincense, myrrh, black medicine, chuanxiong, turmeric decoction pieces, add 50% ethanol of 5 times the amount of decoction pieces, soak and extract 5 times, each time After 10 days, combine the extracts, add rue extract and belladonna liquid extract, stir well, filter, and adjust the relative density of the filtrate to 0.80 at 20°C for later use; (2) prepare the oil phase: mix stearic acid, mono Glyceryl stearate, stearyl alcohol, methyl salicylate, peppermint oil, camphor, cinnamon oil, and clove oil were heated and mixed, and kept at 70°C for later use; (3) Preparation of the water phase: water, glycerin, dodecane Sodium sulfate and triethanolamine are heated and mixed, and kept at 70°C for later use; (4) phase combination: add the water phase to the oil phase under stirring (speed 100-140r / min), and keep the temperature at 80-85°C during t...

Embodiment 2

[0039]

[0040]

[0041] The preparation method of the massage ointment comprises: (1) preparation of traditional Chinese medicine extract: take frankincense, myrrh, black medicine, chuanxiong, turmeric decoction pieces, add 2 times the amount of 80% ethanol of the decoction pieces, soak and extract 2 times, each 5 day, combine the extracts, add rue extract, belladonna liquid extract, stir evenly, filter, and when the filtrate is adjusted to 20 ℃, the relative density is 0.83 for later use; (2) prepare the oil phase: stearic acid, monohard Fatty acid glyceride, stearyl alcohol, methyl salicylate, peppermint oil, camphor, cinnamon oil, clove oil are heated and mixed, and kept at 80°C for later use; (3) Preparation of the water phase: water, glycerin, lauryl Sodium sulfate and triethanolamine are heated and mixed, and kept at 80°C for later use; (4) phase combination: the water phase is added to the oil phase under stirring conditions (speed 100-140r / min), and the temperatu...

Embodiment 3

[0052]

[0053]

[0054] The preparation method of massage ointment comprises: (1) preparation of traditional Chinese medicine extract: get frankincense, myrrh, black medicine, chuanxiong, turmeric decoction pieces, add 1 times the amount of 90% ethanol of the decoction pieces, soak and extract 3 times, each 3 day, combine the extracts, add rue extract, belladonna liquid extract, stir well, filter, and the relative density of the filtrate is adjusted to 20 ℃ to be 0.87 for later use; (2) prepare the oil phase: stearic acid, monohard Fatty acid glyceride, stearyl alcohol, methyl salicylate, peppermint oil, camphor, cinnamon oil, clove oil are heated and mixed, and kept at 90°C for later use; (3) Preparation of the water phase: water, glycerin, lauryl Sodium sulfate and triethanolamine are heated and mixed, and kept at 90°C for later use; (4) phase combination: the water phase is added to the oil phase under stirring conditions (speed 100-140r / min), and the temperature is k...

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Abstract

The invention relates to a massage ointment for activating blood circulation to remove blood stases and regulating collaterals to relieve pain and a preparation method thereof. The massage ointment is prepared from twelve traditional Chinese medicines of a common rue herb extract, a belladonna liquid extract, frankincense, myrrh, combined spicebush root, szechuan lovage rhizome, turmeric root-tuber, menthyl salicylate, peppermint oil, cinnamon oil, clove oil and camphor, and the preparation method mainly comprises the following steps: (1) preparing a traditional Chinese medicine extract, (2) preparing an oil phase, (3) preparing a water phase, and (4) combining the phases. The massage ointment provided by the invention has the characteristics of being relatively small in emulsion particle size, uniform in particle size distribution, relatively high in percutaneous absorption rate and more sufficient in drug effect exertion. The preparation method of the massage ointment provided by the invention has the characteristics of high process operability, good product reproducibility and high rate of finished products.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a massage ointment for promoting blood circulation, removing blood stasis, harmonizing collaterals and relieving pain and a preparation method thereof. Background technique [0002] The cream is an external semi-solid preparation that is easy to spread on the wound surface of the skin by adding the drug into a suitable matrix. There are three types of bases commonly used in ointments: oily bases, emulsion bases, and water-soluble bases. Ointments made with an emulsion-type base are called creams. The emulsion base refers to the semi-solid emulsion base formed by the oil phase and the water phase through the action of an emulsifier, which can be divided into water-in-oil type (W / O) and oil-in-water type (O / W). "The Pharmacopoeia of the People's Republic of China" 2010 Edition First Supplement records a massage ointment (massage cream), which is an oil-in-water (O / W) cream that has the fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/06A61P29/00A61K31/618A61K31/125
Inventor 倪永良杨宝翠刘铁军程翠娜王亚涛牛梵姜永军李春花李哲李雅雯王俊关秀伟
Owner SHINEWAY PHARMA GRP SHANDONG
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