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A kind of synthetic method that general formula is the bromine-containing ester of ch3cxbrcoor

A synthesis method and technology of the general formula are applied in the synthesis field of bromine-containing esters, can solve the problems of waste of raw materials, high price and high product cost, and achieve the effects of high conversion rate and selectivity, fast reaction speed and low reaction cost.

Active Publication Date: 2018-08-28
JUHUA GROUP TECH CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And well-known, "the brominating agent with nitrogen-bromine bond" is expensive, and usage is big, therefore causes product cost height, and this method economic benefit is poor, is unfavorable for suitability for industrialized production
And adopting this method to prepare 2-fluoro-2-bromoacrylate, the conversion rate is low, and it is easy to cause waste of raw materials; the reaction cycle is long, increasing time cost, and is also unfavorable for industrialized production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Add 10.6g (0.1mol) methyl 2-fluoropropionate, 150g carbon tetrachloride, 16.0g (0.1mol) bromine, 16.2g (0.12mol) sulfuryl chloride, 0.3g Azoisobutyronitrile was stirred and heated to 70°C for reaction. After 8 hours, the conversion rate of methyl 2-fluoropropionate was 96.2%, and the selectivity of methyl 2-fluoro-2-bromopropionate was 90.2%.

Embodiment 2

[0022] Add 13.5g (0.1mol) ethyl 2-chloropropionate, 135g carbon tetrachloride, 12.8g (0.06mol) bromine, 13.5g (0.1mol) sulfuryl chloride, 0.3g Azoisobutyronitrile was stirred and heated to 60°C for reaction. After 10 h, the conversion rate of ethyl 2-chloropropionate was 85.6%, and the selectivity of ethyl 2-chloro-2-bromopropionate was 92.5%.

Embodiment 3

[0024] Add 16.7g (0.1mol) methyl 2-bromopropionate, 85g 1,1-difluorotetrachloroethane, 12.8g (0.08mol) bromine, 10.8g (0.08mol) Sulfuryl chloride and 0.2 g of benzoyl peroxide were stirred and heated to 80°C for reaction. After 8 hours, the conversion rate of methyl 2-bromopropionate was 82.4%, and the selectivity of methyl 2,2-dibromopropionate was 91.8%.

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PUM

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Abstract

The present invention discloses a synthesis method of a bromine-containing ester having a general formula of CH3CXBrCOOR. The synthesis method comprises: firstly taking a four-necked flask having a condensation pipe, sequentially adding an ester having a general formula of CH3CHXCOOR, an initiator, a catalyst, a solvent and bromine to the four-necked flask to form reactant, wherein X in the general formula represents a halogen, the halogen comprises fluorine, chlorine and bromine, and R represents alkyl; and stirring the reactant, carrying out a heating treatment on the reactant, heating to a reaction temperature, and carrying out a reaction for 6-10 h to obtain the bromine-containing ester having the general formula of CH3CXBrCOOR. According to the present invention, based on the defects in the prior art, the inexpensive bromide is adopted as the brominating reagent of CH3CHXCOOR, and the bromine-containing ester having the general formula of CH3CXBrCOOR is obtained under the effect of the initiator, the catalyst and the solvent under; and the method has advantages of mild condition and low reaction cost.

Description

technical field [0001] The present invention relates to a kind of synthetic method of bromine-containing ester, especially a kind of general formula is CH 3 The synthesis method of the bromine-containing ester of CXBrCOOR. Background technique [0002] An atom (atom on a non-functional group) or group (functional group) in an organic compound is replaced by a -Br to become a bromide, where the general formula is CH 3 The brominated ester of CXBrCOOR is a kind of brominated compound. The bromine-containing ester can remove a molecule of hydrogen halide under appropriate conditions to generate 2-haloacrylate. 2-halogenated acrylate can be used as a polymer monomer in plastic optical fiber, such as plastic optical fiber made of polymer with 2-fluoromethyl acrylate as monomer, its maximum service temperature is higher than that of conventional plastic optical fiber, suitable for In a working environment with high temperature. [0003] Chinese patent CN102428067A discloses a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C67/307C07C69/63
CPCC07C67/307C07C69/63
Inventor 叶立峰王树华
Owner JUHUA GROUP TECH CENT