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A controllable preparation method of polysaccharide derivative-induced gold nanoparticles

A polysaccharide derivative, gold nanoparticle technology, applied in nanotechnology, nanotechnology, nanotechnology and other directions for materials and surface science, achieving good application prospects, good water solubility and biocompatibility, and simple and easy operation steps row effect

Active Publication Date: 2017-06-27
东台海滨科技创业园管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] After searching, there is no report on the controllable preparation method of gold nanoparticles induced by codran polysaccharide derivatives

Method used

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  • A controllable preparation method of polysaccharide derivative-induced gold nanoparticles
  • A controllable preparation method of polysaccharide derivative-induced gold nanoparticles
  • A controllable preparation method of polysaccharide derivative-induced gold nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Preparation of oxidized Ketran polysaccharide derivatives

[0024] In 0.2 mol / L sodium acetate buffer solution (pH 4.8), add curdlan polysaccharide, sodium chlorate and 4-acetamide-2,2,6,6-tetramethylpiperidinyloxy free radical, place at 35 ℃ constant temperature water bath, mix well, quickly add sodium hypochlorite, seal the reaction for 48 hours, the excess mass concentration is 95% ethanol precipitation, stand overnight at 4 ℃, centrifuge at 5000 rpm for 20 minutes, dialyze with distilled water for 48 hours, freeze-dry to obtain oxidized Delan polysaccharide derivatives; described codlan polysaccharide is a white solid powder, purchased from Japan Wako Pure Chemical Co., Ltd.; described sodium acetate buffer solution, codlan polysaccharide, sodium chlorate, 4-acetamide-2 , 2,6,6-tetramethylpiperidinyloxy radical, sodium hypochlorite mass volume ratio is 100 (mL): 1 (g): 0.68 (g): 0.096 (g): 0.62 (mL), the oxidation The number-average molecular weight o...

Embodiment 2

[0026] Add 2.0 mL of oxidized codran polysaccharide solution with a mass concentration of 2.0 mg / mL and a pH of 5.5 to 2.0 mL of a chloroauric acid aqueous solution with a molar concentration of 10 mmol / L, mix well, seal, and react at a constant temperature of 100 °C After 1.5 h, cool to room temperature, filter, centrifuge, disperse, dialyze and freeze-dry to obtain polysaccharide fund nanoparticles.

[0027] Disperse the gold nanoparticles prepared above in deionized water to obtain an aqueous solution of gold nanoparticles with a mass concentration of 0.5 mg / mL, and observe its TEM image, as shown in figure 1 As shown, the morphology of gold nanoparticles is mostly rod-shaped, triangular and spherical, and the particle size uniformity is poor, accompanied by a small amount of agglomeration.

Embodiment 3

[0029] This example is basically the same as Example 2, except that a sodium hydroxide solution with a molar concentration of 1.0 mol / L is used to adjust the pH of the oxidized curdlan polysaccharide solution to 7.9.

[0030] Observe the TEM figure of the above-mentioned prepared gold nanoparticles, such as figure 2 As shown, the morphology of gold nanoparticles is spherical and rod-shaped, the average diameter of spherical nanoparticles is ~26 nm, and the average length of rod-shaped nanoparticles is ~32 nm.

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Abstract

The invention discloses a controllable preparation method for gold nanoparticles induced by a polysaccharide derivative, and belongs to the technical field of green preparation of nano materials. The controllable preparation method includes the steps that under the acidity condition (pH4.8), an oxidized curdlan polysaccharide derivative is prepared through 4-accetamide-2, 2, 6, 6-tetramethyl piperidine-1-oxyl, sodium chlorate and sodium hypochlorite; the pH of the oxidized curdlan polysaccharide solution is adjusted, the solution is mixed with a chloroauric acid solution at the same volume, reaction is performed for 1.5 h at the temperature of 100 DEG C, a mixed solution is cooled to a room temperature, then filtered, centrifuged, dispersed, dialyzed, frozen and dried to obtain the gold nanoparticles, and through control over the pH value of the oxidized curdlan polysaccharide solution, gold nanoparticles of different shapes and grain sizes can be obtained. In this way, the preparation method is environmentally friendly, simple, easy to implement and good in stability, the shape and grain size of the gold nanoparticles are controllable, continuous large-scale production can be achieved, and the method has good application prospects.

Description

technical field [0001] The invention relates to the technical field of green preparation of nanometer materials, in particular to a method for the controllable preparation of gold nanoparticles by using codran polysaccharide derivatives as reducing agents and stabilizing agents. Background technique [0002] In recent years, nano-sized functional nanoparticles and polymer assemblies have remarkable efficacy in the construction of nanomaterials, and have attracted widespread attention. Among them, gold nanoparticles have good applications in the fields of catalysis, nanoprobes, surface Raman enhancement, biomedicine and food safety detection due to their nanometer size and excellent physical and chemical properties, making them widely used in many nanoparticle Much favored in. In particular, the synthesis of nanomaterials using the special structures and properties of polysaccharides and their derivatives has become an emerging research topic in the field of nanomaterial pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y30/00B82Y40/00
Inventor 闫景坤马海乐任晓锋王振斌裴娟娟
Owner 东台海滨科技创业园管理有限公司
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